Results 61 to 70 of about 686 (159)

A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities

Revista do Instituto de Medicina Tropical de São Paulo, 1992
A mionecrose é um dos efeitos causados pelo veneno de Bothrops jararacussu. Uma miotoxina com homologia estrutural à fosfolipase A2 (PLA2), mas sem atividade enzimática, foi isolada desse veneno.
Maria Cristina dos-Santos, Luís Roberto de Camargo Gonçalves, Consuelo L. Fortes-Dias, Yara Cury, José Maria Gutiérrez, Maria de Fátima D. Furtado   +5 more
doaj   +1 more source

Correlating biological activity to thermo-structural analysis of the interaction of CTX with synthetic models of macrophage membranes

Scientific Reports, 2021
The important pharmacological actions of Crotoxin (CTX) on macrophages, the main toxin in the venom of Crotalus durissus terrificus, and its important participation in the control of different pathophysiological processes, have been demonstrated.
Luciana de Araújo Pimenta, Evandro L. Duarte, Gabriel S. Vignoli Muniz, Kerly Fernanda Mesquita Pasqualoto, Marcos Roberto de Mattos Fontes, M. Teresa Lamy, Sandra Coccuzzo Sampaio   +6 more
doaj   +1 more source

Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions

Mediators of Inflammation, 2001
Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2.
Diva F. Cardoso, Monica Lopes-Ferreira, Eliana L. Faquim-Mauro, Mahasti S. Macedo, Sandra H. P. Farsky   +4 more
doaj   +1 more source

Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle. [PDF]

PLoS ONE, 2017
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described.
Jacqueline Farinha Shimizu, Carina Machado Pereira, Cintia Bittar, Mariana Nogueira Batista, Guilherme Rodrigues Fernandes Campos, Suely da Silva, Adélia Cristina Oliveira Cintra, Carsten Zothner, Mark Harris, Suely Vilela Sampaio, Victor Hugo Aquino, Paula Rahal, Ana Carolina Gomes Jardim   +12 more
doaj   +1 more source

Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper ...
Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto   +7 more
doaj   +1 more source

Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice

Toxins, 2019
Neuropathic pain is a disease caused by structural and functional plasticity in central and peripheral sensory pathways that produce alterations in nociceptive processing.
Morena Brazil Sant’Anna, Flavia Souza Ribeiro Lopes, Louise Faggionato Kimura, Aline Carolina Giardini, Osvaldo Augusto Sant’Anna, Gisele Picolo   +5 more
doaj   +1 more source

Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study

Toxins, 2018
The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological
Juan Carlos Quintana-Castillo, Leidy Johana Vargas, Cesar Segura, Sebastián Estrada-Gómez, Julio César Bueno-Sánchez, Juan Carlos Alarcón   +5 more
doaj   +1 more source

Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study

Contemporary Clinical Trials Communications, 2017
Introduction: Crotoxin has a broad antitumor activity but has shown frequent neurotoxic toxicity. To induce tolerance and limit this toxicity, we propose a new design with intra-patient dose escalation.
Jacques Medioni, Mara Brizard, Reza Elaidi, Paul F. Reid, Khadija Benlhassan, Dorothy Bray   +5 more
doaj   +1 more source

Single-step purification of crotapotin and crotactine from Crotalus durissus terrificus venom using preparative isoelectric focusing

Brazilian Journal of Medical and Biological Research, 1997
We describe the isolation of crotoxin, a presynaptic B-neurotoxin, as well as its subunits B (crotactine) and A (crotapotin) from lyophilized Crotalus durissus terrificus venom by a single-step preparative isoelectric focusing procedure.
A.S. Aguiar, A.R. Melgarejo, C.R. Alves, S. Giovanni-De-Simone   +3 more
doaj   +1 more source

Identification, description and structural analysis of beta phospholipase A2 inhibitors (sbβPLIs) from Latin American pit vipers indicate a binding site region for basic snake venom phospholipases A2

Toxicon: X, 2019
Several snake species possess, in their circulating blood, endogenous PLA2 inhibitors (sbPLIs) with the primary function of natural protection against toxic enzymes from homologous and heterologous venoms.
Consuelo Latorre Fortes-Dias, Carlos Alexandre H. Fernandes, Paula Ladeira Ortolani, Patrícia Cota Campos, L.A. Melo, Liza Figueiredo Felicori, Marcos Roberto M. Fontes   +6 more
doaj   +1 more source