Results 101 to 110 of about 55,954 (213)

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

A universal Fab targeting a conserved U1A-RNA epitope for RNA structure determination by cryo-EM. [PDF]

Nucleic Acids Res
Filippova EV, Krochmal D, Mukherjee S, Piccirilli JA, Kossiakoff AA.   +4 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Structural analysis of Cu/Zn-superoxide dismutase linked to neurodegenerative disease by antibody-guided cryo-EM. [PDF]

Protein Sci
Shino Y, Muraki N, Kobatake Y, Kamishina H, Kosuge H, Nakakido M, Tsumoto K, Furukawa Y.   +7 more
europepmc   +1 more source

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Cryo-EM Structure of the FtsH Periplasmic Domain Reveals Functional Dynamics. [PDF]

ACS Chem Biol
Göc G, Yadav SKN, Orriss G, Borucu U, Berger I, Schaffitzel C, Kabasakal BV.   +6 more
europepmc   +1 more source

H2O2 Activation and Alkane Oxidation by Copper Complexes With R‐dpa N3‐Tridentate Ligands: The Complex‐Based Dicopper Active Species as a Key Feature in the Efficient Alkane Oxidation

Chemistry – A European Journal, EarlyView.
Two reaction pathways, Paths 1 and 2, are involved in H2O2 activation by Cu complexes with N3‐tridentate ligands, depending on the ease of bridging structure formation. In Path 1, hydroxy radical (HO•) is formed from a hydroperoxo Cu(II) intermediate. In Path 2, a relevant complex‐based μ‐O• bridged Cu(II)2 active species is formed from a bis‐μ‐oxo Cu ...
Kyosuke Fujikawa, Momoe Kawahashi, Alexander Granichny, Siegfried Schindler, Hiroaki Kitagishi, Masahito Kodera   +5 more
wiley   +1 more source

Oligomeric assemblies of plant biotin carboxylase revealed by cryo-EM and cross-linking. [PDF]

Biochem J
Madison HJ, Dunn L, You Y, Lemes Jorge G, Paša-Tolić L, Thelen JJ, Van Doren SR, Yokom AL.   +7 more
europepmc   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, EarlyView.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

Cryo-EM reveals ArnA contamination during purification of a ciliary protein complex. [PDF]

Acta Crystallogr D Struct Biol
Jiang X, Kikkawa M.
europepmc   +1 more source