Results 111 to 120 of about 59,949 (213)

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Affinity purification contaminants identified by cryo-EM and mass spectrometry. [PDF]

Biosci Rep
Belcher ER, Hardwick SW, Maia de Oliveira T, Hyvönen M.   +3 more
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Spatially Coupled Cl2 Confinement and Activation at Curved Ni Single‐Atom Sites for Highly Reversible Li–Cl2 Batteries

Angewandte Chemie, EarlyView.
A robust cathode featuring curvature‐engineered Ni single‐atoms anchored within hierarchical pores effectively confines Cl2 and accelerates Cl0/Cl−1 redox kinetics. This synergistic architecture unlocks the potential of Li‐Cl2 secondary batteries with an unprecedented 1×106 mAh g−1 cumulative capacity, all‐climate resilience (–40°C to + 70°C), and 7.65
Minggang Xie, Keren Jiang, Xuehai Tan, Xuesong Xie, Zheng Cheng, Xianbin Meng, Yuxuan Xue, Yi Guan, Zhixuan Chen, Yifan Li, Renfei Feng, Zhi Li   +11 more
wiley   +2 more sources

A cryo-EM processing pipeline for microtubules using CryoSPARC. [PDF]

Acta Crystallogr D Struct Biol
Zhang D, Muñoz-Hernández H, Filipcik P, Sejwal K, Xu Y, Choi SR, Steinmetz MO, Wieczorek M.   +7 more
europepmc   +1 more source

Protein Engineering-Enabled Cryo-EM Investigation of Small GTPases. [PDF]

J Mol Biol
Hu Z, Patel UR, Glasser E, Koide A, Koide S.   +4 more
europepmc   +1 more source

Azole γ‐Peptides Helix Switching via Heterocycle Substitutions

Angewandte Chemie, EarlyView.
Heterocycle substitution in azole‐based γ‐amino acids enables control over the helical shape of heterocyclic γ‐peptides. S↔N permutation in thiazole residues switches a canonical 9‐helix into a flexible helix exhibiting discontinuous hydrogen bonding.
Samantha Chaise, Claude Didierjean, Audrey Gacogne, Maxime Fillaudeau, Young Kee Kang, Aurélien Lebrun, Jean‐Louis Bantignies, Dominique Housset, Muriel Amblard, Ludovic T. Maillard, Baptiste Legrand   +10 more
wiley   +2 more sources

Making sense of invisible densities in single-particle cryo-EM. [PDF]

IUCrJ
Lin X, Cheng Y.
europepmc   +1 more source

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, EarlyView.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

KNexPHENIX: A PHENIX-Based Workflow for Improving Cryo-EM and Crystallographic Structural Models. [PDF]

J Chem Inf Model
Nandi S, Conn GL.
europepmc   +1 more source