Crotoxin Modulates Macrophage Phenotypic Reprogramming [PDF]
Toxins, 2023 Macrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenotype in response to the pathogen or the microenvironment. Several studies have shown that Crotoxin (CTX), the major
Camila Lima Neves +4 more
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Antibacterial Properties of Crotoxin from Crotalus durissus terrificus—Insight into the Mechanism of Action [PDF]
Molecules, 2022 The growing problem of antibiotic resistance among bacteria requires searching for new therapeutic agents with bacteriostatic and/or bactericidal properties. Crotoxin is a β-neurotoxin from the venom of the Crotalus durissus terrificus. It is composed of
Dorota Nemecz, Patrycja Golińska
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Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms [PDF]
Toxins, 2022 Crotoxin complex CA/CB and crotamine are the main toxins associated with Crotalus envenomation besides the enzymatic activities of phospholipases (PLA2) and proteases.
Miguel Angel Mejía-Sánchez +5 more
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Crotoxin Upregulating NLRP-3 Inflammasome and IL-18 and Activating CD4+ and CD8+ Lymphocytes in Experimental Encephalitozoon cuniculi Infection [PDF]
AnimalsEncephalitozoon cuniculi is an atypical, opportunistic, obligate intracellular fungal pathogen that infects vertebrates. It survives within the host by modulating the host immune response.
João Lourival de Souza +7 more
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Cytotoxic effects of crotoxin from Crotalus durissus terrificus snake in canine mammary tumor cell lines [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Mammary gland tumors are the most prevalent neoplasm in intact female dogs, and they are good natural models to study comparative oncology. Most canine mammary malignancies, as in women, are commonly refractory to conventional therapies and ...
Giovana Pedro +6 more
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Formyl Peptide Receptors 1 and 2: Essential for Immunomodulation of Crotoxin in Human Macrophages, Unrelated to Cellular Entry [PDF]
CellsCrotoxin (CTX), the main toxin in Crotalus durissus terrificus venom, is a heterodimeric complex known for its antitumoral, anti-inflammatory, and immunomodulatory properties.
Luciana de Araújo Pimenta +6 more
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Crotoxin B from the South American Rattlesnake Crotalus vegrandis Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity [PDF]
ToxinsNeurotoxicity following South American Crotalus rattlesnake bite is primarily caused by crotoxin, the most abundant component in their venom. Despite the central role of voltage-gated calcium channels (CaV) in neurotransmission, direct targetability by ...
Markus Eicheldinger +5 more
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Snake Venom PLA2 as Anticoagulant Agents: Role of Crotoxin, from Crotalus durissus Rattlesnake, in Hemostasis [PDF]
ToxinsSnake venoms are rich sources of bioactive molecules that modulate hemostasis and, among these, anticoagulant snake venom phospholipases A2 (sPLA2) are found in a range of snake venoms.
Lisele Maria Brasileiro-Martins +11 more
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Crotoxin induces cytotoxic effects in human malignant melanoma cells in both native and detoxified forms [PDF]
Frontiers in PharmacologyIntroduction: Melanoma, a highly aggressive skin cancer originating in melanocytes, poses a significant threat due to its metastatic potential. While progress has been made in treating melanoma with targeted therapies and immunotherapies, challenges ...
Tamires Cunha Almeida +8 more
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Immunorecognition and Neutralization of Crotalus durissus cumanensis Venom by a Commercial Antivenom Produced in Colombia [PDF]
Toxins, 2022 In Colombia, on average 2.9% of the nearly 5600 snakebite events that occur annually involve the rattlesnake Crotalus durissus cumanensis. The envenomation by this snake is mainly characterized by neurotoxicity and the main toxin is crotoxin (~64.7% of ...
Augusto Acosta-Peña +3 more
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