Results 171 to 180 of about 59,949 (213)

The Differing Phenotypes of the Three Most Common Postsynaptic Congenital Myasthenic Syndromes Governed by Their Underlying Molecular Pathogenic Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT The congenital myasthenic syndromes are rare disorders of impaired signal transmission at the neuromuscular junction. Despite next generation sequencing facilitating the identification of variants in myasthenic‐associated genes, these variants are frequently of unknown significance and the clinical diagnosis can be delayed.
David Beeson
wiley   +1 more source

Cryo-EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits. [PDF]

Adv Sci (Weinh)
Wang W, Zerang Z, You L, Liu Z, Nie R, Qi F, Gao F, Zhao C, Ma W, He J, Wang X, Wu S, Liu B, Liu X, Lei D, Zhi D, Wang D.   +16 more
europepmc   +1 more source

Polylactide/Graphene Nanoplatelet Composites for Advanced Functional Applications

Polymer Composites, EarlyView.
Polylactide/Graphene nanoplatelet composites for advanced functional applications. ABSTRACT This study investigates the structure–property relationships of polylactide (PLA) nanocomposites containing graphene nanoplatelets (GNP) and trimellitic anhydride‐modified GNPs (TMA‐GNP).
Shivanthi Dharmarathna, Haritha Haridas, Hadi Hosseini, Mehdi Babazadeh, Carlos E. Saavedra, Marianna Kontopoulou   +5 more
wiley   +1 more source

Cryo-EM structures reveal a conserved architecture for raiA noncoding RNA. [PDF]

Nucleic Acids Res
He Y, Zhong J, Yang Y, Gunsalus RP, Zhou ZH, Feigon J.   +5 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain. [PDF]

Nat Commun
Fabrizio M, Brewer M, Bogdanović N, Zhao C.   +3 more
europepmc   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Strategic advances for cryo-EM structural studies of small (<100 kDa) GPCRs. [PDF]

Commun Biol
Singh SK, Agrawal M, Pattanayak A, Baidya M, Kumari P.   +4 more
europepmc   +1 more source

An (αβ)2 Architecture of the Arabidopsis thaliana tRNA Splicing Endonuclease Complex: Structural Modeling and Evolutionary Analyses

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre‐tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular fluorescence complementation (BiFC) assays with AlphaFold3 (AF3)‐based structural modeling, molecular ...
Mohammad Moniruzzaman, Markus Englert, Kazuhito Akama   +2 more
wiley   +1 more source

Cryo-EM structure of the SRI-HtrI complex reveals the cytoplasmic coupling in an archaeal phototaxis system. [PDF]

Nat Commun
Lim GZ, Lin YE, Chen PC, Fu HY, Yang CS.
europepmc   +1 more source