Results 81 to 90 of about 2,737,931 (291)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Prevalência da maloclusão e necessidade de tratamento ortodôntico em escolares de 10 a 14 anos de idade em Belo Horizonte, Minas Gerais, Brasil: enfoque psicossocial

Cadernos de Saúde Pública
Os objetivos deste estudo transversal foram determinar a prevalência da maloclusão e verificar a associação entre necessidade normativa de tratamento ortodôntico e determinados aspectos psicossociais.
Leandro Silva Marques, Cristiane Carvalho Barbosa, Maria Letícia Ramos-Jorge, Isabela Almeida Pordeus, Saul Martins Paiva   +4 more
doaj  

Knowledge of mpox and its determinants among the healthcare personnel in Arabic regions: A multi-country cross-sectional study

, 2023
Sarya Swed, Haidara Bohsas, Muhammad Mainuddin Patwary, Ismail Ibrahim, Amine Rakab, Abdulqadir J. Nashwan, Wael Hafez, Noheir Ashraf Ibrahem Fathy Hassan, Sheikh Shoib, Mohamed Elsayed, Bisher Sawaf, Mhd Kutaiba Albuni, Elias Battikh, Gihan mustafa kamal Mohamed, Adel Albozom, Ebrahim Shaddad, Sherihan Fathey, Mila Nu Nu Htay, Sanjit Sah, Iván Chérrez-Ojeda, Aroop Mohanty, Bijaya Kumar Padhi, Alfonso J. Rodríguez‐Morales, Aravind P. Gandhi, Ranjit Sah   +24 more
openalex   +1 more source

Differential mortality and wealth accumulation [PDF]

An issue central to the life-cycle theory of consumer behavior, and to many policy questions, is asset accumulation and decumulation. One of the main implications of the life-cycle model is that assets are decumulated in the last part of life.
H. W. Hoynes, O. Attanasio
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Epidemiological profile of patients treated at the Cornea's Department of the Reference Center in Ophthalmology, Goiás, Brazil [PDF]

Revista Brasileira de Oftalmologia
Objective: To describe the epidemiological profile of corneal disorders diagnosed in the Corneal Department of the Ophthalmology Reference Center, Universidade Federal de Goiás, between 2009 and 2018.
Fernanda Mendonça Galvão, Alexia Larissa de Souza, Hugo Mendes Silva, Marcia Cristina Toledo, Victor Falcão Pereira Costa, Yael Porto Silva, Cláudia Gomide Vilela de Sousa Franco, Larissa Fernanda Queiroz Elias, Marcos Rassi Fernandes   +8 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their Bioavailable Fractions in Community-dwelling Men [PDF]

, 1998
Rebecca Ferrini, Elizabeth Barrett‐Connor   +1 more
openalex   +1 more source

Prevalence and Associated Factors of Low Back Pain Among Healthcare Professionals at University of Gondar Comprehensive and Specialized Hospital, Northwest Ethiopia: Cross-Sectional Study

, 2022
Nini Asfaw Negash, Azmeraw Tadele, Abebaw Jember Ferede   +2 more
openalex   +2 more sources

Osteoarthritis, entheses, and long bone cross-sectional geometry in the Andes: Usage, history, and future directions. [PDF]

, 2019
Akin to approaches encouraged by Verano (1997) in the Andes, and Ortner (2011, 2012) for general paleopathological studies, this article focuses on accurate descriptions and definitions of osteoarthritis, entheses, and long bone cross-sectional geometry.
Becker, Sara K
core   +1 more source