Results 141 to 150 of about 5,480 (194)
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Alkenol−Alkyne Cross Metathesis
Organic Letters, 2008Allyl alcohols and their homologues were used in the enyne cross metathesis to prepare hydroxy-functionalized dienes. An isomerization was found to occur under prolonged heating, and a method for conversion to ( E)-diene product is also reported.
Daniel A, Clark +2 more
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Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis
Bioconjugate Chemistry, 2017DNA-encoded library technology (ELT) is now widely used in pharmaceutical, biotechnological, and academic research for hit identification and target validation. New on-DNA reactions are keys to exploring greater chemical space and accessing challenging chemotypes such as configurationally constrained macrocycles.
Xiaojie Lu +4 more
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Advanced Synthesis & Catalysis, 2007
AbstractThe application of olefin cross‐metathesis to vinyl‐functionalized thiazoles and the tandem Stille coupling/cross‐metathesis of bis‐trifloylthiazoles are reported. These processes offer new opportunities for the synthesis of complex natural products.
Jyotirmayee Dash +2 more
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AbstractThe application of olefin cross‐metathesis to vinyl‐functionalized thiazoles and the tandem Stille coupling/cross‐metathesis of bis‐trifloylthiazoles are reported. These processes offer new opportunities for the synthesis of complex natural products.
Jyotirmayee Dash +2 more
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2007
Olefin cross-metathesis has become an indispensable tool for efficient carbon–carbon bond formation. Fundamental studies on functional group tolerance and an understanding of the steric and electronic factors crucial to product selectivity have led to the development of an empirical model for reaction design.
Grubbs, R. H. +2 more
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Olefin cross-metathesis has become an indispensable tool for efficient carbon–carbon bond formation. Fundamental studies on functional group tolerance and an understanding of the steric and electronic factors crucial to product selectivity have led to the development of an empirical model for reaction design.
Grubbs, R. H. +2 more
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Olefin cross-metathesis with vinyl halides
Chemical Communications, 2008The first successful example of olefin cross-metathesis with chloroalkenes is reported.
Volodymyr, Sashuk +3 more
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2018
Abstract During the past two decades, among all the types of transition-metal-catalyzed reaction, olefin metathesis has become arguably the most powerful synthetic tool for carbon–carbon bond formation. The reason for this is undoubtedly the development of well-defined functional-group-tolerant N-heterocyclic carbene (NHC) based ruthenium alkylidene ...
A. Jana, P. Malecki, K. Grela
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Abstract During the past two decades, among all the types of transition-metal-catalyzed reaction, olefin metathesis has become arguably the most powerful synthetic tool for carbon–carbon bond formation. The reason for this is undoubtedly the development of well-defined functional-group-tolerant N-heterocyclic carbene (NHC) based ruthenium alkylidene ...
A. Jana, P. Malecki, K. Grela
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Chemical & Engineering News Archive, 2007
OLEFIN CROSS-METATHESIS , the coupling of two distinct alkenes, is a useful synthetic organic reaction, but it has only rarely been achieved on solid phase. Researchers have now found that proper spacing between the polymer support and the tethered alkene makes the solid-phase reaction more feasible.
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OLEFIN CROSS-METATHESIS , the coupling of two distinct alkenes, is a useful synthetic organic reaction, but it has only rarely been achieved on solid phase. Researchers have now found that proper spacing between the polymer support and the tethered alkene makes the solid-phase reaction more feasible.
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Tandem dienyne cross-metathesis/ring-closing metathesis
Tetrahedron Letters, 2001Abstract Tandem enyne cross-metathesis/ring-closing metathesis between terminal alkynes and 1,5-hexadiene has been demonstrated using the 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium benzylidene complex. Synthesis of 2-substituted 1,3-cyclohexadienes using this one step tandem reaction is reported.
Jason A Smulik, Steven T Diver
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Catalytic Nitrile-Alkyne Cross-Metathesis
Journal of the American Chemical Society, 2007The first catalytic cross-metathesis reaction of an alkyne with a nitrile is described. The nitride complex N⋮W(OC(CF3)2CH3)3(DME) undergoes reversible triple-bond metathesis reactions with alkynes (RC⋮CR; R = Et, 4-C6H4OMe), forming the alkylidyne complexes RC⋮W(OC(CF3)2CH3)3(DME) (R = Et, 4-C6H4OMe) along with the corresponding nitrile RC⋮N. This has
Andrea M, Geyer +3 more
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Cross-Metathesis Assisted by Microwave Irradiation
The Journal of Organic Chemistry, 2005Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the phosphine-free Hoveyda-Grubbs catalyst and the "second generation Grubbs' catalyst." While there have been reports that a "microwave effect" is observed in various transformations, the accelerations we ...
Frédéric C, Bargiggia +1 more
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