Results 31 to 40 of about 686 (159)

Detection and quantification of a β-neurotoxin (crotoxin homologs) in the venom of the rattlesnakes Crotalus simus, C. culminatus and C. tzabcan from Mexico

Toxicon: X, 2019
Snake venom may vary in composition and toxicity across the geographic distribution of a species. In the case of the three species of the Neotropical rattlesnakes Crotalus simus, C. culminatus and C. tzabcan recent research has revealed that their venoms
Edgar Neri-Castro, Arely Hernández-Dávila, Alejandro Olvera-Rodríguez, Héctor Cardoso-Torres, Melisa Bénard-Valle, Elizabeth Bastiaans, Oswaldo López-Gutierrez, Alejandro Alagón   +7 more
doaj   +1 more source

Actions of Crotalus durissus terrificus venom and crotoxin on the isolated rat kidney

Brazilian Journal of Medical and Biological Research, 2001
Many studies have reported the occurrence of lethal acute renal failure after snakebites. The aim of the present investigation was to determine alterations in renal function produced by Crotalus durissus terrificus venom and crotoxin as well as the ...
H.S.A. Monteiro, I.M.S.C. da Silva, A.M.C. Martins, M.C. Fonteles   +3 more
doaj   +1 more source

Crotoxin, the major toxin from the rattlesnake Crotalus durissus terrificus, inhibits ³H-choline uptake in guinea pig ileum

Brazilian Journal of Medical and Biological Research, 2000
We examined the effect of crotoxin, the neurotoxic complex from the venom of the South American rattlesnake Crotalus durissus terrificus, on the uptake of ³H-choline in minces of smooth muscle myenteric plexus from guinea pig ileum.
L.S. Kattah, M.M. Santoro, C.R. Diniz, M.E. De Lima   +3 more
doaj   +1 more source

Biological Roles of the Two Components of Crotoxin [PDF]

Proceedings of the National Academy of Sciences, 1971
Crotoxin, the Brazilian rattlesnake neurotoxin, generally behaves as a homogeneous protein; however, it is a molecular complex of an acidic and a basic protein. These can be separated after alkylation or acylation of the amino groups, or on carboxymethyl cellulose at pH 4, or on DEAE-cellulose in 6 M urea. The two proteins differ greatly in composition,
R A, Hendon, H, Fraenkel-Conrat
openaire   +2 more sources

Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus.
Marco Aurélio Sartim, Danilo Luccas Menaldo, Suely Vilela Sampaio   +2 more
doaj   +1 more source

Crystal Structure of Isoform CBd of the Basic Phospholipase A₂ Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets

Molecules, 2020
Crotoxin, from the venom of the South American rattlesnake Crotalus durissus terrificus, is a potent heterodimeric presynaptic β-neurotoxin that exists in individual snake venom as a mixture of isoforms of a basic phospholipase A2 (PLA2) subunit (CBa2 ...
Dorota Nemecz, Maciej Ostrowski, Marc Ravatin, Frederick Saul, Grazyna Faure   +4 more
doaj   +1 more source

Clinical, Laboratory, and Therapeutic Aspects of Crotalus durissus (South American Rattlesnake) Victims: A Literature Review

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Snakebite envenoming is a neglected public health issue in many tropical and subtropical countries. To diagnosis and treat snakebites may be challenging to health care personnel since sufficient information has not been yet provided. This review presents the clinical, therapeutic, and laboratory aspects of Crotalus durissus (South American rattlesnakes)
Bruno Tumang Frare, Yann Keller Silva Resende, Bruno de Carvalho Dornelas, Miguel Tannus Jorge, Valter Augusto Souza Ricarte, Lívia Maria Alves, Luiz Fernando Moreira Izidoro, Giuseppe Piccione   +7 more
wiley   +1 more source

Crotalus durissus terrificus venom as a source of antitumoral agents

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase ...
MA Soares, PB Pujatti, CL Fortes-Dias, L Antonelli, RG Santos   +4 more
doaj   +1 more source

Crotalus durissus ruruima Snake Venom and a Phospholipase A2 Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Viper snake Crotalus durissus ruruima (Cdr) is a subspecies found in northern area of Brazil. Among the snakes of Crotalus genus subspecies, the venom of Cdr presents highest level of crotoxin, which is the major component of Crotalus snake venoms, formed by two subunits (crotapotin and a phospholipase A2 named CBr) and presents potent neurotoxic ...
Ana Eduarda Zulim de Carvalho, Karina Giannotti, Elbio Leiguez Junior, Márcio Matsubara, Maria Cristina Dos Santos, Consuelo Latorre Fortes-Dias, Catarina Teixeira, Benoit Stijlemans   +7 more
wiley   +1 more source

Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Natural products with antispasmodic activity have been used in traditional medicine to alleviate different illnesses since the remote past. We searched the literature and compiled the antispasmodic activity of 248 natural compounds isolated from terrestrial plants.
Edith Fabiola Martínez-Pérez, Zaida N. Juárez, Luis R. Hernández, Horacio Bach, Juergen Buenger   +4 more
wiley   +1 more source