Results 121 to 130 of about 55,954 (213)

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM. [PDF]

Nat Commun
Afrin S, Nguyen BA, Singh V, Singh P, Bassett P, Pekala M, Evers B, Lopez C, Ahmed Y, Li L, Kallem RR, Lemoff A, Argyropoulos C, Kluve-Beckerman B, Saelices L.   +14 more
europepmc   +1 more source

Poly(Ionic) Liquid‐Enhanced Ion Dynamics in Cellulose‐Derived Gel Polymer Electrolytes

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Advancing Energy Storage: Gel Polymer Electrolytes with Promising Potential Gel polymer electrolytes (GPEs) incorporating methyl cellulose and a range of ionic/polymeric achieved Li+ transference numbers comparable to traditional liquid electrolytes.
Tiago G. Paiva, Maykel Klem, Sara L. Silvestre, João Coelho, Neri Alves, Elvira Fortunato, Eurico J. Cabrita, Marta C. Corvo   +7 more
wiley   +1 more source

Lithium Metal Anode Fabrication: Methods, Challenges, and Strategies

EcoEnergy, EarlyView.
Schematic illustration of four representative fabrication techniques for thin lithium metal anodes: extrusion, molten lithium infusion, electroplating, and physical vapor deposition (PVD). ABSTRACT The pursuit of ultra‐high energy‐dense lithium‐metal batteries (LMBs) has reignited the drive to fabricate ultrathin high‐quality lithium metal anodes. This
Ji Hyun Baek, Mi Ji Kang, Ho Won Jang
wiley   +1 more source

Cryo-EM reveals how cardiomyopathy therapeutic drugs modulate the myosin motors of the heart. [PDF]

Sci Adv
Somavarapu AK, Ge J, Yengo CM, Craig R, Padron R.   +4 more
europepmc   +1 more source

Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis: A shared phenotype across brain‐expressed sodium channelopathies

Epilepsia, EarlyView.
Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli, Sebastian Ortiz, Tobias Brünger, Francesca Furia, Carmen Barba, Trine Bjørg‐Hammer, Ingo Borggraefe, Roberto Caraballo, Sebahattin Cirak, Alberto Espeche, Walid Fazeli, Renzo Guerrini, Matias Juanes, Karin Kassahn, Maria Kinali, Johannes Krämer, Judith Kröll, Maria Concepción Miranda Herrero, Renske Oegema, Katrin Ounap, Oscar Peñuela, Konrad Platzer, Asuri Narayan Prasad, Aurora Pujol, Karit Reinson, Alfonso Represa, Eugenia Roza, Gabriela Reyes Valenzuela, Agustí Rodríguez‐Palmero, Suzanne Sallevelt, Maria Iciar Sanchez‐Albiusa, Ingrid E. Scheffer, Cory Smid, Carl E. Stafstrom, Eva‐Lena Stattin, Jen R. Suarez, Steffen Syrbe, Kette D. Valente, Matias Wagner, Saskia Wortmann, Elena Gardella, Dennis Lal, Andreas Brunklaus, Rikke S. Møller   +43 more
wiley   +1 more source

High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit. [PDF]

Nat Commun
Park K, Yoo Y, Jeon H, Choi K, Kim H, Kwon E, Lim HH, Kim DY, No KT.   +8 more
europepmc   +1 more source

Artificial intelligence–driven decoupling structure–activity relationship for lithium‐ion batteries

InfoScience, EarlyView.
Artificial intelligence can efferently accelerate the high‐throughput screening of battery materials, the analysis of multiphase mechanisms, and the precise prediction of capacity and cycle life. This review systematically summarizes the applications of machine learning (ML) in decoupling the complex structure‐activity relationships of lithium‐ion ...
Tao Wang, Yuhang Meng, Tianhao Chen, Xiangfen Jiang, Yoshio Bando, Jinjue Zeng, Xuebin Wang   +6 more
wiley   +1 more source

Ultrathin liquid cells for microsecond time-resolved cryo-EM. [PDF]

Nat Commun
Curtis WA, Wenz J, Krüger CR, Barrass SV, Drabbels M, Lorenz UJ.   +5 more
europepmc   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source