Results 261 to 270 of about 542,780 (295)

[Development of super-sensitive radical immunoassay for Cry j 1].

Arerugi = [Allergy], 2005
We have been developed super-sensitive method of Cry j 1 measurement by ESR radical immunoassay using p-acetamidophenol and hydroxylamine system. The detection limit for Cry j 1 was 3.5 pg/ml. It is reported that the average content of Cry j 1 in each Cryptomeria japonica pollen is about 6 pg, therefore, we can detect one grain or even less one grain ...
Masaaki, Aoyama, Yuichi, Takahashi
openaire   +1 more source

Peptide Specificity, HLA Class II Restriction, and T–Cell Subsets of the T–Cell Clones Specific to Either Cry j 1 or Cry j 2, the Major Allergens of Japanese Cedar (Cryptomeria japonica) Pollen

International Archives of Allergy and Immunology, 1999
<b>Background:</b> Cry j 1 and Cry j 2 are thought to be the major allergens of Japanese cedar pollen. HLA class II types capable of presenting T–cell epitopes in both allergens and their role in induction of T–cell subsets are not well known.
T, Sone, K, Morikubo, K, Shimizu, N, Komiyama, H, Tsunoo, K, Kino   +5 more
openaire   +2 more sources

Pollen-Specific Expression of the Gene for an Allergen, Cry j 1, in Cryptomeria japonica

Journal of Forest Research, 1998
A cDNA fragment for an allergen, Cry j 1 in sugi (Cryptomeria japonica D. Don) was generated by the reverse transcriptase-polymerase chain reaction. Using this cDNA fragment, we determined the number of copies of theCry j 1 gene in the sugi genome and the organ-specific expression of theCry j 1 gene in sugi trees.
Yunqiu Wang, Yuzuru Mukai, Mitsue Fukui, Norihiro Futamura, Akinori Nagao, Kenji Shinohara   +5 more
openaire   +1 more source

Roles of carbohydrates on Cry j 1, the major allergen of Japanese cedar pollen, in specific T-cell responses

Journal of Allergy and Clinical Immunology, 2001
Carbohydrates expressed on allergens are known to be important for allergenicity. However, little is known about whether the carbohydrates drive the T(H)2 response.We sought to determine a role for carbohydrates expressed on Cry j 1, which is the major allergen of Cryptomeria japonica pollen and causes the most prevalent pollinosis in Japan, in in ...
M, Okano, K, Kino, T, Takishita, H, Hattori, T, Ogawa, T, Yoshino, M, Yokoyama, K, Nishizaki   +7 more
openaire   +2 more sources

Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice

International Immunopharmacology, 2010
Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen (Cry j 1/OMLs), in Balb/c mice ...
Mariko, Ishii, Aki, Koyama, Hiroshi, Iseki, Hideki, Narumi, Naoaki, Yokoyama, Naoya, Kojima   +5 more
openaire   +2 more sources

Identification of peptides containing T-cell epitopes of Japanese cedar (Cryptomeria japonica) pollen allergen (Cry j 1) in dogs

Veterinary Immunology and Immunopathology, 2004
Japanese cedar (Cryptomeria japonica, CJ) pollen has been known to cause atopic dermatitis in dogs in Japan. However, since the mechanism of the CJ antigen recognition is not well understood in dogs, it is difficult to develop effective immunotherapy for atopic dermatitis caused by sensitization to CJ pollen. In order to aim at development of a peptide
K, Masuda, M, Sakaguchi, S, Saito, H, Yasueda, S, Iwabuchi, T, Tsukui, N, Hayashi, Y, Nakao, K, Kurata, S, Maeda, K, Ohno, H, Tsujimoto   +11 more
openaire   +2 more sources

T Cell Epitopes in Japanese Cedar (Cryptomeria japonica) Pollen Allergens: Choice of Major T Cell Epitopes in Cry j 1 and Cry j 2 Toward Design of the Peptide-Based Immunotherapeutics for the Management of Japanese Cedar Pollinosis

The Journal of Immunology, 1998
AbstractJapanese cedar pollinosis is caused by exposure to Japanese cedar (Cryptomeria japonica) pollen, of which two components, Cry j 1 and Cry j 2, are believed to be the major allergens. T cell lines specific to either Cry j 1 or rCry j 2 were reactive to various portions of each panel of overlapping peptides derived from Cry j 1 or Cry j 2.
T, Sone, K, Morikubo, M, Miyahara, N, Komiyama, K, Shimizu, H, Tsunoo, K, Kino   +6 more
openaire   +2 more sources

Antigenic analysis of Cryptomeria japonica and Chamaecyparis obtusa using anti-Cry j 1 monoclonal antibodies.

Acta oto-laryngologica. Supplementum, 1997
In Japan, pollen of Cryptomeria japonica and Chamaecyparis obtusa are a yearly source of distress for many people suffering seasonally from allergic rhinitis. To study common epitopes shared by the two species, two monoclonal antibodies (moAbs) were raised against Cry j 1, which is the most predominant allergen in C. japonica.
M, Suzuki, M, Ito, H, Ito, S, Baba, I, Takagi, H, Yasueda, N, Ohta   +6 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Monoclonal Antibody and IgE Binding to Purified Natural Cry j 1

Journal of Allergy and Clinical Immunology, 2011
S. Wünschmann, B.P. Brooks, A.E. Koid, K. Ichikawa, M.D. Chapman   +4 more
openaire   +1 more source