Crotoxin-Loaded Silica Nanoparticles: A Nanovenom Approach [PDF]
PharmaceuticsBackground: Ophidism is a globally neglected health problem. In Argentina, Crotalus durissus terrificus (C.d.t., South American rattlesnake) is one of the species of greatest medical importance since its venom contains mainly crotoxin (CTX), a potent ...
Florencia Silvina Conti +5 more
doaj +4 more sources
Studia Universitatis Babes-Bolyai Chemia, 2018 Crotoxin is a heterodimeric β-neurotoxin isolated from the venom of Crotalus durissus terrificus, consisting of two, non-covalently bound subunits, crotapotin (CA) and crotoxin B (CB).
Francisc-Andrei BODA +6 more
doaj +2 more sources
Effect of gamma irradiation on the behavioral properties of crotoxin [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Crotoxin has been detoxified with gamma radiation in order to improve crotalic antiserum production. Nevertheless, present knowledge of the biological characteristics of irradiated crotoxin is insufficient to propose it as an immunizing agent.
E.G. Moreira +4 more
doaj +5 more sources
Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations. [PDF]
PLoS Neglected Tropical DiseasesBackgroundPhenotypic polymorphism in rattlesnake venoms is well-documented, with a dichotomy between hemorrhagic (Type I) and neurotoxic (Type II) venoms.
Mônica Colombini +15 more
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Intraspecific Differences in the Venom of Crotalus durissus cumanensis from Colombia [PDF]
Toxins, 2022 Biochemical and biological differences in the venom of Crotalus durissus cumanensis from three ecoregions of Colombia were evaluated. Rattlesnakes were collected from the geographic areas of Magdalena Medio (MM), Caribe (CA) and Orinoquía (OR). All three
Ariadna Rodríguez-Vargas +6 more
doaj +2 more sources
3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line [PDF]
MoleculesBreast cancer stands as the most prevalent type of tumor and a significant contributor to cancer-related deaths. Among its various subtypes, triple-negative breast cancer (TNBC) presents the worst prognosis due to its aggressive nature and the absence of
Patricia Bezerra, Eduardo F. Motti
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Effects of the Heterodimeric Neurotoxic Phospholipase A2 from the Venom of Vipera nikolskii on the Contractility of Rat Papillary Muscles and Thoracic Aortas [PDF]
ToxinsPhospholipases A2 (PLA2s) are a large family of snake toxins manifesting diverse biological effects, which are not always related to phospholipolytic activity.
Alexey Averin +3 more
doaj +2 more sources
Journal of Immunology Research, 2018 The Crotalus durissus terrificus rattlesnake venom, its main toxin, crotoxin (CTX), and its crotapotin (CA) and phospholipase A2 (CB) subunits modulate the immune system.
A. P. Freitas +4 more
doaj +2 more sources
Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4
Mediators of Inflammation, 2016 We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte +7 more
doaj +2 more sources
The Proteome of African Spitting and Non-Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells. [PDF]
J Appl ToxicolABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Offor BC +3 more
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