Results 41 to 50 of about 214,613 (295)

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Strategy for controlling tourist mobility: analysis of the biopolitical processes of territorialization implemented by the cruise tourism industry in a Caribbean destination

Via@, 2022
The deployment of cruise tourism in a destination leads to the production of a space of cruise tourism through a process involving the reterritorialization of everyday spaces.
Luc Renaud
doaj   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Precise Cruise Control for Fixed-Wing Aircraft Based on Proximal Policy Optimization with Nonlinear Attitude Constraints

Aerospace
In response to the issues of severe pitch oscillation and unstable roll attitude present in existing reinforcement learning-based aircraft cruise control methods during dynamic maneuvers, this paper proposes a precise control method for aircraft cruising
Haotian Wu, Yan Guo, Juliang Cao, Zhiming Xiong, Junda Chen   +4 more
doaj   +1 more source

Efficient predictive cruise control of autonomous vehicles with improving ride comfort and safety

Measurement + Control, 2020
In this paper, the adaptive cruise control problem of autonomous vehicles is considered and we propose a novel predictive cruise control approach to improve driving safety and comfort of the host vehicle.
Defeng He, Wentao He, Xiulan Song
doaj   +1 more source

Evaluating air emission inventories and indicators from cruise vessels at ports [PDF]

, 2017
This paper provides an estimation of air emissions (CO2, NOX, SOX and PM) released by cruise vessels at the port level. The methodology is based on the Bfull bottom-up^ approach and starts by evaluating the fuel consumed by each vessel on the basis of
Martín Alcalde, Enrique, Melo Rodríguez, Germán de, Murcia González, Juan Carlos, Saurí Marchán, Sergi   +3 more
core   +2 more sources

Aircraft Rescheduling with Cruise Speed Control [PDF]

Operations Research, 2014
Airline operations are subject to frequent disruptions typically due to unexpected aircraft maintenance requirements and undesirable weather conditions. Recovery from a disruption often involves propagating delays in downstream flights and increasing cruise stage speed when possible in an effort to contain the delays.
Aktürk, M.S., Atamtürk, A., Gürel, S.
openaire   +6 more sources

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Analyzing Attacks on Cooperative Adaptive Cruise Control (CACC)

, 2017
Cooperative Adaptive Cruise Control (CACC) is one of the driving applications of vehicular ad-hoc networks (VANETs) and promises to bring more efficient and faster transportation through cooperative behavior between vehicles.
Kargl, Frank, Lukaseder, Thomas, van der Heijden, Rens Wouter   +2 more
core   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source