Results 41 to 50 of about 686 (159)
Toxins, 2018 Toxic effects triggered by crotalic envenoming are mainly related to crotoxin (CTX), composed of a phospholipase A2 (CB) and a subunit with no toxic activity (CA).
Marcos B. Luiz +13 more
doaj +1 more source
Biomolecules, 2020 Respiratory compromise in Crotalus durissus terrificus (C.d.t.) snakebite is an important pathological condition. Considering that crotoxin (CTX), a phospholipase A2 from C.d.t. venom, is the main component of the venom, the present work investigated the
Marco Aurelio Sartim +11 more
doaj +1 more source
Frontiers in Immunology, 2020 Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use.
Morena Brazil Sant'Anna +15 more
doaj +1 more source
Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development
BioMed Research International, Volume 2017, Issue 1, 2017., 2017 Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price.
Huixiang Xiao +5 more
wiley +1 more source
Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2017 Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and unsaturated fatty acids, agents that can damage membranes.
Catherine A Vulfius +10 more
doaj +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015 Snakebites are common in tropical countries like Bangladesh where most snakebite victims dwell in rural areas. Among the management options after snakebite in Bangladesh, snake charmers (Ozha in Bengali language) are the first contact following a snakebite for more than 80% of the victims and they are treated mostly with the help of some medicinal ...
Mohammad Fahim Kadir +6 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Autophagy is a homeostatic process that is highly conserved across different types of mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress during the rapid expansion of cancer. Excessive and sustained autophagy may lead to cell death and tumor shrinkage.
Ning Wang, Yibin Feng, Beata Pająk
wiley +1 more source
Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a ...
Leonardo A. Calderon +14 more
wiley +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin.
Laudicéia Alves de Oliveira +6 more
doaj +1 more source
Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents
Biochemistry Research International, Volume 2026, Issue 1, 2026.Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago +6 more
wiley +1 more source