Results 131 to 140 of about 55,954 (213)
Advances in cryo-EM that have shaped mechanistic models of membrane-attack-complex assembly and regulation. [PDF]
IUCrJNoone DP, Bubeck D.
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Interdisciplinary Medicine, EarlyView.This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma +6 more
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Bayesian perspective for orientation determination in cryo-EM with application to structural heterogeneity analysis. [PDF]
Acta Crystallogr D Struct BiolXu S, Balanov A, Singer A, Bendory T.
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Journal of the Chinese Chemical Society, EarlyView.While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
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Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology
Journal of the Chinese Chemical Society, EarlyView.Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
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Macromolecular Rapid Communications, EarlyView.Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger +8 more
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Visualizing the mechanism of quinol oxidation and inhibition of a <i>bd</i>-type oxidase using cryo-EM. [PDF]
Sci Advvan der Velden TT +4 more
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Macromolecular Rapid Communications, EarlyView.We establish a correlation between the mid‐IR photonic response of Passive Daytime Radiative Cooling systems and their thermal radiation performances, characterized within a dedicated setup that simulates the irradiance toward outer space under controlled and reproducible conditions.
Emma Spotorno +5 more
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Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
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Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis
Muscle &Nerve, EarlyView.ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick +4 more
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