Results 121 to 130 of about 708,583 (355)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Mononuclear Palladium(I) Aryl Complexes Performs Cross-Coupling Reactions with Organic Halides

open access: yes
Mononuclear Pd(I) species represent the least understood Pd intermediates in Pd-catalyzed reactions and isolable complexes of the type are exceedingly rare. Herein, we report the synthesis and characterization of mononuclear Pd(I) complexes bear-ing aryl
Tianqi, Xia   +4 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Capture cross sections for heavy-ion reactions producing compound system with Z = 12 [PDF]

open access: yesЯдерна фізика та енергетика, 2012
The fusion cross sections for reactions 50Ti + 249Cf, 54Cr + 248Cm, 58Fe + 244Pu and 64Ni + 238U are evaluated in the framework of simple barrier-penetration model, which takes into account quadrupole and hexadecapole surface deformations of nuclei.
N. A. Pilipenko, V. Yu. Denisov
doaj  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Cross section of γ-rays irradiation in reactions of neutron absorption by iron [PDF]

open access: yesЯдерна фізика та енергетика, 2008
Differential cross sections of the reactions natFe(n, xγ) with neutron energy 14.1 MeV are unfolded from instrumental spectra using regularization procedure by Tikhonov and algorithm on the compact set of limited variations.
V. M. Bondar   +4 more
doaj  

3D Printed Tetrakis(triphenylphosphine)palladium (0) Impregnated Stirrer Devices for Suzuki-Miyaura Cross-Coupling Reactions

open access: green, 2020
Matthew T. Penny   +4 more
openalex   +1 more source

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