Results 111 to 120 of about 55,954 (213)

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solution. [PDF]

Protein Sci
Lepesheva GI, Hargrove TY, Ren Y.
europepmc   +1 more source

Azidophosphonamido Rhodium(I) and Iridium(I) Complexes: Synthesis, Properties, and Linkage Isomerism

Chemistry – A European Journal, EarlyView.
A family of azidophosphonamido ligands and their corresponding rhodium(I) and iridium(I) complexes were synthesized. The rich reaction chemistry of these species revealed unusual linkage isomerization processes and bonding motifs. M = Rh, Ir; Mes = 2,4,6‐Me3C6H2. ABSTRACT A series of azidophosphonamido rhodium(I) and iridium(I) complexes ([iPr2P(N3R)NR]
Emily L. Trew, Daisy E. Cruz‐Milette, Douglas Turnbull, Paul G. Hayes   +3 more
wiley   +1 more source

Cryo-EM structures of NHEJ assemblies with nucleosomes. [PDF]

Nat Commun
Hall C, Frit P, Kefala-Stavridi A, Pelletier A, Hardwick SW, Amin H, Bilyard MK, Maia De Oliviera T, Tariq A, Zahid S, Chirgadze DY, Balasubramanian S, Meek K, Ropars V, Charbonnier JB, Modesti M, Calsou P, Britton S, Blundell TL, Schalch T, Chaplin AK.   +20 more
europepmc   +1 more source

Artificial intelligence in enzyme catalysis: Emerging trends and applications in biocatalyst engineering

The Canadian Journal of Chemical Engineering, EarlyView.
Schematic representation of artificial intelligence approaches in enzyme catalysis, integrating bibliometric analysis, emerging research trends, and machine learning tools for enzyme design, prediction, and industrial biocatalytic applications. Abstract This study systematically explores the applications of artificial intelligence (AI) in enzyme ...
Misael Bessa Sales, Francisco Izaias da Silva Aires, Paulo Gonçalves de Sousa Junior, Calebe Da Rocha Silva, Emanuel Lino Rodrigues, Maria Cristiane Martins de Souza, José C. S. dos Santos   +6 more
wiley   +1 more source

Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM. [PDF]

Protein Sci
Park J, Gouaux E.
europepmc   +1 more source

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Fine-tuning AlphaFold with limited cryo-EM observations. [PDF]

Commun Chem
Liao J, Zheng D, Zhang H, Zhang L, Hu M, Bao C.   +5 more
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Cryo-EM structures and transport mechanism of human multifunctional transporter BTR1. [PDF]

Protein Cell
Liu C, Chen X, Chang L, Li T, Hao Z, Wang Z, Cui K, Zhang C, Wang J, Guo L, Zhang S, Mao J, Xie J, Li Y, Yang M.   +14 more
europepmc   +1 more source