Results 121 to 130 of about 6,328,527 (298)
Advanced Materials Interfaces, EarlyView.Thermoplastic attachment is introduced as a scalable surface coating strategy to improve the durability and dielectric reliability of flexible electrodynamic dust shields. By embedding chemically modified reduced graphene oxide (CMrGO) electrodes within thermoplastic laminates, mechanical degradation, abrasion damage, and vacuum‐induced electrical ...
Ide E. Onal +6 more
wiley +1 more source
Cryo-EM data collection, refinement, and validation statistics.
Cryo-EM data collection, refinement, and validation statistics.
Jianting Zheng (1616659) +5 more
core +3 more sources
Cryo-EM maps of LolCDE in different states.
, 2022 (A) Location of the 2 AMPPNP (red spheres) and Mg2+ (green spheres) molecules clamped between the 2 LolD subunits (left). Cryo-EM densities (deep blue mesh) for the AMPPNP and Mg2+ in AMPPNP-LolCDE (right).
Yihua Huang (245089) +6 more
core +1 more source
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
Classification in cryo-electron tomograms
, 2019 Different imaging techniques allow us to study the organization of life at different scales. Cryo-electron tomography (cryo-ET) has the ability to three-dimensionally visualize the cellular architecture as well as the structural details of macro ...
Förster, F.G. +24 more
core
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
A fragment based method for modeling of protein segments into cryo-EM density maps
BMC Bioinformatics, 2017 Background Single-particle analysis of electron cryo-microscopy (cryo-EM) is a key technology for elucidation of macromolecular structures. Recent technical advances in hardware and software developments significantly enhanced the resolution of cryo-EM ...
Jochen Ismer +3 more
doaj +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus
Advanced Science, EarlyView.Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto +5 more
wiley +1 more source
eLifeCryo-EM single-particle analyses typically require target macromolecule concentration at 0.05~5.0 mg/ml, which is often difficult to achieve. Here, we devise Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct structural ...
Yasuhiro Arimura +2 more
doaj +1 more source