Results 71 to 80 of about 1,216 (181)

Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions

Mediators of Inflammation, 2001
Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2.
Diva F. Cardoso, Monica Lopes-Ferreira, Eliana L. Faquim-Mauro, Mahasti S. Macedo, Sandra H. P. Farsky   +4 more
doaj   +1 more source

Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle. [PDF]

PLoS ONE, 2017
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described.
Jacqueline Farinha Shimizu, Carina Machado Pereira, Cintia Bittar, Mariana Nogueira Batista, Guilherme Rodrigues Fernandes Campos, Suely da Silva, Adélia Cristina Oliveira Cintra, Carsten Zothner, Mark Harris, Suely Vilela Sampaio, Victor Hugo Aquino, Paula Rahal, Ana Carolina Gomes Jardim   +12 more
doaj   +1 more source

Neurotoxic and myotoxic actions of crotoxin-like and Crotalus durissus cascavella whole venom in the chick biventer cervicis preparation

, 2015
Crotoxin from Crotalus durissus cascavella venom was purified by a combination of molecular exclusion chromatography (Superdex 75 column) and HPLC molecular exclusion (Protein Pack 300SW column). Neurotoxic and myotoxic effects from C.
Beghini, DG, Marangoni, S, Rodrigues-Simioni, L, Novello, JC, da Cruz-Hofling, MA, Toyama, MH   +5 more
core   +2 more sources

Ability of rabbit antiserum against crotapotin to neutralize the neurotoxic, myotoxic and phospholipase A(2) activities of crotoxin from Crotalus durissus cascavella snake venom

, 2015
The toxicity of crotoxin, the major toxin of Crotalus durissus terrificus (South American rattlesnake) venom, is mediated by its basic phospholipase A(2) (PLA(2)) subunit. This PLA(2) is non-covalently associated with crotapotin, an acidic, enzymatically
Hyslop, S, Delatorre, MC, Beghini, DG, Marangoni, S, Rodrigues-Simioni, L, Damico, DCS, da Cruz-Hofling, MA   +6 more
core   +2 more sources

Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper ...
Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto   +7 more
doaj   +1 more source

Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice

Toxins, 2019
Neuropathic pain is a disease caused by structural and functional plasticity in central and peripheral sensory pathways that produce alterations in nociceptive processing.
Morena Brazil Sant’Anna, Flavia Souza Ribeiro Lopes, Louise Faggionato Kimura, Aline Carolina Giardini, Osvaldo Augusto Sant’Anna, Gisele Picolo   +5 more
doaj   +1 more source

Preliminary X-ray crystallographic studies of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom [PDF]

, 2007
Crotoxin B is a basic phospholipase A(2) found in the venom of Crotalus durissus terrificus and is one of the subunits that constitute crotoxin. This heterodimeric toxin, which is the main component of C. d.
Magro, A. J. [UNESP], Iulek, J., Marchi-Salvador, D. P., Oliveira, C. Z., Salvador, G. H. M., Magro, A. J., Fontes, M. R. M., Correa, L. C., Marchi-Salvador, D. P. [UNESP], Correa, L. C. [UNESP], Salvador, G. H. M. [UNESP], Fontes, M. R. M. [UNESP], Soares, A. M.   +12 more
core   +1 more source

Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study

Toxins, 2018
The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological
Juan Carlos Quintana-Castillo, Leidy Johana Vargas, Cesar Segura, Sebastián Estrada-Gómez, Julio César Bueno-Sánchez, Juan Carlos Alarcón   +5 more
doaj   +1 more source

Crystallization and preliminary X-ray diffraction analysis of crotoxin B from Crotalus durissus collilineatus venom [PDF]

, 2009
Crotoxin B is a basic phospholipase A(2) found in the venom of several Crotalus durissus ssp. rattlesnakes and is one of the subunits that constitute crotoxin, the main component of the venom of these snakes.
Fernandes, C. A. H., Salvador, G. H. M., Salvador, G. H. M. [UNESP], Correa, L. C. [UNESP], Fontes, M. R. M., Fernandes, C. A. H. [UNESP], Fontes, M. R. M. [UNESP], Correa, L. C., Santos-Filho, N. A., Soares, A. M.   +9 more
core   +1 more source

Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study

Contemporary Clinical Trials Communications, 2017
Introduction: Crotoxin has a broad antitumor activity but has shown frequent neurotoxic toxicity. To induce tolerance and limit this toxicity, we propose a new design with intra-patient dose escalation.
Jacques Medioni, Mara Brizard, Reza Elaidi, Paul F. Reid, Khadija Benlhassan, Dorothy Bray   +5 more
doaj   +1 more source