Results 101 to 110 of about 685,322 (306)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species. [PDF]

Microorganisms, 2023
Kanegae H, de Souza Suguiura IM, Tashiro R, Konno T, Hou DX, Sano A, Eto T, Ueda K, Hossain MA.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides [PDF]

, 2007
Article number 18A convenient microwave accelerated cross-coupling procedure between aryl chlorides with a range of boronic acids has been developed. An explanation for the low reactivity of highly fluorinated boronic acids in Suzuki coupling is provided.
Matthew L. Clarke, Marcia B. France, Edward J. Milton, Jose A. Fuentes, Clarke, Matthew L., France, Marcia B., Milton, Edward J., Fuentes, José A., Roff, Geoffrey J., Geoffrey J. Roff   +9 more
core   +1 more source

Acetonyl Peroxy and Hydroperoxy Self- and Cross-Reactions: Temperature-Dependent Kinetic Parameters, Branching Fractions, and Chaperone Effects. [PDF]

J Phys Chem A, 2023
Zuraski K, Grieman FJ, Hui AO, Cowen J, Winiberg FAF, Percival CJ, Okumura M, Sander SP.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Metal Catalysed Cross-Coupling Reactions of Heterocycles [PDF]

This report describes two methodology studies dedicated towards development of metal catalysed crosscoupling reactions in the synthesis of novel heterocyclic compounds.
Adams, Kirsty
core  

A highly efficient ion-exchange resin supported Au-Pd alloy catalyst for Suzuki cross-coupling and Ullmann reactions in water [PDF]

, 2012
A highly efficient ion-exchange resin supported Au-Pd alloy catalyst for Suzuki cross-coupling and Ullmann reactions in ...
张涛, 张磊磊, 黄延强, 王爱琴
core  

Cross-Coupling Reactions of Alkenylsilanols with Fluoroalkylsulfonates [PDF]

, 2016
The design and development of an effective protocol for the palladium-catalyzed cross-coupling of (E)- and (Z)-heptenyldimethylsilanols with organo-triflates and nonaflates is described.
Scott E. Denmark (1310370), Ramzi F. Sweis (766111)   +1 more
core   +1 more source

Computational Investigation of Substituent Effects on the Alcohol + Carbonyl Channel of Peroxy Radical Self- and Cross-Reactions. [PDF]

J Phys Chem A, 2023
Hasan G, Salo VT, Golin Almeida T, Valiev RR, Kurtén T.   +4 more
europepmc   +1 more source