Results 21 to 30 of about 1,959 (214)

Actions of Crotalus durissus terrificus venom and crotoxin on the isolated rat kidney

Brazilian Journal of Medical and Biological Research, 2001
Many studies have reported the occurrence of lethal acute renal failure after snakebites. The aim of the present investigation was to determine alterations in renal function produced by Crotalus durissus terrificus venom and crotoxin as well as the ...
H.S.A. Monteiro, I.M.S.C. da Silva, A.M.C. Martins, M.C. Fonteles   +3 more
doaj   +2 more sources

Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus.
Marco Aurélio Sartim, Danilo Luccas Menaldo, Suely Vilela Sampaio   +2 more
doaj   +2 more sources

Inhibition of L-glutamate and GABA synaptosome uptake by crotoxin, the major neurotoxin from Crotalus durissus terrificus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2004
This paper describes a brief study on the crotoxin mechanism of action, regarding the transport of GABA and L-glutamate in rats cortico-cerebral synaptosomes and in heterologous systems, such as COS-7 cells expressing gabaergic transporters, and C6 ...
A.L. Cecchini, A.M. Soares, J.R. Giglio, S. Amara, E.C. Arantes   +4 more
doaj   +2 more sources

Crystal Structure of Isoform CBd of the Basic Phospholipase A₂ Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets

Molecules, 2020
Crotoxin, from the venom of the South American rattlesnake Crotalus durissus terrificus, is a potent heterodimeric presynaptic β-neurotoxin that exists in individual snake venom as a mixture of isoforms of a basic phospholipase A2 (PLA2) subunit (CBa2 ...
Dorota Nemecz, Maciej Ostrowski, Marc Ravatin, Frederick Saul, Grazyna Faure   +4 more
doaj   +2 more sources

The antineoplastic potential of crotoxin isolated from Crotalus durissus terrificus snake venom on oral squamous cell carcinoma. [PDF]

Toxicon, 2022
This study investigated the antineoplastic effects of crotoxin isolated from snake venom of the South American Crotalus durissus terrificus in oral cancer cell lines and in an animal model of chemically induced oral cancer. We analyzed cell viability and
Rogério Gonçalves da Rocha, Eliane Macedo Sobrinho Santos, A. Tanaka-Azevedo, C. Serino-Silva, Marcela Gonçalves de Souza, Emisael Stênio Batista Gomes, F. A. Guimarães, Luiz Henrique Silveira, S. Santos, A. D. de Paula, R. Gomez, A. L. Guimarães, L. Farias   +12 more
semanticscholar   +2 more sources

The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions

Frontiers in Immunology, 2020
Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use.
Morena Brazil Sant'Anna, Aline C. Giardini, Marcio A. C. Ribeiro, Flavia S. R. Lopes, Nathalia B. Teixeira, Louise F. Kimura, Michelle C. Bufalo, Orlando G. Ribeiro, Andrea Borrego, Wafa H. K. Cabrera, Julio C. B. Ferreira, Julio C. B. Ferreira, Vanessa O. Zambelli, Vanessa O. Zambelli, Osvaldo A. Sant'Anna, Gisele Picolo   +15 more
doaj   +2 more sources

Crotoxin, the major toxin from the rattlesnake Crotalus durissus terrificus, inhibits ³H-choline uptake in guinea pig ileum

Brazilian Journal of Medical and Biological Research, 2000
We examined the effect of crotoxin, the neurotoxic complex from the venom of the South American rattlesnake Crotalus durissus terrificus, on the uptake of ³H-choline in minces of smooth muscle myenteric plexus from guinea pig ileum.
L.S. Kattah, M.M. Santoro, C.R. Diniz, M.E. De Lima   +3 more
doaj   +2 more sources

Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids

Biomolecules, 2020
Respiratory compromise in Crotalus durissus terrificus (C.d.t.) snakebite is an important pathological condition. Considering that crotoxin (CTX), a phospholipase A2 from C.d.t. venom, is the main component of the venom, the present work investigated the
Marco Aurelio Sartim, Camila O. S. Souza, Cassiano Ricardo A. F. Diniz, Vanessa M. B. da Fonseca, Lucas O. Sousa, Ana Paula F. Peti, Tassia Rafaella Costa, Alan G. Lourenço, Marcos C. Borges, Carlos A. Sorgi, Lucia Helena Faccioli, Suely Vilela Sampaio   +11 more
doaj   +2 more sources

Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. [PDF]

PLoS Neglected Tropical Diseases
BackgroundPhenotypic polymorphism in rattlesnake venoms is well-documented, with a dichotomy between hemorrhagic (Type I) and neurotoxic (Type II) venoms.
Mônica Colombini, Anderson M Rocha, Luciana A Freitas-de-Sousa, Alison F A Chaves, Solange M T Serrano, Vinicius C Souza, Vincent L Viala, Inácio L M Junqueira-Azevedo, Felipe A Cerni, Marco A Sartim, Jacqueline A G Sachett, Wuelton M Monteiro, Felipe G Grazziotin, Fan Hui Wen, Manuela B Pucca, Ana M Moura-da-Silva   +15 more
doaj   +2 more sources

Crotoxin: Novel activities for a classic beta-neurotoxin

Toxicon, 2010
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be purified and crystallized.
Hyslop, Stephen, Gutierrez, Vanessa P., Magro, Angelo J. [UNESP], Fontes, Marcos R. M., Zambelli, Vanessa O., Brigatte, Patricia, Sampaio, Sandra C., Prado-Franceschi, Julia, Cury, Yara, Fontes, Marcos R. M. [UNESP], Magro, Angelo J., Stephen Hyslop, Vanessa P. Gutierrez, Sandra C. Sampaio, Patrícia Brigatte, Vanessa O. Zambelli, Angelo J. Magro, Julia Prado-Franceschi, Yara Cury, Marcos R.M. Fontes   +19 more
core   +4 more sources