Results 91 to 100 of about 685,322 (306)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
A Revised Modular Approach to D8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions [PDF]
, 2019 In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-trans-Δ8-THC derivatives, which can be used to modulate the pharmacologically important CB1 and CB2 receptors.
Floris, P. J. T. Rutjes +5 more
core +1 more source
Beilstein Journal of Organic ChemistryIn this study, we develop the synthesis methods of fluoroalkenes and fluoroenynes via Suzuki–Miyaura and Sonogashira cross-coupling reactions using novel multihalogenated fluorovinyl ethers, which are easily prepared from the reaction between phenols and
Yukiko Karuo +5 more
doaj +1 more source
Recent Advances in Noble Metal Nanocatalysts for Suzuki and Heck Cross-Coupling Reactions
Molecules, 2010 Since metal nanoparticles have a high surface-to-volume ratio and very active surface atoms, they are very attractive catalysts for a wide variety of organic and inorganic reactions, compared to bulk catalysts.
Radha Narayanan
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Organophosphates as Versatile Substrates in Organic Synthesis
MoleculesThis review summarizes the applications of organophosphates in organic synthesis. After a brief introduction, it discusses cross-coupling reactions, including both transition-metal-catalyzed and transition-metal-free substitution reactions. Subsequently,
Petr Oeser, Tomáš Tobrman
doaj +1 more source
Journal of the Turkish Chemical Society, Section A: Chemistry, 2017 There are quite many examples in the scientific literature regarding the acylation reactions, especially the metal-catalyzed acylation reactions, metal-free acylation reactions, metal-catalyzed acylation via cross-dehydrogenative coupling (CDC) reactions
Soykan Ağar, Ömer Tahir Günkara
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions [PDF]
, 2020 Nickel-catalyzed reductive cross-coupling reactions have emerged as powerful methods to join two electrophiles. These reactions have proven particularly useful for the coupling of sec-alkyl electrophiles to form stereogenic centers; however, the ...
Reisman, Sarah E. +2 more
core
Perceived parental reactions to coming out, attachment, and romantic relationship views [PDF]
, 2011 Coming out as lesbian, gay, or bisexual (LGB) to one’s parents can be a challenging experience and may lead to acceptance or rejection. Attachment theory can help predict parents’ reactions to coming out and consequences for romantic attachment.
EG, Hepper +14 more
core +1 more source