Results 101 to 110 of about 1,959 (214)

Conformation of the neurotoxin crotoxin complex and its subunits

Biochemistry, 1979
Crotoxin, the neurotoxin from Crotalus durissus terrificus venom, and its two subunits, crotoxin A and crotoxin B, have been examined by fluorescence and circular dichroism techniques. Model spectra of crotoxin, generated from the expected contributions of the individual subunits, agreed with experimental results only at pH 2, where crotoxin was fully ...
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The molecular weight of crotoxin [PDF]

Biochemical Journal, 1938
N, Gralén, T, Svedberg
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Crotoxin-induced behavioral effects in rats.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 1997
Crotoxin is the major component of Crotalus durissus terrificus venom. In view of the presence of high-affinity specific binding sites for crotoxin in the brain, the objective of this work was to investigate whether crotoxin induces behavioral effects in the open-field and hole-board tests. Adult male Wistar rats (180-220 g) treated with crotoxin, 100,
Moreira, E. G., Nascimento, N., Rosa, G. J.M., Rogero, J. R., Vassilieff, V. S.   +4 more
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Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom

, 2006
In this article we investigated the platelet aggregating activity of whole crotoxin and its subunits isolated from Crotalus durissus cascavella venom.
Antunes, E., Fonseca, F. V., Morganti, R. P., Marangoni, S., Martins, A. M. C., Toyama, M. H., Toyama, D. O., Monteiro, Helena S. A., Toyama, M.H., Martins, A.M.C., Fonseca, F.V., Morganti, R.P., Monteiro, H.S.A., Toyama, D.O.   +13 more
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Neutralizing Human Anti Crotoxin scFv Isolated from a Nonimmunized Phage Library

, 2000
International audienceCombinatorial phage display technology offers a new possibility for making human antibodies which could be used in immune therapy.
Nato, F., Lafaye, Pierre, Vaughan, T., J., Mota, I., Choumet, V., Mazie, J., C., England, Patrick, Cardoso, D., F., Ferreira, M., L.   +8 more
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Crotoxin alters lymphocyte distribution in rats: Involvement of adhesion molecules and lipoxygenase-derived mediators

, 2008
Crotoxin is the main neurotoxic component of Crotalus durissus terrificus snake venom and modulates immune and inflammatory responses, interfering with the activity of leukocytes.
SUDO-HAYASHI, Lia S., OTTON, Rosemari, Curi, Rui, Vanessa O. Zambelli, Yara Cury, SAMPAIO, Sandra C., Luis R.C. Gonçalves, Maisa S. Della-Casa, CURY, Yara, Adilson S. Alves, Luiz R.G. Britto, ZAMBELLI, Vanessa O., BRITTO, Luiz R. G., ZYCHAR, Bianca C., Sandra C. Sampaio, Karin Greco, Diva D. Spadacci-Morena, Rui Curi, DELLA-CASA, Maisa S., ALVES, Adilson S., Lia S. Sudo-Hayashi, GRECO, Karin, SPADACCI-MORENA, Diva D., Bianca C. Zychar, GONCALVES, Luis R. C., Rosemari Otton   +25 more
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Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Cratalus durissus terrificus venom

, 2008
Crotoxin B (CB or Cdt PLA(2)) is a basic Asp49-PLA(2) found in the venom of Crotalus durissus terrificus and it is one of the subunits that constitute the crotoxin (Cro). This heterodimeric toxin, main component of the C. d.
Oliveira, Clayton Z., Magro, Angelo J. [UNESP], Fontes, Marcos R. M., Correa, Luiz C., Marchi-Salvador, Daniela P., Soares, Andreimar M., Correa, Luiz C. [UNESP], Marchi-Salvador, Daniela P. [UNESP], Fontes, Marcos R. M. [UNESP], Magro, Angelo J.   +9 more
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OBTAINMENT OF CROTOXIN/PHEMA-G-LDPE AND CROTOXIN/PCL SYSTEMS

, 2006
A finalidade deste trabalho de pesquisa foi a obtenção de matrizes poliméricas imobilizadas com a crotoxina, proveniente do veneno bruto de cascavel.
Solange Gubbelini Lorenzetti, Lorenzetti, Solange Gubbelini   +1 more
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Neutralizing Capacity Of Antisera Raised In Horses And Rabbits Against Crotalus Durissus Terrificus (south American Rattlesnake) Venom And Its Main Toxin, Crotoxin.

, 2015
Crotalus durissus terrificus (South American rattlesnake) venom possesses myotoxic and neurotoxic activities, both of which are also expressed by crotoxin, the principal toxin of this venom. We have investigated the ability of commercial equine antivenom
Hyslop, S, Prado-Franceschi, J, Rodrigues-Simioni, L, Cruz-Höfling, M A, Oshima-Franco, Y   +4 more
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Modes of action of crotoxin and of its binding protein crocalbin

, 2010
蛇類經過長年的演化後，有許多的蛇毒蛋白質分子都具有藥效，南美響尾蛇蛇毒的主要成分crotoxin具有強烈的神經毒性，會阻斷周邊運動神經的訊息傳導分子的釋放，造成獵物四肢麻痺、窒息而死亡。Crotoxin乃是由crotoxin A（CA）及crotoxin B（CB）兩個次單元體以非共價鍵所組合而成，CA不帶有生物活性卻能使CB的毒性增加數十倍，所以一般認為CA是要彌補CB缺陷的chaperon。於crotoxin的研究從30年代就已經開始，但至今對分子層級的作用機制並不清楚。實驗顯示CA會出現在溶液相中，
李一良, Lee, I-Liang
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