Results 61 to 70 of about 6,572,452 (347)
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze+3 more
wiley +1 more source
Strategies for Selecting Crosses Using Genomic Prediction in Two Wheat Breeding Programs
The single most important decision in plant breeding programs is the selection of appropriate crosses. The ideal cross would provide superior predicted progeny performance and enough diversity to maintain genetic gain.
Bettina Lado+10 more
doaj +1 more source
The Misuse of Genetics: The Dihybrid Cross & the Threat of “Race Crossing” [PDF]
Biology teachers consider basic Mendelian genetics to be value-free, objective science, immune to misinterpretation and misuse. It may thus come as a surprise to learn that in the early days of genetics a cornerstone of genetics education, the dihybrid cross, was employed to support claims of the racial superiority of whites over blacks and to provide ...
openaire +2 more sources
Genetic Dissection of Cytonuclear Epistasis in Line Crosses [PDF]
Abstract Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL × cytoplasm interactions to the phenotypic ...
Zefeng Yang+4 more
openaire +3 more sources
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa+8 more
wiley +1 more source
The objective of the present study was to evaluate 44 soybean octuple crosses in the F4:3[8] and F5:3[8] generations in order to select progenies superior for seed oil yield (OY) and other important agronomic characteristics.
Hamawaki Osvaldo Toshiyuki+2 more
doaj
Heterosis studies for agronomic trait under different environmental conditions in sesame (Sesamum indicum L.) [PDF]
An investigation was carried out to study extent of heterosis under four different environments for yield and its component traits in sesame. Diallel mating design excluding reciprocals was used to develop 28 F1 crosses from eight parents.
Narendra Kumar, S. B. S. Tikka, Bhagirath Ram, M. C. Dagla
doaj
Restriction Fragment Length Polymorphism Linkage Map for Arabidopsis thaliana [PDF]
We have constructed a restriction fragment length polymorphism linkage map for the nuclear genome of the flowering plant Arabidopsis thaliana. The map, containing 90 randomly distributed molecular markers, is physically very dense; >50% of the genome is ...
Bowman, John L.+4 more
core +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source