Results 91 to 100 of about 1,959 (214)

Comparison of crotoxin isoforms reveals that stability of the complex plays a major role in its pharmacological action

, 1993
Crotoxin from the venom of the South American rattlesnake Crotalus durissus terrificus is a potent neurotoxin consisting of a weakly toxic phospholipase-A2 subunit (CB) and a non-enzymic, non-toxic subunit (CA).
Bon, C, Radvanyi, F, Faure, G, Saliou, B, Harvey, A L, Thomson, E   +5 more
core   +3 more sources

Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study

Contemporary Clinical Trials Communications, 2017
Introduction: Crotoxin has a broad antitumor activity but has shown frequent neurotoxic toxicity. To induce tolerance and limit this toxicity, we propose a new design with intra-patient dose escalation.
Jacques Medioni, Mara Brizard, Reza Elaidi, Paul F. Reid, Khadija Benlhassan, Dorothy Bray   +5 more
doaj   +1 more source

Biological And Structural Characterization Of Crotoxin And New Isoform Of Crotoxin B Pla2 (f6a) From Crotalus Durissus Collilineatus Snake Venom [PDF]

, 2006
A new crotoxin B isoform PLA(2) (F6a), from Crotalus durissus collilineatus was purified from by one step reverse phase HPLC chromatography using mu-Bondapack C-18 column analytic.
Ponce-Soto, LA, Marangoni, Sergio, Rodrigues Simioni, Lea, Marangoni, S, Ponce Soto, Luis Alberto, Lomonte, B, Rodrigues-Simioni, L, Ponce-Soto, Luis Alberto, Rodrigues-Simioni, Lea, Novello, JC, Lomonte, Bruno, Novello, José Camillo, Lomonte B., Novello J.C., Rodrigues-Simioni L., Ponce-Soto L.A., Marangoni S.   +16 more
core   +1 more source

Crotoxin-induced behavioral effects in rats

, 2014
Crotoxin is the major component of Crotalus durissus terrificus venom. In view of the presence of high-affinity specific binding sites for crotoxin in the brain, the objective of this work was to investigate whether crotoxin induces behavioral effects in
Moreira, E. G., Rosa, GJM, Vassilieff, V. S., Rogero, JR, Nascimento, N.   +4 more
core  

Single-step purification of crotapotin and crotactine from Crotalus durissus terrificus venom using preparative isoelectric focusing

Brazilian Journal of Medical and Biological Research, 1997
We describe the isolation of crotoxin, a presynaptic B-neurotoxin, as well as its subunits B (crotactine) and A (crotapotin) from lyophilized Crotalus durissus terrificus venom by a single-step preparative isoelectric focusing procedure.
A.S. Aguiar, A.R. Melgarejo, C.R. Alves, S. Giovanni-De-Simone   +3 more
doaj   +1 more source

Nature Of The Postsynaptic Action Of Crotoxin At Guinea-pig Diaphragm End-plates.

, 2015
Crotoxin is known to desensitize the nicotinic receptor of Torpedo marmorata and Electrophorus electricus electroplaques. The aim of the present study was to elucidate whether the postsynaptic effect of crotoxin at a mammalian muscle end-plate is also ...
Heluany, N F, Fontana, M D, Brazil, O V
core   +1 more source

Systemic and local myotoxicity induced by snake venom group II phospholipases A(2): Comparison between crotoxin, crotoxin B and a Lys49 PLA(2) homologue

, 2008
The patterns of myotoxicity induced in mice by crotoxin, crotoxin B and a Lys49 phospholipase A(2)(PLA(2)) homologue were compared. Lys49 PLA(2)-induced local myotoxicity is reflected by creatine kinase (CK) loss in injected gastrocnemius muscle, and by ...
Ponce-Soto, LA, Marangoni, Sergio, Marangoni, S, Ponce Soto, Luis Alberto, Gutierrez, JM, Lomonte, B, Lomonte, Bruno, Gutiérrez, José María   +7 more
core   +1 more source

Identification, description and structural analysis of beta phospholipase A2 inhibitors (sbβPLIs) from Latin American pit vipers indicate a binding site region for basic snake venom phospholipases A2

Toxicon: X, 2019
Several snake species possess, in their circulating blood, endogenous PLA2 inhibitors (sbPLIs) with the primary function of natural protection against toxic enzymes from homologous and heterologous venoms.
Consuelo Latorre Fortes-Dias, Carlos Alexandre H. Fernandes, Paula Ladeira Ortolani, Patrícia Cota Campos, L.A. Melo, Liza Figueiredo Felicori, Marcos Roberto M. Fontes   +6 more
doaj   +1 more source

Crotoxin promotes macrophage reprogramming towards an antiangiogenic phenotype

Scientific Reports, 2019
Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. CTX reduces tumour mass, and tumour cell proliferation and these effects seem to involve the formation of new vessels.
Luciana de Araújo Pimenta, M. E. S. de Almeida, Marisa Langeani Bretones, M. Cirillo, R. Curi, S. C. Sampaio   +5 more
semanticscholar   +1 more source

First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis

, 2015
artículo -- Universidad de Costa Rica, Instituto de Investigaciones Clodomiro Picado, 2015. Investigación apoyada por ICGEB-Italia, CYTED, Ministerio de Economía y Competitividad de España.
Sanz, Libia, Fernández Ulate, Julián, Pla Ferrer, Davinia, Lomonte, Bruno, Mora Obando, Diana, Gutiérrez, José María, Calvete Chornet, Juan José   +6 more
core   +1 more source