Results 41 to 50 of about 1,216 (181)

Crotalus durissus terrificus venom as a source of antitumoral agents

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase ...
MA Soares, PB Pujatti, CL Fortes-Dias, L Antonelli, RG Santos   +4 more
doaj   +1 more source

Crotalus durissus ruruima Snake Venom and a Phospholipase A2 Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Viper snake Crotalus durissus ruruima (Cdr) is a subspecies found in northern area of Brazil. Among the snakes of Crotalus genus subspecies, the venom of Cdr presents highest level of crotoxin, which is the major component of Crotalus snake venoms, formed by two subunits (crotapotin and a phospholipase A2 named CBr) and presents potent neurotoxic ...
Ana Eduarda Zulim de Carvalho, Karina Giannotti, Elbio Leiguez Junior, Márcio Matsubara, Maria Cristina Dos Santos, Consuelo Latorre Fortes-Dias, Catarina Teixeira, Benoit Stijlemans   +7 more
wiley   +1 more source

Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Natural products with antispasmodic activity have been used in traditional medicine to alleviate different illnesses since the remote past. We searched the literature and compiled the antispasmodic activity of 248 natural compounds isolated from terrestrial plants.
Edith Fabiola Martínez-Pérez, Zaida N. Juárez, Luis R. Hernández, Horacio Bach, Juergen Buenger   +4 more
wiley   +1 more source

Camelid Single-Domain Antibodies (VHHs) against Crotoxin: A Basis for Developing Modular Building Blocks for the Enhancement of Treatment or Diagnosis of Crotalic Envenoming

Toxins, 2018
Toxic effects triggered by crotalic envenoming are mainly related to crotoxin (CTX), composed of a phospholipase A2 (CB) and a subunit with no toxic activity (CA).
Marcos B. Luiz, Soraya S. Pereira, Nidiane D. R. Prado, Naan R. Gonçalves, Anderson M. Kayano, Leandro S. Moreira-Dill, Juliana C. Sobrinho, Fernando B. Zanchi, André L. Fuly, Cleberson F. Fernandes, Juliana P. Zuliani, Andreimar M. Soares, Rodrigo G. Stabeli, Carla F. C. Fernandes   +13 more
doaj   +1 more source

Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids

Biomolecules, 2020
Respiratory compromise in Crotalus durissus terrificus (C.d.t.) snakebite is an important pathological condition. Considering that crotoxin (CTX), a phospholipase A2 from C.d.t. venom, is the main component of the venom, the present work investigated the
Marco Aurelio Sartim, Camila O. S. Souza, Cassiano Ricardo A. F. Diniz, Vanessa M. B. da Fonseca, Lucas O. Sousa, Ana Paula F. Peti, Tassia Rafaella Costa, Alan G. Lourenço, Marcos C. Borges, Carlos A. Sorgi, Lucia Helena Faccioli, Suely Vilela Sampaio   +11 more
doaj   +1 more source

The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions

Frontiers in Immunology, 2020
Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use.
Morena Brazil Sant'Anna, Aline C. Giardini, Marcio A. C. Ribeiro, Flavia S. R. Lopes, Nathalia B. Teixeira, Louise F. Kimura, Michelle C. Bufalo, Orlando G. Ribeiro, Andrea Borrego, Wafa H. K. Cabrera, Julio C. B. Ferreira, Julio C. B. Ferreira, Vanessa O. Zambelli, Vanessa O. Zambelli, Osvaldo A. Sant'Anna, Gisele Picolo   +15 more
doaj   +1 more source

Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price.
Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang, Ji-Fu Wei   +5 more
wiley   +1 more source

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2017
Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and unsaturated fatty acids, agents that can damage membranes.
Catherine A Vulfius, Igor E Kasheverov, Elena V Kryukova, Ekaterina N Spirova, Irina V Shelukhina, Vladislav G Starkov, Tatyana V Andreeva, Grazyna Faure, Marios Zouridakis, Victor I Tsetlin, Yuri N Utkin   +10 more
doaj   +1 more source

Ethnopharmacological Survey of Medicinal Plants Used by Traditional Healers and Indigenous People in Chittagong Hill Tracts, Bangladesh, for the Treatment of Snakebite

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
Snakebites are common in tropical countries like Bangladesh where most snakebite victims dwell in rural areas. Among the management options after snakebite in Bangladesh, snake charmers (Ozha in Bengali language) are the first contact following a snakebite for more than 80% of the victims and they are treated mostly with the help of some medicinal ...
Mohammad Fahim Kadir, James Regun Karmoker, Md. Rashedul Alam, Syeda Rawnak Jahan, Sami Mahbub, M. M. K. Mia, Rainer W. Bussmann   +6 more
wiley   +1 more source

Elaborating the Role of Natural Products‐Induced Autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Autophagy is a homeostatic process that is highly conserved across different types of mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress during the rapid expansion of cancer. Excessive and sustained autophagy may lead to cell death and tumor shrinkage.
Ning Wang, Yibin Feng, Beata Pająk
wiley   +1 more source