Results 61 to 70 of about 364,075 (332)
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Strategies for Selecting Crosses Using Genomic Prediction in Two Wheat Breeding Programs
The Plant Genome, 2017 The single most important decision in plant breeding programs is the selection of appropriate crosses. The ideal cross would provide superior predicted progeny performance and enough diversity to maintain genetic gain.
Bettina Lado +10 more
doaj +1 more source
High-dimensional statistical inference for linkage disequilibrium score regression and its cross-ancestry extensions [PDF]
arXiv, 2023 Linkage disequilibrium score regression (LDSC) has emerged as an essential tool for genetic and genomic analyses of complex traits, utilizing high-dimensional data derived from genome-wide association studies (GWAS). LDSC computes the linkage disequilibrium (LD) scores using an external reference panel, and integrates the LD scores with only summary ...
arxiv
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Heterosis studies for agronomic trait under different environmental conditions in sesame (Sesamum indicum L.) [PDF]
Electronic Journal of Plant Breeding, 2015 An investigation was carried out to study extent of heterosis under four different environments for yield and its component traits in sesame. Diallel mating design excluding reciprocals was used to develop 28 F1 crosses from eight parents.
Narendra Kumar, S. B. S. Tikka, Bhagirath Ram, M. C. Dagla
doaj
Cryptic Genetic Variation Can Make Irreducible Complexity a Common Mode of Adaptation [PDF]
, 2013 The existence of complex (multiple-step) genetic adaptations that are "irreducible" (i.e., all partial combinations are less fit than the original genotype) is one of the longest standing problems in evolutionary biology. In standard genetics parlance, these adaptations require the crossing of a wide adaptive valley of deleterious intermediate stages ...
arxiv +1 more source
Bayesian methods for genetic association analysis with heterogeneous subgroups: From meta-analyses to gene-environment interactions [PDF]
Annals of Applied Statistics 2014, Vol. 8, No. 1, 176-203, 2011 Genetic association analyses often involve data from multiple potentially-heterogeneous subgroups. The expected amount of heterogeneity can vary from modest (e.g., a typical meta-analysis) to large (e.g., a strong gene--environment interaction). However, existing statistical tools are limited in their ability to address such heterogeneity. Indeed, most
arxiv +1 more source
Genetic Map of Bacteriophage [var phi]X174 [PDF]
, 1971 Bacteriophage [var phi]X174 temperature-sensitive and nonsense mutations in eight cistrons were mapped by using two-, three-, and four-factor genetic crosses.
Benbow, R. M. +3 more
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Genetics and Molecular Biology, 2000 The objective of the present study was to evaluate 44 soybean octuple crosses in the F4:3[8] and F5:3[8] generations in order to select progenies superior for seed oil yield (OY) and other important agronomic characteristics.
Hamawaki Osvaldo Toshiyuki +2 more
doaj