Results 91 to 100 of about 59,949 (213)

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Sub 3Å cryoEM structure using a standard LaB6 120kV TEM upgraded with direct electron detector [PDF]

BIO Web of Conferences
Venugopal Hari, Mobbs Jesse, Taveneau Cyntia, Fox Daniel, Knott Gavin, Grinter Rhys, Thal David, Ramm Georg   +7 more
doaj   +1 more source

Cryo-electron microscopy-based drug design

Frontiers in Molecular Biosciences
Structure-based drug design (SBDD) has gained popularity owing to its ability to develop more potent drugs compared to conventional drug-discovery methods.
Ecenur Cebi, Joohyun Lee, Vinod Kumar Subramani, Nayeon Bak, Changsuk Oh, Kyeong Kyu Kim   +5 more
doaj   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Overcoming Interfacial Hurdles in Solid‐State Aluminum Batteries for Safe and Energy‐Dense Storage

Advanced Science, EarlyView.
Solid‐state aluminum batteries (SSABs) promise high energy density and intrinsic safety but face severe solid–solid interfacial challenges. This review reveals the three core hurdles—anode passivation, cathode contact loss, and electrolyte grain boundary resistance and discusses strategies including artificial interphases, alloying, and composite ...
Yunlei Wang, Xiaogang Zhang, Mingguang Wang, Yifan Wu, Shitao Dou, Taibin Wu   +5 more
wiley   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Disorder‐Driven Ionic Mobility Edge and Localization‐Driven Dendrite Formation in Solid Electrolytes

Advanced Energy Materials, EarlyView.
Migration‐barrier disorder localizes ionic transport into a sparse percolation backbone. Current and electric‐field focusing at filament tips promote fractal dendrite growth and suppress the critical current density according to jcrit = j0 exp(−σEeff/kBT).
Dongwook Lee, Jiwon Seo
wiley   +1 more source

Atomic‐Scale Tracing of Lithium Trapped in Copper Current Collectors

Advanced Energy Materials, EarlyView.
Does lithium diffuse into the copper current collector during cycling in lithium‐metal batteries? This study unveils, at the atomic scale, that lithium is trapped at grain boundaries and junctions, already after only one plating/stripping cycle. After three and more cycles, the copper foil surface becomes nanocrystalline and oxidized.
Tong Li, Carlo Franke, Ziyuan Lyu, Omair Ashfaq, Mervyn Soans, Mohsen Sotoudeh, Thomas Diemant, Jun Xia, Aleksander Kostka, Dominic Bresser   +9 more
wiley   +1 more source