Results 21 to 30 of about 1,216 (181)

Crotoxin, the major toxin from the rattlesnake Crotalus durissus terrificus, inhibits ³H-choline uptake in guinea pig ileum

Brazilian Journal of Medical and Biological Research, 2000
We examined the effect of crotoxin, the neurotoxic complex from the venom of the South American rattlesnake Crotalus durissus terrificus, on the uptake of ³H-choline in minces of smooth muscle myenteric plexus from guinea pig ileum.
L.S. Kattah, M.M. Santoro, C.R. Diniz, M.E. De Lima   +3 more
doaj   +2 more sources

Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. [PDF]

PLoS Neglected Tropical Diseases
BackgroundPhenotypic polymorphism in rattlesnake venoms is well-documented, with a dichotomy between hemorrhagic (Type I) and neurotoxic (Type II) venoms.
Mônica Colombini, Anderson M Rocha, Luciana A Freitas-de-Sousa, Alison F A Chaves, Solange M T Serrano, Vinicius C Souza, Vincent L Viala, Inácio L M Junqueira-Azevedo, Felipe A Cerni, Marco A Sartim, Jacqueline A G Sachett, Wuelton M Monteiro, Felipe G Grazziotin, Fan Hui Wen, Manuela B Pucca, Ana M Moura-da-Silva   +15 more
doaj   +2 more sources

Intraspecific Differences in the Venom of Crotalus durissus cumanensis from Colombia [PDF]

Toxins, 2022
Biochemical and biological differences in the venom of Crotalus durissus cumanensis from three ecoregions of Colombia were evaluated. Rattlesnakes were collected from the geographic areas of Magdalena Medio (MM), Caribe (CA) and Orinoquía (OR). All three
Ariadna Rodríguez-Vargas, Nohora Vega, Edgar Reyes-Montaño, Gerardo Corzo, Edgar Neri-Castro, Herlinda Clement, Francisco Ruiz-Gómez   +6 more
doaj   +2 more sources

3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line [PDF]

Molecules
Breast cancer stands as the most prevalent type of tumor and a significant contributor to cancer-related deaths. Among its various subtypes, triple-negative breast cancer (TNBC) presents the worst prognosis due to its aggressive nature and the absence of
Patricia Bezerra, Eduardo F. Motti
doaj   +2 more sources

Effects of the Heterodimeric Neurotoxic Phospholipase A₂ from the Venom of Vipera nikolskii on the Contractility of Rat Papillary Muscles and Thoracic Aortas [PDF]

Toxins
Phospholipases A2 (PLA2s) are a large family of snake toxins manifesting diverse biological effects, which are not always related to phospholipolytic activity.
Alexey Averin, Vladislav Starkov, Victor Tsetlin, Yuri Utkin   +3 more
doaj   +2 more sources

Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors

Journal of Immunology Research, 2018
The Crotalus durissus terrificus rattlesnake venom, its main toxin, crotoxin (CTX), and its crotapotin (CA) and phospholipase A2 (CB) subunits modulate the immune system.
A. P. Freitas, B. C. Favoretto, P. B. Clissa, S. C. Sampaio, E. L. Faquim-Mauro   +4 more
doaj   +2 more sources

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

Mediators of Inflammation, 2016
We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte, Odair Jorge Faiad, Roberta Cornélio Ferreira Nocelli, Richardt G. Landgraf, Mario Sergio Palma, Yara Cury, Rui Curi, Sandra Coccuzzo Sampaio   +7 more
doaj   +2 more sources

The Proteome of African Spitting and Non-Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells. [PDF]

J Appl Toxicol
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Offor BC, Muller B, Motadi LR, Piater LA.   +3 more
europepmc   +2 more sources

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Complex regional pain syndrome following southern Pacific rattlesnake (C. oreganus helleri) envenoming

Clinical Case Reports, Volume 9, Issue 11, November 2021., 2021
Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but might be more common than previously reported. We present the third case of CRPS reported in North America and the first resulting from a pit‐viper's bite. Abstract Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but
Lawrence McLean House, Matthew R Lewin, Ramana K. Naidu, Halil Beqaj   +3 more
wiley   +1 more source