A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex.
BloodÜstok FI, Faille A, Huntington JA.
europepmc +1 more source
Uncovering the structural impact of KatG Ser315 mutations in Mycobacterium tuberculosis via cryo-EM. [PDF]
Protein SciAllport T, Chaplin AK.
europepmc +1 more source
Polymer Composites, EarlyView.Microfibrillar composite containing highly oriented, plasma‐treated PA6 microfibrils embedded within the polymer matrix. ABSTRACT Plasma treatment is often used to alter chemical surface characteristics of fibers or polymers, improving dispersion of components and interfacial adhesion between incompatible constituents in composites.
Nam Kyeun Kim +5 more
wiley +1 more source
Predicting water at the protein interface in cryo-EM structures from MD-excess chemical potential. [PDF]
Biophys JSun Q +7 more
europepmc +1 more source
Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink +5 more
wiley +1 more source
Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex. [PDF]
Nat CommunWang S +4 more
europepmc +1 more source
Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras +5 more
wiley +1 more source
Comparing multislice projections of MD simulations with cryo-EM exposes structural prediction errors. [PDF]
Biophys JMohammed A +6 more
europepmc +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas +3 more
wiley +1 more source
A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors
Small, EarlyView.The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang +4 more
wiley +1 more source