Identifying effective cryoprotection agents for non-model bacterial species. [PDF]
Microbiol SpectrWright R, Abbot B, Yonemura T, Carter M.
europepmc +1 more source
Synchrotron‐based multi‐scale biological imaging inside biocontainment environments
Journal of Synchrotron Radiation, Volume 33, Issue 5, Page 1245-1254, September 2026.Orion, the first BSL‐4 synchrotron‐based research complex, advances pathogen research by integrating cutting‐edge, multi‐scale imaging to enhance the understanding of infectious diseases and inform global health policies.The Orion project is designed to be a state‐of‐the‐art research complex that studies dangerous pathogens, located at the Brazilian ...
Mateus Borba Cardoso +10 more
wiley +1 more source
Lessons From Drug Discovery for Cryoprotective Agent Design: An AI-Oriented Perspective. [PDF]
Adv Sci (Weinh)Wilczok D +4 more
europepmc +1 more source
Establishment of a field-adapted biotechnological protocol for Duck semen cryopreservation. [PDF]
Poult SciBernardi O, Reverchon M.
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Avoiding pitfalls when modelling ligands in macromolecular crystallography
Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart +4 more
wiley +1 more source
Evaluation of Deep Eutectic Solvents for Cryopreservation of the Fish Pathogen <i>Saprolegnia parasitica</i>. [PDF]
Methods ProtocDelimar S +3 more
europepmc +1 more source
Towards routine accurate electron‐density studies of biological macromolecules
Acta Crystallographica Section D, Volume 82, Issue 9, Page 1044-1055, September 2026.Here, we describe the determination of the highest resolution structure in the PDB at 0.43 Å resolution. Electron‐density maps reveal extensive deformation electron density that is completely accounted for by performing transferable aspherical atom refinements using the DiSCaMB library in BUSTER.We report here the structure of Pyrococcus abyssi ...
Elham Paknia +10 more
wiley +1 more source
Advanced lyophilized mesenchymal stem cell-conditioned medium formulation improves therapeutic efficacy in skin wound repair. [PDF]
Regen BiomaterChen X, Li B, Gu W, Li M, Zhang Z.
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HOMOGENEOUS NUCLEATION AT HIGH-PRESSURES IN SOME AQUEOUS-SOLUTIONS OF CRYOPROTECTANT INTEREST
, 1988 HOMOGENEOUS NUCLEATION AT HIGH-PRESSURES IN SOME AQUEOUS-SOLUTIONS OF CRYOPROTECTANT ...
DR MACFARLANE (14531879) +1 more
core
Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter +8 more
wiley +1 more source