Antibacterial and Hemolytic Activity of Crotalus triseriatus and Crotalus ravus Venom [PDF]
Animals, 2020 Rattlesnakes have venoms with a complex toxin mixture comprised of polypeptides and proteins. Previous studies have shown that some of these polypeptides are of high value for the development of new medical treatments.
Adrian Zaragoza-Bastida +8 more
doaj +3 more sources
Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox [PDF]
Toxins, 2020 Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Harry F Williams +2 more
exaly +3 more sources
Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. [PDF]
PLoS Neglected Tropical DiseasesBackgroundPhenotypic polymorphism in rattlesnake venoms is well-documented, with a dichotomy between hemorrhagic (Type I) and neurotoxic (Type II) venoms.
Mônica Colombini +15 more
doaj +2 more sources
Crotoxin B from the South American Rattlesnake Crotalus vegrandis Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity [PDF]
ToxinsNeurotoxicity following South American Crotalus rattlesnake bite is primarily caused by crotoxin, the most abundant component in their venom. Despite the central role of voltage-gated calcium channels (CaV) in neurotransmission, direct targetability by ...
Markus Eicheldinger +5 more
doaj +2 more sources
Rapid, label-free surface plasmon resonance discrimination between Bothrops and Crotalus venoms using clinical antivenom as the capture reagent. [PDF]
PLoS Neglected Tropical DiseasesSnake envenoming is recognized as a global health problem, affecting thousands of people every year. One of the main challenges in addressing this issue is the correct identification and treatment of these envenomations, particularly in locations where ...
Ely S F Borges +5 more
doaj +2 more sources
Frontiers in Immunology, 2021 Crotalus durissus ruruima is a rattlesnake subspecies mainly found in Roraima, the northernmost state of Brazil. Envenomings caused by this subspecies lead to severe clinical manifestations (e.g.
Manuela B Pucca +2 more
exaly +3 more sources
Local and systemic effects caused by Crotalus durissus terrificus, Crotalus durissus collilineatus, and Crotalus durissus cascavella snake venoms in swiss mice [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2019 INTRODUCTION: Crotalus envenomations cause serious complications and can be fatal without appropriate treatment. Venom isoforms present and inter/intraspecific variations in the venom composition can result in different symptoms presented by bites by ...
Letícia Helena de Carvalho +13 more
doaj +6 more sources
Bioprospection of rattlesnake venom peptide fractions with anti-adipose and anti-insulin resistance activity in vitro [PDF]
Toxicon: XAnimal venoms are natural products that have served as a source of novel molecules that have inspired novel drugs for several diseases, including for metabolic diseases such as type-2 diabetes and obesity. From venoms, toxins such as exendin-4 (Heloderma
David Meléndez-Martínez +12 more
doaj +2 more sources
Caracterización clínica del paciente pediátrico atendido por mordedura de serpiente, Hospital Escuela, Tegucigalpa, 2015-2019 [PDF]
Revista Médica Hondureña, 2021 Antecedentes: Las manifestaciones clínicas de las mordeduras de serpientes son similares en adultos y niños, aunque más graves en estos últimos debido a la proporción de veneno inoculado por la serpiente y el tamaño corporal del paciente pediátrico ...
Scheybi Teresa Miralda Méndez
doaj +1 more source
A novel activity on thymocytes cells exerted by the rattlesnake (Crotalus durissus cumanensis) venom
Biomédica: revista del Instituto Nacional de Salud, 2021 Introduction: The thymus is active mainly during the neonatal and pre-adolescent periods. Objective: To test naïve thymocytes proliferation and monocytes stimulation. Materials and methods: We collected fresh thymus tissue from neonate mice after surgery.
María M. Pulido-Méndez +2 more
doaj +1 more source