Synthesis of Cystine-Stabilised Dicarba Conotoxin EpI: Ring-Closing Metathesis of Sidechain Deprotected, Sulfide-Rich Sequences [PDF]
Marine Drugs, 2023 Recombinant peptide synthesis allows for large-scale production of peptides with therapeutic potential. However, access to dicarba peptidomimetics via sidechain-deprotected sequences becomes challenging with exposed Lewis basicity presented by amine and ...
Amy L. Thomson +2 more
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Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins [PDF]
Molecules, 2020 Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by
Marc Liniger +2 more
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Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides
Molecules, 2010 Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.
Pål Rongved +2 more
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Design and synthesis of C3-symmetric molecules bearing propellane moieties via cyclotrimerization and a ring-closing metathesis sequence [PDF]
Beilstein Journal of Organic Chemistry, 2018 We have developed an efficient synthetic strategy to assemble C3-symmetric molecules containing propellane moieties as end groups and a benzene ring as a central core. The synthesis of these C3-symmetric molecules involves simple starting materials.
Sambasivarao Kotha +2 more
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Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis [PDF]
Molecules, 2019 Three types of pyrazole-fused heterobicycles, i.e., 1,5-, 1,7-, and 2,5-dihydropyrano[3,2-c]pyrazoles, were synthesized from 4-allyloxy-1H-pyrazoles. A sequence of the Claisen rearrangement of 4-allyloxy-1H-pyrazoles, ruthenium-hydride-catalyzed double ...
Yoshihide Usami +5 more
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Silicon Catalyzed C−O Bond Ring Closing Metathesis of Polyethers [PDF]
Angewandte Chemie - International Edition, 2022 Nils Ansmann +2 more
exaly +2 more sources
Bridgehead vicinal diallylation of norbornene derivatives and extension to propellane derivatives via ring-closing metathesis [PDF]
Beilstein Journal of Organic Chemistry, 2016 Here, we report a simple synthetic strategy to the bridgehead vicinal diallylation of norbornene derivatives. These substrates are useful to generate propellanes via ring-closing metathesis. Single-crystal X-ray diffraction analysis of four compounds led
Sambasivarao Kotha, Rama Gunta
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Stereodivergent approach in the protected glycal synthesis of L-vancosamine, L-saccharosamine, L-daunosamine and L-ristosamine involving a ring-closing metathesis step [PDF]
Beilstein Journal of Organic Chemistry, 2018 In this paper, a new access to several chiral 3-aminoglycals as potential precursors for glycosylated natural products is reported from a common starting material, (−)-methyl-L-lactate.
Pierre-Antoine Nocquet +8 more
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Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction
Chemistry Proceedings, 2023 Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
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Molecules, 2005 Sesqui- and sesterterpenes of ophiobolin and fusicoccin families are important synthetic targets because of complexity of structure and potentially useful physiological activities, including anti-tumor activity.
J. Wicha, M. Michalak, K. Michalak
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