Results 21 to 30 of about 686 (159)

Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors

Journal of Immunology Research, 2018
The Crotalus durissus terrificus rattlesnake venom, its main toxin, crotoxin (CTX), and its crotapotin (CA) and phospholipase A2 (CB) subunits modulate the immune system.
A. P. Freitas, B. C. Favoretto, P. B. Clissa, S. C. Sampaio, E. L. Faquim-Mauro   +4 more
doaj   +2 more sources

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

Mediators of Inflammation, 2016
We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte, Odair Jorge Faiad, Roberta Cornélio Ferreira Nocelli, Richardt G. Landgraf, Mario Sergio Palma, Yara Cury, Rui Curi, Sandra Coccuzzo Sampaio   +7 more
doaj   +2 more sources

The Proteome of African Spitting and Non-Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells. [PDF]

J Appl Toxicol
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Offor BC, Muller B, Motadi LR, Piater LA.   +3 more
europepmc   +2 more sources

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Complex regional pain syndrome following southern Pacific rattlesnake (C. oreganus helleri) envenoming

Clinical Case Reports, Volume 9, Issue 11, November 2021., 2021
Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but might be more common than previously reported. We present the third case of CRPS reported in North America and the first resulting from a pit‐viper's bite. Abstract Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but
Lawrence McLean House, Matthew R Lewin, Ramana K. Naidu, Halil Beqaj   +3 more
wiley   +1 more source

Crotoxin Inhibits Endothelial Cell Functions in Two- and Three-dimensional Tumor Microenvironment

Frontiers in Pharmacology, 2021
Antitumor property of Crotoxin (CTX), the major toxin from Crotalus durissus terrificus snake venom, has been demonstrated in experimental animal models and clinical trials.
Ellen Emi Kato, Luciana Araújo Pimenta, Maíra Estanislau Soares de Almeida, Vanessa Olzon Zambelli, Marinilce Fagundes dos Santos, Sandra Coccuzzo Sampaio, Sandra Coccuzzo Sampaio   +6 more
doaj   +1 more source

Crotalic accidents in Brazil: actualities and perspectives

Revista Médica de Minas Gerais, 2022
Introduction: Ophidian accidents are neglected events in tropical and in developing countries, including Brazil. Serpents of the Crotalus genus (rattlesnakes) are those that produce the highest case-fatality in the country.
Hammer, Fernanda Martins, Feio, Renato Neves, Siqueira-Batista, Rodrigo   +2 more
doaj   +1 more source

Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model

Toxins, 2020
The most abundant protein families in viper venoms are Snake Venom Metalloproteases (SVMPs), Snake Venom Serine Proteases (SVSPs) and Phospholipases (PLA2s).
Edgar Neri-Castro, Melisa Bénard-Valle, Dayanira Paniagua, Leslie V. Boyer, Lourival D. Possani, Fernando López-Casillas, Alejandro Olvera, Camilo Romero, Fernando Zamudio, Alejandro Alagón   +9 more
doaj   +1 more source

Inhibition of L-glutamate and GABA synaptosome uptake by crotoxin, the major neurotoxin from Crotalus durissus terrificus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2004
This paper describes a brief study on the crotoxin mechanism of action, regarding the transport of GABA and L-glutamate in rats cortico-cerebral synaptosomes and in heterologous systems, such as COS-7 cells expressing gabaergic transporters, and C6 ...
A.L. Cecchini, A.M. Soares, J.R. Giglio, S. Amara, E.C. Arantes   +4 more
doaj   +1 more source

Biological and Medical Aspects Related to South American Rattlesnake Crotalus durissus (Linnaeus, 1758): A View from Colombia

Toxins, 2022
In Colombia, South America, there is a subspecies of the South American rattlesnake Crotalus durissus, C. d. cumanensis, a snake of the Viperidae family, whose presence has been reduced due to the destruction of its habitat. It is an enigmatic snake from
Carlos A. Cañas
doaj   +1 more source