Results 21 to 30 of about 690 (160)

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Complex regional pain syndrome following southern Pacific rattlesnake (C. oreganus helleri) envenoming

Clinical Case Reports, Volume 9, Issue 11, November 2021., 2021
Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but might be more common than previously reported. We present the third case of CRPS reported in North America and the first resulting from a pit‐viper's bite. Abstract Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but
Lawrence McLean House, Matthew R Lewin, Ramana K. Naidu, Halil Beqaj   +3 more
wiley   +1 more source

Crotoxin Inhibits Endothelial Cell Functions in Two- and Three-dimensional Tumor Microenvironment

Frontiers in Pharmacology, 2021
Antitumor property of Crotoxin (CTX), the major toxin from Crotalus durissus terrificus snake venom, has been demonstrated in experimental animal models and clinical trials.
Ellen Emi Kato, Luciana Araújo Pimenta, Maíra Estanislau Soares de Almeida, Vanessa Olzon Zambelli, Marinilce Fagundes dos Santos, Sandra Coccuzzo Sampaio, Sandra Coccuzzo Sampaio   +6 more
doaj   +1 more source

Crotalic accidents in Brazil: actualities and perspectives

Revista Médica de Minas Gerais, 2022
Introduction: Ophidian accidents are neglected events in tropical and in developing countries, including Brazil. Serpents of the Crotalus genus (rattlesnakes) are those that produce the highest case-fatality in the country.
Hammer, Fernanda Martins, Feio, Renato Neves, Siqueira-Batista, Rodrigo   +2 more
doaj   +1 more source

Crotoxin Modulates Events Involved in Epithelial–Mesenchymal Transition in 3D Spheroid Model

Toxins, 2021
Epithelial–mesenchymal transition (EMT) occurs in the early stages of embryonic development and plays a significant role in the migration and the differentiation of cells into various types of tissues of an organism.
Ellen Emi Kato, Sandra Coccuzzo Sampaio
doaj   +1 more source

Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model

Toxins, 2020
The most abundant protein families in viper venoms are Snake Venom Metalloproteases (SVMPs), Snake Venom Serine Proteases (SVSPs) and Phospholipases (PLA2s).
Edgar Neri-Castro, Melisa Bénard-Valle, Dayanira Paniagua, Leslie V. Boyer, Lourival D. Possani, Fernando López-Casillas, Alejandro Olvera, Camilo Romero, Fernando Zamudio, Alejandro Alagón   +9 more
doaj   +1 more source

Inhibition of L-glutamate and GABA synaptosome uptake by crotoxin, the major neurotoxin from Crotalus durissus terrificus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2004
This paper describes a brief study on the crotoxin mechanism of action, regarding the transport of GABA and L-glutamate in rats cortico-cerebral synaptosomes and in heterologous systems, such as COS-7 cells expressing gabaergic transporters, and C6 ...
A.L. Cecchini, A.M. Soares, J.R. Giglio, S. Amara, E.C. Arantes   +4 more
doaj   +1 more source

Biological and Medical Aspects Related to South American Rattlesnake Crotalus durissus (Linnaeus, 1758): A View from Colombia

Toxins, 2022
In Colombia, South America, there is a subspecies of the South American rattlesnake Crotalus durissus, C. d. cumanensis, a snake of the Viperidae family, whose presence has been reduced due to the destruction of its habitat. It is an enigmatic snake from
Carlos A. Cañas
doaj   +1 more source

Detection and quantification of a β-neurotoxin (crotoxin homologs) in the venom of the rattlesnakes Crotalus simus, C. culminatus and C. tzabcan from Mexico

Toxicon: X, 2019
Snake venom may vary in composition and toxicity across the geographic distribution of a species. In the case of the three species of the Neotropical rattlesnakes Crotalus simus, C. culminatus and C. tzabcan recent research has revealed that their venoms
Edgar Neri-Castro, Arely Hernández-Dávila, Alejandro Olvera-Rodríguez, Héctor Cardoso-Torres, Melisa Bénard-Valle, Elizabeth Bastiaans, Oswaldo López-Gutierrez, Alejandro Alagón   +7 more
doaj   +1 more source

Actions of Crotalus durissus terrificus venom and crotoxin on the isolated rat kidney

Brazilian Journal of Medical and Biological Research, 2001
Many studies have reported the occurrence of lethal acute renal failure after snakebites. The aim of the present investigation was to determine alterations in renal function produced by Crotalus durissus terrificus venom and crotoxin as well as the ...
H.S.A. Monteiro, I.M.S.C. da Silva, A.M.C. Martins, M.C. Fonteles   +3 more
doaj   +1 more source