Results 71 to 80 of about 760,529 (249)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Survival Mediated Heavy Element Capture Cross Sections

EPJ Web of Conferences, 2017
Formally, the cross section for producing a heavy evaporation residue, σEVR, in a fusion reaction can be written as σEVR(E)=πh22μE∑ℓ=0∞(2ℓ+1)T(E,ℓ)PCN(E,ℓ)Wsur(E,ℓ),(1) where E is the center of mass energy, and T is the probability of the colliding ...
Loveland Walter, Yao Larry
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Relativistic cross sections of tidal disruption events

EPJ Web of Conferences, 2012
In this contribution I introduce and discuss the so-called cross sections of tidal disruption and partial mass stripping of stars after a tidal encounter with a rotating supermassive black hole. The presented approach is fully relativistic.
Ivanov P.B.
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Extension of the Discrete Electron Transport Capabilities of the Geant4-DNA Toolkit to MeV Energies

Applied Sciences
The discrete physics models available in the Geant4-DNA Monte Carlo toolkit are a subject of continuous evolution and improvement in order to meet the needs of state-of-the-art radiobiological research for medical and space applications.
Ioanna Kyriakou, Hoang N. Tran, Laurent Desorgher, Vladimir Ivantchenko, Susanna Guatelli, Giovanni Santin, Petteri Nieminen, Sebastien Incerti, Dimitris Emfietzoglou   +8 more
doaj   +1 more source

Electron Capture Cross Sections for Stellar Nucleosynthesis

Advances in High Energy Physics, 2015
In the first stage of this work, we perform detailed calculations for the cross sections of the electron capture on nuclei under laboratory conditions.
P. G. Giannaka, T. S. Kosmas
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source