Results 101 to 110 of about 8,137,182 (304)

Approximate leave-future-out cross-validation for Bayesian time series models [PDF]

open access: yes, 2019
One of the common goals of time series analysis is to use the observed series to inform predictions for future observations. In the absence of any actual new data to predict, cross-validation can be used to estimate a model's future predictive accuracy ...
Paul-Christian Burkner   +2 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Upper extremity function in hemiplegia. A cross-validation study of two assessment methods.

open access: yesScandinavian Journal of Rehabilitation Medicine, 2020
The methods devised by DeSouza et al. and by Fugl-Meyer et al. for description of upper extremity function after stroke were compared by parallel assessments in a consecutive series of 50 patients with hemimotor deficit.
K. Berglund, Fugl-Meyer Ar
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

An Approximate Regularized ML Approach to Censor Outliers in Gaussian Radar Data

open access: yesIEEE Access, 2019
This paper considers the problem of censoring outliers from the secondary dataset in a radar scenario where the sample support is limited. To this end, the generalized regularized likelihood function (GRLF) criterion is used and the corresponding ...
Sudan Han   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Métodos de ajuste e modelos de semivariograma aplicados ao estudo da variabilidade espacial de atributos físico-hídricos do solo Fitting methods and semi-variogram models applied to the study of spatial variability of physical-hydric soil attributes

open access: yesRevista Brasileira de Ciência do Solo, 2007
Avaliou-se a variabilidade e a estrutura de dependência espacial de atributos físico-hídricos do solo (volume total de poros - VTP, condutividade hidráulica saturada - k0, porosidade drenável - PD e conteúdo de água volumétrico na capacidade de campo ...
Natalino Martins Gomes   +4 more
doaj   +1 more source

Visual Speech Recognition Using PCA Networks and LSTMs in a Tandem GMM-HMM System

open access: yes, 2017
Automatic visual speech recognition is an interesting problem in pattern recognition especially when audio data is noisy or not readily available.
Ekenel, Hazım Kemal   +3 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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