Results 51 to 60 of about 1,216 (181)

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a ...
Leonardo A. Calderon, Juliana C. Sobrinho, Kayena D. Zaqueo, Andrea A. de Moura, Amy N. Grabner, Maurício V. Mazzi, Silvana Marcussi, Auro Nomizo, Carla F. C. Fernandes, Juliana P. Zuliani, Bruna M. A. Carvalho, Saulo L. da Silva, Rodrigo G. Stábeli, Andreimar M. Soares, Fernando Albericio   +14 more
wiley   +1 more source

Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin.
Laudicéia Alves de Oliveira, Rui Seabra Ferreira, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari dos Santos, Daniel Carvalho Pimenta   +6 more
doaj   +1 more source

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago, Edgar Alejandro Pinos Tamayo, Daniel Moreira dos Santos, Bonglee Kim, José R. Almeida, Rosy Iara Maciel de Azambuja Ribeiro, Marco Eigenfeld   +6 more
wiley   +1 more source

An Evaluation of 3‐Rhamnosylquercetin, a Glycosylated Form of Quercetin, against the Myotoxic and Edematogenic Effects of sPLA2 from Crotalus durissus terrificus

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
This paper shows the results of quercitrin effects on the structure and biological activity of secretory phospholipase (sPLA2) from Crotalus durissus terrificus, which is the main toxin involved in the pharmacological effects of this snake venom. According to our mass spectrometry and circular dichroism results, quercetin was able to promote a chemical
Daniela de Oliveira Toyama, Henrique Hessel Gaeta, Marcus Vinícius Terashima de Pinho, Marcelo José Pena Ferreira, Paulete Romoff, Fábio Filippi Matioli, Angelo José Magro, Marcos Roberto de Mattos Fontes, Marcos Hikari Toyama, Kota V. Ramana   +9 more
wiley   +1 more source

Anti-sera raised in rabbits against crotoxin and phospholipase A(2) from Crotalus durissus cascavella venom neutralize the neurotoxicity of the venom and crotoxin

, 2015
Crotoxin, the principal neurotoxin in venom of the South American rattlesnakes Crotalus durissus terrificus and Crotalus durissus cascavella, contains a basic phospholipase A(2) (PLA(2)) and an acidic protein, crotapotin.
Hyslop, Stephen, Hernandez-Oliveira, S, Hyslop, S, Marangoni, Sérgio, Beghini, DG, Marangoni, S, Hernandez-Oliveira, Saraguaci, Novello, José Camilo, Rodrigues-Simioni, L, Novello, JC, Beghini, Daniela G, Rodrigues-Simioni, Léa   +11 more
core   +2 more sources

Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae)

International Scholarly Research Notices, Volume 2014, Issue 1, 2014., 2014
Eclipta alba can be found growing wild in fallow lands of Bangladesh where it is considered as a weed by farmers. Traditional medicinal systems of the Indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract ...
Rownak Jahan, Abdullah Al-Nahain, Snehali Majumder, Mohammed Rahmatullah, Jagadananda Ghosh   +4 more
wiley   +1 more source

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
In this study, we evaluated the actions of Crotalus durissus cumanensis venom (CDCmV), and its crotoxin (Crtx) fraction, on renal and vascular functions in Wistar rats.
TP Pereira, RRPP Bezerra de Menezes, AFC Torres, TS Brito, FJ Batista-Lima, JFC Vinhote, DF Sousa, RM Ximenes, MH Toyama, EBS Diz Filho, PJC Magalhães, HSA Monteiro, AMC Martins   +12 more
doaj   +1 more source

Prey specificity of predatory venoms

Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.
ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek, Glenn F. King, Stano Pekár   +2 more
wiley   +1 more source

Crotalus durissus collilineatus Venom Induces TNF‐α and IL‐10 Production in Human Peripheral Blood Mononuclear Cells

International Scholarly Research Notices, Volume 2014, Issue 1, 2014., 2014
Snake venom has been the subject of numerous studies in an attempt to find properties and biological effects that may be beneficial to man. In this study we evaluated in vitro the effects of Crotalus durissus terrificus (Cdt) and Crotalus durissus collilineatus (Cdc) venom in human peripheral blood mononuclear cells (PBMCs).
Camila Bastos Ribeiro, Jéssica Cristina dos Santos, Jacyelle Medeiros Silva, Pedro Henrique Silva de Godoi, Marta Regina Magalhães, Mônica Spadafora-Ferreira, Simone Gonçalves Fonseca, Irmtraut Araci Hoffman Pfrimer, A. El-Shazly, U. Musabak, T. Oshima, T. Pessi   +11 more
wiley   +1 more source

Snake venom toxins: Potential anticancer therapeutics

Journal of Applied Toxicology, Volume 44, Issue 5, Page 666-685, May 2024.
Abstract Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment
Benedict C. Offor, Lizelle A. Piater
wiley   +1 more source