Results 11 to 20 of about 686 (159)

Snake Venom PLA₂ as Anticoagulant Agents: Role of Crotoxin, from Crotalus durissus Rattlesnake, in Hemostasis [PDF]

Toxins
Snake venoms are rich sources of bioactive molecules that modulate hemostasis and, among these, anticoagulant snake venom phospholipases A2 (sPLA2) are found in a range of snake venoms.
Lisele Maria Brasileiro-Martins, Greene Dias Marques, Jéssica Burlamaque Maciel, Márcia Neiva, Thaís Pinto Nascimento, David Jose Estrada Reyes, Alessandro Júnio Campelo Feitosa, Sofia Angiole-Cavalcante, Priscila Ferreira de Aquino, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro, Marco Aurélio Sartim   +11 more
doaj   +2 more sources

Crotoxin induces cytotoxic effects in human malignant melanoma cells in both native and detoxified forms [PDF]

Frontiers in Pharmacology
Introduction: Melanoma, a highly aggressive skin cancer originating in melanocytes, poses a significant threat due to its metastatic potential. While progress has been made in treating melanoma with targeted therapies and immunotherapies, challenges ...
Tamires Cunha Almeida, Karina Cristina Giannotti, Lorena Morais Ribeiro Silva, Rafael Marques-Porto, Carlos DeOcesano-Pereira, Lauren Camargo, Ana Marisa Chudzinski-Tavassi, Paul Reid, Gisele Picolo   +8 more
doaj   +2 more sources

Crotoxin Modulates Events Involved in Epithelial–Mesenchymal Transition in 3D Spheroid Model [PDF]

Toxins, 2021
Epithelial–mesenchymal transition (EMT) occurs in the early stages of embryonic development and plays a significant role in the migration and the differentiation of cells into various types of tissues of an organism.
Ellen Emi Kato, Sandra Coccuzzo Sampaio
doaj   +2 more sources

Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B

Acta Tropica, 2012
The antiplasmodial activity of phospholipases A(2) (PLA(2)) isolated from different animals has been studied. We explored the in vitro anti Plasmodium falciparum effect of a fraction containing crotoxin, Crotoxin B and whole venom of the rattlesnake Crotalus durissus cumanensis.
Cesar Segura, José Maria Gutierrez
exaly   +5 more sources

Immunorecognition and Neutralization of Crotalus durissus cumanensis Venom by a Commercial Antivenom Produced in Colombia [PDF]

Toxins, 2022
In Colombia, on average 2.9% of the nearly 5600 snakebite events that occur annually involve the rattlesnake Crotalus durissus cumanensis. The envenomation by this snake is mainly characterized by neurotoxicity and the main toxin is crotoxin (~64.7% of ...
Augusto Acosta-Peña, Vitelbina Núñez, Jaime Andres Pereañez, Paola Rey-Suárez   +3 more
doaj   +2 more sources

Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. [PDF]

PLoS Neglected Tropical Diseases
BackgroundPhenotypic polymorphism in rattlesnake venoms is well-documented, with a dichotomy between hemorrhagic (Type I) and neurotoxic (Type II) venoms.
Mônica Colombini, Anderson M Rocha, Luciana A Freitas-de-Sousa, Alison F A Chaves, Solange M T Serrano, Vinicius C Souza, Vincent L Viala, Inácio L M Junqueira-Azevedo, Felipe A Cerni, Marco A Sartim, Jacqueline A G Sachett, Wuelton M Monteiro, Felipe G Grazziotin, Fan Hui Wen, Manuela B Pucca, Ana M Moura-da-Silva   +15 more
doaj   +2 more sources

Intraspecific Differences in the Venom of Crotalus durissus cumanensis from Colombia [PDF]

Toxins, 2022
Biochemical and biological differences in the venom of Crotalus durissus cumanensis from three ecoregions of Colombia were evaluated. Rattlesnakes were collected from the geographic areas of Magdalena Medio (MM), Caribe (CA) and Orinoquía (OR). All three
Ariadna Rodríguez-Vargas, Nohora Vega, Edgar Reyes-Montaño, Gerardo Corzo, Edgar Neri-Castro, Herlinda Clement, Francisco Ruiz-Gómez   +6 more
doaj   +2 more sources

3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line [PDF]

Molecules
Breast cancer stands as the most prevalent type of tumor and a significant contributor to cancer-related deaths. Among its various subtypes, triple-negative breast cancer (TNBC) presents the worst prognosis due to its aggressive nature and the absence of
Patricia Bezerra, Eduardo F. Motti
doaj   +2 more sources

Crotoxin: Novel activities for a classic β-neurotoxin

Toxicon, 2010
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be purified and crystallized. Crotoxin is a heterodimeric beta-neurotoxin that consists of a weakly toxic basic phospholipase A(2) and a non-enzymatic, non-toxic acidic component (crotapotin).
Stephen Hyslop, Marcos R M Fontes, Vanessa O Zambelli   +2 more
exaly   +4 more sources

Effects of the Heterodimeric Neurotoxic Phospholipase A₂ from the Venom of Vipera nikolskii on the Contractility of Rat Papillary Muscles and Thoracic Aortas [PDF]

Toxins
Phospholipases A2 (PLA2s) are a large family of snake toxins manifesting diverse biological effects, which are not always related to phospholipolytic activity.
Alexey Averin, Vladislav Starkov, Victor Tsetlin, Yuri Utkin   +3 more
doaj   +2 more sources