Crotoxin-Loaded Silica Nanoparticles: A Nanovenom Approach [PDF]
PharmaceuticsBackground: Ophidism is a globally neglected health problem. In Argentina, Crotalus durissus terrificus (C.d.t., South American rattlesnake) is one of the species of greatest medical importance since its venom contains mainly crotoxin (CTX), a potent ...
Florencia Silvina Conti +5 more
doaj +5 more sources
Oral Nano-Delivery of Crotoxin Modulates Experimental Ulcerative Colitis in a Mouse Model of Maximum Acute Inflammatory Response. [PDF]
Int J Mol SciThe incorporation of drugs into nanostructured silica has proven to be an effective strategy for delaying drug release, protecting against enzymatic degradation, and enhancing therapeutic efficacy.
de Oliveira Brito RG +14 more
europepmc +3 more sources
HETEROLOGOUS EXPRESSION AND PURIFICATION OF RECOMBINANT CROTOXIN B, THE PHOSPHOLIPASE A2 SUBUNIT OF CROTOXIN [PDF]
Studia Universitatis Babes-Bolyai Chemia, 2018 Crotoxin is a heterodimeric β-neurotoxin isolated from the venom of Crotalus durissus terrificus, consisting of two, non-covalently bound subunits, crotapotin (CA) and crotoxin B (CB).
Francisc-Andrei BODA +6 more
doaj +3 more sources
Effect of gamma irradiation on the behavioral properties of crotoxin [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Crotoxin has been detoxified with gamma radiation in order to improve crotalic antiserum production. Nevertheless, present knowledge of the biological characteristics of irradiated crotoxin is insufficient to propose it as an immunizing agent.
E.G. Moreira +4 more
doaj +7 more sources
3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line [PDF]
MoleculesBreast cancer stands as the most prevalent type of tumor and a significant contributor to cancer-related deaths. Among its various subtypes, triple-negative breast cancer (TNBC) presents the worst prognosis due to its aggressive nature and the absence of
Patricia Bezerra, Eduardo F. Motti
doaj +3 more sources
Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B
Acta Tropica, 2012 The antiplasmodial activity of phospholipases A2 (PLA2) isolated from different animals has been studied. We explored the in vitro anti Plasmodium falciparum effect of a fraction containing crotoxin, Crotoxin B and whole venom of the rattlesnake Crotalus
Quintana Castillo, Juan carlos +5 more
core +7 more sources
Crotoxin Elicits Differential Increases in Macrophage Lipid Droplet Formation In Vitro Modulated during <i>Leishmania (Leishmania) amazonensis</i> Infection. [PDF]
ACS OmegaLeishmania spp. is an obligate intracellular parasite that primarily infects macrophages. During infection, leukocytes are activated, culminating in the formation of lipid droplets (LDs), which are sites for the synthesis of eicosanoids that modulate the
Ávila LT +8 more
europepmc +2 more sources
Crotoxin Inhibits Endothelial Cell Functions in Two- and Three-dimensional Tumor Microenvironment
Frontiers in Pharmacology, 2021 Antitumor property of Crotoxin (CTX), the major toxin from Crotalus durissus terrificus snake venom, has been demonstrated in experimental animal models and clinical trials.
Ellen Emi Kato +6 more
doaj +2 more sources
Crotoxin Modulates Events Involved in Epithelial–Mesenchymal Transition in 3D Spheroid Model
Toxins, 2021 Epithelial–mesenchymal transition (EMT) occurs in the early stages of embryonic development and plays a significant role in the migration and the differentiation of cells into various types of tissues of an organism.
Ellen Emi Kato, Sandra Coccuzzo Sampaio
doaj +2 more sources
Toxicon: X, 2019 Snake venom may vary in composition and toxicity across the geographic distribution of a species. In the case of the three species of the Neotropical rattlesnakes Crotalus simus, C. culminatus and C. tzabcan recent research has revealed that their venoms
Edgar Neri-Castro +7 more
doaj +2 more sources