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CRTH2 Plays an Essential Role in the Pathophysiology of Cry j 1-Induced Pollinosis in Mice

CRTH2 Plays an Essential Role in the Pathophysiology of Cry j 1-Induced Pollinosis in Mice
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Reduced anaphylactic potential of denatured pullulan-conjugated Cry j 1

International Immunopharmacology, 2021
Japanese Cedar (JC) pollinosis is the most common seasonal allergic rhinitis in Japan. Throughout the JC pollen season, patients suffer from the allergic symptoms, resulting in a reduction of quality of life. Allergy immunotherapy (AIT) is an established treatment option for a wide range of allergens that unlike symptomatic treatments (e.g ...
Daichi, Utsumi, Takeru, Sugawara, Kosumo, Hashida, Yuki, Yasuhara, Koji, Fujinami, Kaare, Lund, Katsuyo, Ohashi-Doi   +6 more
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Th1/Th2 response profiles to the major allergens Cry j 1 and Cry j 2 of Japanese cedar pollen

Allergy, 1996
Cry j 1 and Cry j 2 are known to be the major allergens of Japanese cedar pollen. A comparative study was carried out on the immune responses to stimulation with Cry j 1 and Cry j 2 in 24 symptomatic patients and six nonallergic subjects. In T‐cell proliferation assays, mean stimulation indexes (SI) were 10.6 for Cry j 1 and 11.7 for Cry j 2 ...
K, Sugimura, S, Hashiguchi, Y, Takahashi, K, Hino, Y, Taniguchi, M, Kurimoto, K, Fukuda, M, Ohyama, G, Yamada   +8 more
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Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide

Comparative Immunology, Microbiology and Infectious Diseases, 2011
We determined whether a major Japanese cedar pollen allergen (Cry j 1) conjugated with CpG oligodeoxynucleotide would enhance allergen-specific Th1 responses in mice. Cry j 1 conjugated with CpG (Cry j 1-CpG) induced IL-12 in the spleen cells of naïve mice.
Y, Kaburaki, T, Fujimura, K, Kurata, K, Masuda, M, Toda, H, Yasueda, K, Chida, S, Kawarai, M, Sakaguchi   +8 more
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Comparison of concentrations of Cry j 1 and Cry j 2 in diploid and triploid Japanese cedar (Cryptomeria japonica) pollen extracts

Allergy, 1997
Japanese cedar (Cryptomeria japonica) pollinosis has been a serious allergic disease in Japan. There are two kinds of Japanese cedar trees; the popular one is diploid, the less popular is triploid. These trees are not very different morphologically. However, the relative allergenicity of their pollens is unknown, although both major allergens, Cry j 1 ...
Y, Kondo, H, Ipsen, H, Løwenstein, A, Karpas, L S, Hsieh   +4 more
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IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis

Veterinary Immunology and Immunopathology, 2000
The present study investigated IgE-reactivity to two major Japanese cedar (Cryptomeria japonica, C. japonica) pollen allergens (Cry j 1 and Cry j 2) in dogs with atopic dermatitis by use of a fluorometric ELISA. The serum samples from 27 dogs that showed IgE-sensitivity to crude C.
K, Masuda, H, Tsujimoto, S, Fujiwara, K, Kurata, A, Hasegawa, Y, Taniguchi, K, Yamashita, H, Yasueda, D J, DeBoer, A L, de Weck, M, Sakaguchi   +10 more
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Preclinical evaluation of an immunotherapeutic peptide comprising 7 T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens

Journal of Allergy and Clinical Immunology, 2001
Peptide immunotherapy is a new approach to treating allergic diseases, but a therapeutic peptide for Japanese cedar pollinosis has not yet been developed.The aim of this study is to prepare and preclinically evaluate a hybrid peptide comprising 7 T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens.The recombinant ...
K, Hirahara, T, Tatsuta, T, Takatori, M, Ohtsuki, H, Kirinaka, J, Kawaguchi, N, Serizawa, Y, Taniguchi, S, Saito, M, Sakaguchi, S, Inouye, A, Shiraishi   +11 more
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Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice

International Immunopharmacology, 2010
Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen (Cry j 1/OMLs), in Balb/c mice ...
Naoya Kojima, Hideki Narumi
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Reduction of Antigenicity of Cry j 1, a Major Allergen of Japanese Cedar Pollen, by Thermal Denaturation

Journal of Agricultural and Food Chemistry, 2009
The soluble aggregates of Cry j 1, a major allergen of Japanese cedar pollen, were formed without any coagulates during heat treatment at acidic pH 5, as shown in HPLC and SDS-PAGE patterns. A remarkable change in the CD spectrum was observed between native and heat-denatured Cry j 1 at a linear rate of 1 degrees C/min from 40 to 90 degrees C.
Rieko, Aoki, Akira, Saito, Masakatsu, Usui, Hiroyuki, Azakami, Akio, Kato   +4 more
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Roles of major oligosaccharides on Cry j 1 in human immunoglobulin E and T cell responses

Clinical & Experimental Allergy, 2004
SummaryBackground We have demonstrated that carbohydrates in Cry j 1, the major allergen of Cryptomeria japonica pollen, play a major role in promoting Cry j 1‐specific Th2 response. However, little is known as to whether the carbohydrates directly participate in allergic responses.Objective We sought to determine whether Cry j 1‐related ...
M, Okano, Y, Kimura, K, Kino, Y, Michigami, S, Sakamoto, Y, Sugata, M, Maeda, F, Matsuda, M, Kimura, T, Ogawa, K, Nishizaki   +10 more
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