Synthesis of Cystine-Stabilised Dicarba Conotoxin EpI: Ring-Closing Metathesis of Sidechain Deprotected, Sulfide-Rich Sequences [PDF]
Marine Drugs, 2023 Recombinant peptide synthesis allows for large-scale production of peptides with therapeutic potential. However, access to dicarba peptidomimetics via sidechain-deprotected sequences becomes challenging with exposed Lewis basicity presented by amine and ...
Amy L. Thomson +2 more
doaj +2 more sources
Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins [PDF]
Molecules, 2020 Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by
Marc Liniger +2 more
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Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides
Molecules, 2010 Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.
Pål Rongved +2 more
doaj +3 more sources
Design and synthesis of C3-symmetric molecules bearing propellane moieties via cyclotrimerization and a ring-closing metathesis sequence [PDF]
Beilstein Journal of Organic Chemistry, 2018 We have developed an efficient synthetic strategy to assemble C3-symmetric molecules containing propellane moieties as end groups and a benzene ring as a central core. The synthesis of these C3-symmetric molecules involves simple starting materials.
Sambasivarao Kotha +2 more
doaj +2 more sources
Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis [PDF]
Molecules, 2019 Three types of pyrazole-fused heterobicycles, i.e., 1,5-, 1,7-, and 2,5-dihydropyrano[3,2-c]pyrazoles, were synthesized from 4-allyloxy-1H-pyrazoles. A sequence of the Claisen rearrangement of 4-allyloxy-1H-pyrazoles, ruthenium-hydride-catalyzed double ...
Yoshihide Usami +5 more
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Silicon Catalyzed C−O Bond Ring Closing Metathesis of Polyethers [PDF]
Angewandte Chemie - International Edition, 2022 Nils Ansmann +2 more
exaly +2 more sources
Bridgehead vicinal diallylation of norbornene derivatives and extension to propellane derivatives via ring-closing metathesis [PDF]
Beilstein Journal of Organic Chemistry, 2016 Here, we report a simple synthetic strategy to the bridgehead vicinal diallylation of norbornene derivatives. These substrates are useful to generate propellanes via ring-closing metathesis. Single-crystal X-ray diffraction analysis of four compounds led
Sambasivarao Kotha, Rama Gunta
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Stereodivergent approach in the protected glycal synthesis of L-vancosamine, L-saccharosamine, L-daunosamine and L-ristosamine involving a ring-closing metathesis step [PDF]
Beilstein Journal of Organic Chemistry, 2018 In this paper, a new access to several chiral 3-aminoglycals as potential precursors for glycosylated natural products is reported from a common starting material, (−)-methyl-L-lactate.
Pierre-Antoine Nocquet +8 more
doaj +2 more sources
Supported Catalysts Useful in Ring-Closing Metathesis, Cross Metathesis, and Ring-Opening Metathesis Polymerization. [PDF]
Polymers (Basel), 2016 Ruthenium and molybdenum catalysts are widely used in synthesis of both small molecules and macromolecules. While major developments have led to new increasingly active catalysts that have high functional group compatibility and stereoselectivity, catalyst/product separation, catalyst recycling, and/or catalyst residue/product separation remain an ...
Suriboot J, Bazzi HS, Bergbreiter DE.
europepmc +4 more sources
Tandem Ring‐Opening–Ring‐Closing Metathesis for Functional Metathesis Catalysts [PDF]
Angewandte Chemie International Edition, 2016 AbstractUse of a tandem ring‐opening–ring‐closing metathesis (RORCM) strategy for the synthesis of functional metathesis catalysts is reported. Ring opening of 7‐substituted norbornenes and subsequent ring‐closing metathesis forming a thermodynamically stable 6‐membered ring lead to a very efficient synthesis of new catalysts from commercially ...
Amit A. Nagarkar +4 more
openaire +6 more sources