Results 41 to 50 of about 690 (160)
Frontiers in Immunology, 2020 Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use.
Morena Brazil Sant'Anna +15 more
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Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development
BioMed Research International, Volume 2017, Issue 1, 2017., 2017 Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price.
Huixiang Xiao +5 more
wiley +1 more source
Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2017 Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and unsaturated fatty acids, agents that can damage membranes.
Catherine A Vulfius +10 more
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Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015 Snakebites are common in tropical countries like Bangladesh where most snakebite victims dwell in rural areas. Among the management options after snakebite in Bangladesh, snake charmers (Ozha in Bengali language) are the first contact following a snakebite for more than 80% of the victims and they are treated mostly with the help of some medicinal ...
Mohammad Fahim Kadir +6 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Autophagy is a homeostatic process that is highly conserved across different types of mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress during the rapid expansion of cancer. Excessive and sustained autophagy may lead to cell death and tumor shrinkage.
Ning Wang, Yibin Feng, Beata Pająk
wiley +1 more source
Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a ...
Leonardo A. Calderon +14 more
wiley +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin.
Laudicéia Alves de Oliveira +6 more
doaj +1 more source
Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents
Biochemistry Research International, Volume 2026, Issue 1, 2026.Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago +6 more
wiley +1 more source
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 This paper shows the results of quercitrin effects on the structure and biological activity of secretory phospholipase (sPLA2) from Crotalus durissus terrificus, which is the main toxin involved in the pharmacological effects of this snake venom. According to our mass spectrometry and circular dichroism results, quercetin was able to promote a chemical
Daniela de Oliveira Toyama +9 more
wiley +1 more source
Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae)
International Scholarly Research Notices, Volume 2014, Issue 1, 2014., 2014 Eclipta alba can be found growing wild in fallow lands of Bangladesh where it is considered as a weed by farmers. Traditional medicinal systems of the Indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract ...
Rownak Jahan +4 more
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