Results 201 to 210 of about 6,313,615 (343)

Quantized neural representation for lossy cryo-EM compression. [PDF]

Bioinformatics
Duan X, Shao Y, Meng Z, Xu Z, Han J, Tu C, Wang Y, Han R, Zeng Q.   +8 more
europepmc   +1 more source

Cryo-EM structure of the sub-50 kD PDZ-RhoGEF catalytic core–RhoA complex reveals an allosteric mechanism for GEF switch [PDF]

Matthew Villanueva Braga, Emma Barpal, Sheng Li, Jennifer N. Cash   +3 more
openalex   +1 more source

Reviewer #3 (Public review): Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

openalex   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Nucleocapsid-like cryo-EM structure of influenza B virus. [PDF]

PLoS Pathog
Thirion M, Stelfox AJ, Chenavier F, Chomat H, Isel C, Freslon LL, Zarkadas E, Ruigrok RWH, Naffakh N, Crépin T, Ballandras-Colas A.   +10 more
europepmc   +1 more source

eLife Assessment: Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

Sjors H. W. Scheres
openalex   +1 more source

The 2010 cryo‐em modeling challenge [PDF]

Biopolymers, 2012
Steven J, Ludtke, Catherine L, Lawson, Gerard J, Kleywegt, Helen, Berman, Wah, Chiu   +4 more
openaire   +2 more sources

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1. [PDF]

Nat Struct Mol Biol
Ciapponi M, Cafiso M, Schkölziger S, Benda C, Bonnet J, Müller J.   +5 more
europepmc   +1 more source