Results 41 to 50 of about 1,959 (214)

Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model

Toxins, 2020
The most abundant protein families in viper venoms are Snake Venom Metalloproteases (SVMPs), Snake Venom Serine Proteases (SVSPs) and Phospholipases (PLA2s).
Edgar Neri-Castro, Melisa Bénard-Valle, Dayanira Paniagua, Leslie V. Boyer, Lourival D. Possani, Fernando López-Casillas, Alejandro Olvera, Camilo Romero, Fernando Zamudio, Alejandro Alagón   +9 more
doaj   +1 more source

Biological and Medical Aspects Related to South American Rattlesnake Crotalus durissus (Linnaeus, 1758): A View from Colombia

Toxins, 2022
In Colombia, South America, there is a subspecies of the South American rattlesnake Crotalus durissus, C. d. cumanensis, a snake of the Viperidae family, whose presence has been reduced due to the destruction of its habitat. It is an enigmatic snake from
Carlos A. Cañas
doaj   +1 more source

Structural studies with crotoxin B from Crotalus durissus collilineatus venom suggest a heterodimeric assembly formed by two new isoforms.

Biochimie, 2023
In accidents involving Crotalus snakes, the crotoxin complex (CTX) plays lethal action due to its neurotoxic activity. On the other hand, CTX have potential biotechnological application due to its anti-tumoral, anti-inflammatory, antimicrobial, analgesic
G. Salvador, C. Fernandes, Rafael J. Borges, A. Soares, Marcos R. M. Fontes   +4 more
semanticscholar   +1 more source

Mapping possible interaction sites for crotoxin in CNF, a gamma PLA2 inhibitor from Crotalus durissus terrificus rattle snake, using SPOT synthesis.

Toxicon, 2023
Phospholipases A2 (PLA2s) are main components of snake venoms. Several snake species possess endogenous PLA2 inhibitors in their circulating blood, which are generally known as sbPLIs (an acronym for snake blood phospholipase A2inhibitors).
P. Campos, Hamine Cristina de Oliveira, P. L. Ortolani, Lutiana Amaral de Melo, Marcos R. M. Fontes, C. L. Fortes-Dias   +5 more
semanticscholar   +1 more source

Crotoxin-induced behavioral effects in rats

, 1996
Crotoxin is the major component of Crotalus durissus terrificus venom. In view of the presence of high-affinity specific binding sites for crotoxin in the brain, the objective of this work was to investigate whether crotoxin induces behavioral effects in
Moreira, E. G., Rosa, GJM, Vassilieff, V. S., Rogero, JR, Nascimento, N.   +4 more
core   +3 more sources

Biological Roles of the Two Components of Crotoxin [PDF]

Proceedings of the National Academy of Sciences, 1971
Crotoxin, the Brazilian rattlesnake neurotoxin, generally behaves as a homogeneous protein; however, it is a molecular complex of an acidic and a basic protein. These can be separated after alkylation or acylation of the amino groups, or on carboxymethyl cellulose at pH 4, or on DEAE-cellulose in 6 M urea. The two proteins differ greatly in composition,
R A, Hendon, H, Fraenkel-Conrat
openaire   +2 more sources

Crotoxin modulates inflammation and macrophages' functions in a murine sepsis model.

Toxicon, 2022
Sepsis is a syndrome of physiologic and biochemical abnormalities induced by an infection that represents a major public health concern. It involves the early activation of inflammatory responses.
Marisa Langeani Bretones, S. C. Sampaio, D. Barbeiro, S. Ariga, F. Soriano, T. M. de Lima   +5 more
semanticscholar   +1 more source

Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

Journal of Molecular Biology, 2022
We have previously shown that the CBb subunit of crotoxin, a β-neurotoxin with phospholipase A2 (PLA2) activity, targets the human ΔF508CFTR chloride channel implicated in cystic fibrosis (CF).
Marc Ravatin, Norbert Odolczyk, N. Servel, J. Guijarro, Eric Tagat, B. Chevalier, N. Baatallah, P. Corringer, G. Lukács, A. Edelman, P. Zielenkiewicz, J. Chambard, A. Hinzpeter, G. Faure   +13 more
semanticscholar   +1 more source

Anti-sera raised in rabbits against crotoxin and phospholipase A(2) from Crotalus durissus cascavella venom neutralize the neurotoxicity of the venom and crotoxin

, 2015
Crotoxin, the principal neurotoxin in venom of the South American rattlesnakes Crotalus durissus terrificus and Crotalus durissus cascavella, contains a basic phospholipase A(2) (PLA(2)) and an acidic protein, crotapotin.
Hyslop, Stephen, Hernandez-Oliveira, S, Hyslop, S, Marangoni, Sérgio, Beghini, DG, Marangoni, S, Hernandez-Oliveira, Saraguaci, Novello, José Camilo, Rodrigues-Simioni, L, Novello, JC, Beghini, Daniela G, Rodrigues-Simioni, Léa   +11 more
core   +2 more sources

Clinical, Laboratory, and Therapeutic Aspects of Crotalus durissus (South American Rattlesnake) Victims: A Literature Review

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Snakebite envenoming is a neglected public health issue in many tropical and subtropical countries. To diagnosis and treat snakebites may be challenging to health care personnel since sufficient information has not been yet provided. This review presents the clinical, therapeutic, and laboratory aspects of Crotalus durissus (South American rattlesnakes)
Bruno Tumang Frare, Yann Keller Silva Resende, Bruno de Carvalho Dornelas, Miguel Tannus Jorge, Valter Augusto Souza Ricarte, Lívia Maria Alves, Luiz Fernando Moreira Izidoro, Giuseppe Piccione   +7 more
wiley   +1 more source