Results 11 to 20 of about 1,216 (181)

Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B

Acta Tropica, 2012
The antiplasmodial activity of phospholipases A(2) (PLA(2)) isolated from different animals has been studied. We explored the in vitro anti Plasmodium falciparum effect of a fraction containing crotoxin, Crotoxin B and whole venom of the rattlesnake Crotalus durissus cumanensis.
JOSÉ Maria Gutierrez, Cesar Segura, J M Gutierrez   +2 more
exaly   +8 more sources

Effect of gamma irradiation on the behavioral properties of crotoxin [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Crotoxin has been detoxified with gamma radiation in order to improve crotalic antiserum production. Nevertheless, present knowledge of the biological characteristics of irradiated crotoxin is insufficient to propose it as an immunizing agent.
E.G. Moreira, N. Nascimento, G.J.M. Rosa, J.R. Rogero, V.S. Vassilieff   +4 more
doaj   +7 more sources

Crotoxin: Novel activities for a classic β-neurotoxin

Toxicon, 2010
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be purified and crystallized. Crotoxin is a heterodimeric beta-neurotoxin that consists of a weakly toxic basic phospholipase A(2) and a non-enzymatic, non-toxic acidic component (crotapotin).
Sandra Sampaio, Fontes Marcos R M, Yara Cury   +2 more
exaly   +5 more sources

Actions of Crotalus durissus terrificus venom and crotoxin on the isolated rat kidney

Brazilian Journal of Medical and Biological Research, 2001
Many studies have reported the occurrence of lethal acute renal failure after snakebites. The aim of the present investigation was to determine alterations in renal function produced by Crotalus durissus terrificus venom and crotoxin as well as the ...
H.S.A. Monteiro, I.M.S.C. da Silva, A.M.C. Martins, M.C. Fonteles   +3 more
doaj   +2 more sources

Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus.
Marco Aurélio Sartim, Danilo Luccas Menaldo, Suely Vilela Sampaio   +2 more
doaj   +2 more sources

Snake Venom PLA₂ as Anticoagulant Agents: Role of Crotoxin, from Crotalus durissus Rattlesnake, in Hemostasis [PDF]

Toxins
Snake venoms are rich sources of bioactive molecules that modulate hemostasis and, among these, anticoagulant snake venom phospholipases A2 (sPLA2) are found in a range of snake venoms.
Lisele Maria Brasileiro-Martins, Greene Dias Marques, Jéssica Burlamaque Maciel, Márcia Neiva, Thaís Pinto Nascimento, David Jose Estrada Reyes, Alessandro Júnio Campelo Feitosa, Sofia Angiole-Cavalcante, Priscila Ferreira de Aquino, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro, Marco Aurélio Sartim   +11 more
doaj   +2 more sources

Inhibition of L-glutamate and GABA synaptosome uptake by crotoxin, the major neurotoxin from Crotalus durissus terrificus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2004
This paper describes a brief study on the crotoxin mechanism of action, regarding the transport of GABA and L-glutamate in rats cortico-cerebral synaptosomes and in heterologous systems, such as COS-7 cells expressing gabaergic transporters, and C6 ...
A.L. Cecchini, A.M. Soares, J.R. Giglio, S. Amara, E.C. Arantes   +4 more
doaj   +2 more sources

Crotoxin Modulates Events Involved in Epithelial–Mesenchymal Transition in 3D Spheroid Model [PDF]

Toxins, 2021
Epithelial–mesenchymal transition (EMT) occurs in the early stages of embryonic development and plays a significant role in the migration and the differentiation of cells into various types of tissues of an organism.
Ellen Emi Kato, Sandra Coccuzzo Sampaio
doaj   +2 more sources

Immunorecognition and Neutralization of Crotalus durissus cumanensis Venom by a Commercial Antivenom Produced in Colombia [PDF]

Toxins, 2022
In Colombia, on average 2.9% of the nearly 5600 snakebite events that occur annually involve the rattlesnake Crotalus durissus cumanensis. The envenomation by this snake is mainly characterized by neurotoxicity and the main toxin is crotoxin (~64.7% of ...
Augusto Acosta-Peña, Vitelbina Núñez, Jaime Andres Pereañez, Paola Rey-Suárez   +3 more
doaj   +2 more sources

Detection and quantification of a β-neurotoxin (crotoxin homologs) in the venom of the rattlesnakes Crotalus simus, C. culminatus and C. tzabcan from Mexico

Toxicon: X, 2019
Snake venom may vary in composition and toxicity across the geographic distribution of a species. In the case of the three species of the Neotropical rattlesnakes Crotalus simus, C. culminatus and C. tzabcan recent research has revealed that their venoms
Melisa Bénard-Valle, Elizabeth Bastiaans, Gerardo Corzo   +2 more
exaly   +3 more sources