Results 81 to 90 of about 918,156 (339)

Biocidal Agents Used for Disinfection Can Enhance Antibiotic Resistance in Gram-Negative Species

Antibiotics, 2018
Biocidal agents used for disinfection are usually not suspected to enhance cross-resistance to antibiotics. The aim of this review was therefore to evaluate the effect of 13 biocidal agents at sublethal concentrations on antibiotic resistance in Gram ...
Günter Kampf
doaj   +1 more source

Nucleoside Reverse Transcriptase Inhibitor Resistance Mutations Associated with First-Line Stavudine-Containing Antiretroviral Therapy: Programmatic Implications for Countries Phasing Out Stavudine [PDF]

, 2017
Background The World Health Organization Antiretroviral Treatment Guidelines recommend phasing-out stavudine because of its risk of long-term toxicity. There are two mutational pathways of stavudine resistance with different implications for zidovudine ...
Aghokeng, Avelin, Belec, Laurent, Bertagnolio, Silvia, Bunupuradah, Torsak, Burda, Sherri, Cane, Patricia, Cappelli, Giulia, Charpentier, Charlotte, Dagnra, Anoumou Y., de Wit, Tobias F. Rinke, Deshpande, Alaka K., El-Katib, Ziad, Eshleman, Susan H., Fleury, Herve J., Fokam, Joseph, Ford, Nathan, Gody, Jean-Chrysostome, Hamers, Raph L., Hawkins, Claudia A., Holmes, Susan, Hosseinipour, Mina C., Jordan, Michael R., Kanki, Phyllis J., Katzenstein, David, Koyalta, Donato D., Kumwenda, Johnstone J., Lallemant, Marc, Lynen, Lutgarde, Manosuthi, Weerawat, Marconi, Vincent C., Margot, Nicolas A., Moussa, Sandrine, Ndung'u, Thumbi, Ngo-Giang-Huong, Nicole, Nyambi, Phillipe N., Orrell, Catherine, Peeters, Martine, Rhee, Soo-Yon, Ruxrungtham, Kiat, Schapiro, Jonathan M., Schuurman, Rob, Shafer, Robert W., Sigaloff, Kim C., Sirivichayakul, Sunee, Smith, Davey, Stevens, Wendy, Tang, Michele W., van Zyl, Gert U., Wallis, Carole L., Zolfo, Maria   +49 more
core  

Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]

, 2009
The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The Actual Clinical Situation Ruthlessly Exposes the Challenge of Rational Care for Nosocomial and Community-Acquired Infections and Requires Even More Efforts for Satisfactory Antibiotic Stewardship

Antibiotics
Background: Antimicrobial resistance is one of the 10 most pressing health problems worldwide. Methods: First steps toward harnessing the complex dynamics of antibiotic resistance are presented.
Hans H. Diebner, A. Melina Wallrafen, Nina Timmesfeld, Tim Rahmel, Hartmuth Nowak   +4 more
doaj   +1 more source

Resistance of Amaranthus retroflexus to acetolactate synthase inhibitor herbicides in Brazil [PDF]

Planta Daninha, 2014
When in competition with cotton, Amaranthus retroflexus can cause high yield losses. Due to the limited availability of selective herbicides registered for post emergence control of this weed, the same herbicides have been used repeated times over the ...
A.C. Francischini, J. Constantin, R.S. Oliveira Jr., G. Santos, L.H.M. Franchini, D.F. Biffe   +5 more
doaj   +1 more source

Engineered transfer of the PKS/NRPS biosynthesis pathway of albicidin: A promising approach to overproduce this potent antibiotic [PDF]

, 2006
Xanthomonas albilineans, which causes leaf scald disease of sugarcane, produces a highly potent pathotoxin and antibiotic called albicidin that was shown to inhibit DNA replication in both sugarcane proplastids and Escherichia coli.
Cociancich, Stéphane, Duplan, Sandrine, Gabriel, Dean W., Pieretti, Isabelle, Pitorre, Delphine, Rott, Philippe, Royer, Monique, Vivien, Eric   +7 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Cross-resistance to Bacillus sphaericus strains in Culex quinquefasciatus. [PDF]

, 1996
Volume ...

core  

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors [PDF]

, 2005
RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture.
Fisher, Timothy S, Joshi, Pheroze, Prasad, Vinayaka R   +2 more
core   +3 more sources