Results 41 to 50 of about 12,518 (182)

Real-Time Acute Kidney Injury Risk Stratification–Biomarker Directed Fluid Management Improves Outcomes in Critically Ill Children and Young Adults

Kidney International Reports, 2023
Introduction: Critically ill admitted patients are at high risk of acute kidney injury (AKI). The renal angina index (RAI) and urinary biomarker neutrophil gelatinase-associated lipocalin (uNGAL) can aid in AKI risk assessment.
Stuart L. Goldstein, Kelli A. Krallman, Jean-Philippe Roy, Michaela Collins, Ranjit S. Chima, Rajit K. Basu, Lakhmir Chawla, Lin Fei   +7 more
doaj   +1 more source

Drug Removal by CRRT and Drug Dosing in Patients on CRRT

, 2015
Correct drug dosing is of utmost importance for therapeutic success in critically ill patients. This especially applies to sepsis where early adequate dosing of antibiotics may be lifesaving. Correct drug dosing should take into account the major alterations in pharmacokinetics induced by critical illness and the drug’s pharmacokinetic/pharmacodynamic ...
Schetz, Miet, Joannes-Boyau, Olivier, Bouman, Catherine   +2 more
openaire   +1 more source

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source

CRRTnet: a prospective, multi-national, observational study of continuous renal replacement therapy practices

BMC Nephrology, 2017
Background Continuous renal replacement therapy (CRRT) is the recommended modality of dialysis for critically ill patients with hemodynamic instability.
Michael Heung, Sean M. Bagshaw, Andrew A. House, Luis A. Juncos, Robin Piazza, Stuart L. Goldstein   +5 more
doaj   +1 more source

Population Pharmacokinetics of Ticagrelor during Veno‐Arterial ECMO in Acute Coronary Syndrome: Model‐Informed Dosing Simulations

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 193-202, July 2026.
Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang, Kyoung Lok Min, Seungwon Yang, Jongsung Hahn, Dasohm Kim, Byung Hak Jin, Soon Uk Chae, Soo Kyung Bae, Jin Wi, Min Jung Chang   +9 more
wiley   +1 more source

Change in platelet and leukocyte counts and hospital mortality in adults with acute kidney injury receiving continuous renal replacement therapy

Scientific Reports
Background Changes in platelet and white blood cell (WBC) counts during CRRT could identify patients at risk for adverse outcomes. We examined the association of change in platelet and WBC from pre-CRRT to during-CRRT with hospital mortality.
Lan N. Bui, Joshua W. Lambert, Chloe G. Braun, Lucas J. Liu, Augusto X. Cama-Olivares, Victor Ortiz-Soriano, Tomonori Takeuchi, Orson W. Moe, Robert D. Toto, Ashita J. Tolwani, Jin Chen, Kianoush Kashani, Javier A. Neyra   +12 more
doaj   +1 more source

Predicting restoration of kidney function during CRRT-free intervals

Journal of Cardiothoracic Surgery, 2012
Background Renal failure is common in critically ill patients and frequently requires continuous renal replacement therapy (CRRT). CRRT is discontinued at regular intervals for routine changes of the disposable equipment or for replacing clogged filter ...
Heise Daniel, Gries Daniel, Moerer Onnen, Bleckmann Annalen, Quintel Michael   +4 more
doaj   +1 more source

Polymyxin B Intravenous Administration Strategy Guided by Minimum Inhibitory Concentration in Critically Ill Patients With Pulmonary Infection: Insights From PBPK Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
PBPK/PD modeling and clinical retrospective validation of intravenous polymyxin B in critically ill patients with pulmonary infection. ABSTRACT Intravenous polymyxin B (PMB) is widely used for treating drug‐resistant gram‐negative pneumonia, though its efficacy in pulmonary infections is considered limited.
Shengnan Zhang, Nan Yang, Ruwei Yang, Yuanfang Qin, Tingting Wu, Cuifang Wu, Yueliang Xie, Jingjing Liu, Chun Liu, Qi Pei   +9 more
wiley   +1 more source

Effects of early and late continuous renal replacement therapy on intensive care unit mortality in patients with COVID-19 with acute respiratory distress syndrome and acute kidney injury: a comparative study

Renal Replacement Therapy
Introduction Acute kidney injury (AKI) is linked to disease severity and prognosis in patients with coronavirus disease 2019 (COVID-19), and mortality increases even with milder stages.
Verda Tuna, Emre Senturk, Gunseli Orhun, Ozlem Polat, Ilkay Anakli, Gulcin Alay, Emre Celiksoy, Mehmet Kilic, Mercan Mutlu, Esen Figen, Perihan Ergin Ozcan   +10 more
doaj   +1 more source

Anidulafungin dosing during CRRT: do not underestimate adsorption! [PDF]

Critical Care, 2014
Two recent papers in Critical Care discuss the use of echinocandins in general [1], and anidulafungin in particular [2], during continuous renal replacement therapy (CRRT). Being highly protein bound and predominantly nonrenally eliminated drugs, echinocandins are barely removed by convection and thus require no dose adjustment during CRRT. Based on
Honoré, Patrick M, Jacobs, Rita, De Waele, Elisabeth, Spapen, Herbert D   +3 more
openaire   +3 more sources