Results 81 to 90 of about 1,959 (214)

A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities

Revista do Instituto de Medicina Tropical de São Paulo, 1992
A mionecrose é um dos efeitos causados pelo veneno de Bothrops jararacussu. Uma miotoxina com homologia estrutural à fosfolipase A2 (PLA2), mas sem atividade enzimática, foi isolada desse veneno.
Maria Cristina dos-Santos, Luís Roberto de Camargo Gonçalves, Consuelo L. Fortes-Dias, Yara Cury, José Maria Gutiérrez, Maria de Fátima D. Furtado   +5 more
doaj   +1 more source

Correlating biological activity to thermo-structural analysis of the interaction of CTX with synthetic models of macrophage membranes

Scientific Reports, 2021
The important pharmacological actions of Crotoxin (CTX) on macrophages, the main toxin in the venom of Crotalus durissus terrificus, and its important participation in the control of different pathophysiological processes, have been demonstrated.
Luciana de Araújo Pimenta, Evandro L. Duarte, Gabriel S. Vignoli Muniz, Kerly Fernanda Mesquita Pasqualoto, Marcos Roberto de Mattos Fontes, M. Teresa Lamy, Sandra Coccuzzo Sampaio   +6 more
doaj   +1 more source

Role of crotoxin in coagulation: novel insights into anticoagulant mechanisms and impairment of inflammation-induced coagulation

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Snake venom phospholipases A2 (svPLA2) are biologically active toxins, capable of triggering and modulating a wide range of biological functions.
Bruna Terada Gimenez, G. Cezarette, Aline de Sousa Bomfim, W. Monteiro, Elisa Maria de Sousa Russo, F. Frantz, S. Sampaio, M. Sartim   +7 more
semanticscholar   +1 more source

Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions

Mediators of Inflammation, 2001
Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2.
Diva F. Cardoso, Monica Lopes-Ferreira, Eliana L. Faquim-Mauro, Mahasti S. Macedo, Sandra H. P. Farsky   +4 more
doaj   +1 more source

Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper ...
Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto   +7 more
doaj   +1 more source

Evaluation of the Effectiveness of Crotoxin as an Antiseptic against Candida spp. Biofilms

Toxins, 2020
The growing number of oral infections caused by the Candida species are becoming harder to treat as the commonly used antibiotics become less effective. This drawback has led to the search for alternative strategies of treatment, which include the use of
A. Canelli, Taís Fernanda Dos Santos Rodrigues, V. F. F. de Góes, G. Caetano, M. V. Mazzi   +4 more
semanticscholar   +1 more source

Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis

, 2015
A myographic study was performed to compare the neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis in mice phrenic-diaphragm preparation.
Garrido Cavalcante, Walter Luis, Garrido Cavalcante, Walter Luis [UNESP], Marangoni, Sergio, Gallacci, Marcia [UNESP], Cavalcante, Walter Luís Garrido, Ponce-Soto, Luis Alberto, Gallacci, Márcia   +6 more
core   +1 more source

Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study

Toxins, 2018
The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological
Juan Carlos Quintana-Castillo, Leidy Johana Vargas, Cesar Segura, Sebastián Estrada-Gómez, Julio César Bueno-Sánchez, Juan Carlos Alarcón   +5 more
doaj   +1 more source

Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG35-55-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.

Brain, behavior, and immunity, 2019
Multiple sclerosis (MS) is a Central Nervous System inflammatory demyelinating disease that has as primary symptoms losses of sensory and motor functions, including chronic pain.
N. B. Teixeira, M. B. Sant'Anna, A. C. Giardini, Leandro Pires Araujo, L. A. Fonseca, Alexandre S. Basso, Y. Cury, G. Picolo   +7 more
semanticscholar   +1 more source

Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin.

Journal of Proteomics, 2019
Venoms of the three species of Ophryacus (O. sphenophrys, O. smaragdinus, and O. undulatus), a viperid genus endemic to Mexico, were analyzed for the first time in the present work.
E. Neri-Castro, B. Lomonte, M. Valdés, Roberto Ponce-Lopez, Melisa Bénard-Valle, Miguel Borja, Jason L. Strickland, Jason M. Jones, Christoph I. Grünwald, F. Zamudio, A. Alagón   +10 more
semanticscholar   +1 more source