Results 171 to 180 of about 6,313,615 (343)
Angewandte Chemie, EarlyView.Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu +3 more
wiley +2 more sources
Author response: Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching [PDF]
Kexin Zhang +2 more
openalex +1 more source
Advanced Intelligent Discovery, EarlyView.AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula +10 more
wiley +1 more source
Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance
Angewandte Chemie, EarlyView.The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato +10 more
wiley +2 more sources
Cryo-EM sample preparation of liposome-bound rotaviruses.
Schematic illustration of the interaction between rotavirus and a liposome during specimen preparation for cryo-EM analysis. (TIF)
Stephen C. Harrison (9731984) +4 more
core +1 more source
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources
Angewandte Chemie, EarlyView.A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu +7 more
wiley +2 more sources
Acoustofluidic cryo-EM enables in situ particle manipulation for uniform, high-quality cryo-EM specimens. [PDF]
Sci AdvYang K +21 more
europepmc +1 more source
Cryo-electron tomography for the structural study of mitochondrial translation
, 2019 Cryo-electron tomography (cryo-ET) enables the three-dimensional (3D) structural characterization of macromolecular complexes in their physiological environment.
Englmeier, Robert +3 more
core