Results 111 to 120 of about 6,313,615 (343)
Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy
Advanced Materials, EarlyView.MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo +9 more
wiley +1 more source
`Mix-it-up': accessible time-resolved cryo-EM on the millisecond timescale
IUCrJBiological reactions often involve macromolecules that undergo substrate-induced conformational changes in under a second, yet capturing these transient states remains challenging. While high-resolution structural techniques such as X-ray crystallography
Lauren Alexandrescu +2 more
doaj +1 more source
Cryo-EM and time-resolved cryo-EM studies on translation
, 2015 Translation is the process by which the cell produces new proteins on the ribosome, as directed by genetic instructions, in all living organisms. Structural studies of the ribosome have shed considerable lights on its mechanism and regulation. Cryogenic electron microscopy (cryo-EM) and single-particle reconstruction technique is one of the major ...
openaire +2 more sources
, 2023 (A) Atomic model of the CupE pilus, consisting of CupE1 subunits, in the transparent cryo-EM density at 15 σ away from the mean. (B) The same density shown in (A) coloured according to local resolution. (C) Independent half-map FSC curve.
Vikram Alva (194229) +10 more
core +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
Cryo-EM Data Collection, Refinement and Validation Statistics for HMPV F in complex with scFv MPE8.
, 2023 Cryo-EM Data Collection, Refinement and Validation Statistics for HMPV F in complex with scFv MPE8.
Ruth A. Woodward (17027779) +19 more
core +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
The resolution revolution revisited
IUCrJIn this issue of IUCrJ, Subramaniam, Kühlbrandt & Henderson present an overview of the remarkable progress that has been made in electron cryo-microscopy and electron cryo-tomography.
Edward H. Egelman
doaj +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Cryo-EM data collection and refinement statistics.
Cryo-EM data collection and refinement statistics.
Guibo Rao (5545862) +15 more
core +1 more source