Results 1 to 10 of about 1,064 (143)

Design of a new lyoprotectant increasing freeze-dried Lactobacillus strain survival to long-term storage [PDF]

BMC Biotechnology, 2021
Background Stabilization of freeze-dried lactic acid bacteria during long-term storage is challenging for the food industry. Water activity of the lyophilizates is clearly related to the water availability and maintaining a low aw during storage allows ...
Aurore Bodzen, Beney Laurent, Sebastien Dupont   +2 more
exaly   +4 more sources

Effectiveness of Lyoprotectants in Protein Stabilization During Lyophilization [PDF]

Pharmaceutics
Background: Proteins are commonly used in the healthcare industry to treat various health conditions, and most proteins are sensitive to physical and chemical changes. Lyophilization, also known as freeze-drying, involves sublimating water in the form of
Vinoothini Karunnanithy, Nur Hazirah Binti Abdul Rahman, Nur Atiqah Haizum Abdullah, Mh Busra Fauzi, Yogeswaran Lokanathan, Angela Ng Min Hwei, Manira Maarof   +6 more
doaj   +3 more sources

Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine [PDF]

npj Vaccines, 2023
Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs).
Mingyuan Li, Lin Jia, Yanbo Xie, Wenlin Ma, Zhihong Yan, Fufeng Liu, Jie Deng, Ali Zhu, Xue Siwei, Wen Su, Xiaofeng Liu, Shiqin Li, Haomeng Wang, Peng Yu, Tao Zhu   +14 more
doaj   +3 more sources

Screening of Superior Lactic Acid Bacteria from Sourdough and Optimization of Freeze-Dried Bacterial Powder Preparation Technology for Steamed Buns [PDF]

Foods
To address the industrialization limitations of traditional sourdough and develop high-performance direct-vat-set (DVS) starters for steamed buns, this study screened superior lactic acid bacteria (LAB) and optimized the preparation technology of freeze ...
Huadi Sun, Lulu Pan, Shunzhi Zhang, Guiting Zhao, Ruixiang Zhao   +4 more
doaj   +2 more sources

Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization [PDF]

Foods
Probiotics hold considerable promise for treating and preventing inflammatory disease; however, their application is often limited by unclear anti-inflammatory mechanisms and reduced viability following lyophilization.
Bista Sunita, Yuxing Liu, Hanwei Zheng, Yue Su, Mingyue Liu, Linfeng Xu, Ikram Alouk, Zhiqing Liu, Wenyong Lou   +8 more
doaj   +2 more sources

Development and Characterization of a Stable Oil-in-Water Nanoemulsion Using Impingement Jet Mixing and Lyophilization Techniques [PDF]

Pharmaceutics
Nanoemulsion (NEM) is an effective adjuvant and delivery system for vaccines and nucleic acids, capable of inducing immune responses against diverse pathogens. Background/Objectives: Conventional NEM manufacture uses multi-step operations, typically high-
Anna Shao, Jingyan Zhang, Zhaowei Jin, Yao Li, Jialin Tang, Quanmin Chen, Hongbing Wu, Jeremy Guo   +7 more
doaj   +2 more sources

Effects of lyophilized Lactiplantibacillus plantarum DC2 probiotic powder on gastrointestinal morphology and microbiota in mice [PDF]

Frontiers in Microbiology
Probiotics have potential benefits in modulating gastrointestinal function. However, their efficacy and application depend largely on specific bacterial strains and environmental contexts. In our previous study, a strain of Lactiplantibacillus plantarum (
Juzuo Zhang, Jun Jiang, Mingyu Wang, Demiao Zeng, Junfei Xu   +4 more
doaj   +2 more sources

Preparation, characterization and in vitro evaluation of atorvastatin nanosuspensions. [PDF]

PLoS ONE
Poorly water-soluble drugs present a significant challenge for pharmaceutical development, particularly affecting the pharmacokinetics of orally administered drugs due to their poor dissolution.
Yaman Ahmad Akour, Ahmad Aljaberi, Saja H Hamed, Alaa Altaher, Eman M Migdadi   +4 more
doaj   +2 more sources

A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART) [PDF]

Bioengineering, 2022
Recently, various innovative technologies have been developed for the enhanced delivery of biologics as attractive formulation targets including polymeric micro and nanoparticles.
Niloofar Heshmati Aghda, Yu Zhang, Jiawei Wang, Anqi Lu, Amit Raviraj Pillai, Mohammed Maniruzzaman   +5 more
doaj   +2 more sources

Impact of nanocarrier aggregation on EPR-mediated tumor targeting [PDF]

Frontiers in Bioengineering and Biotechnology, 2023
The aim of this study was to investigate the influence of excipients on retaining the particle size of methotrexate (MTX) loaded chitosan nanocarriers (CsNP) during lyophilization, which relates to the ability to enlarge the particle size and target ...
S. P. Surya Teja, N. Damodharan, T. Tamilanban, Vetriselvan Subramaniyan, Vetriselvan Subramaniyan, V. Chitra, Suresh V. Chinni, Suresh V. Chinni, Ling Shing Wong, Neeraj Kumar Fuloria, Mahendran Sekar, Shivkanya Fuloria, Gobinath Ramachawolran, Siddharthan Selvaraj   +13 more
doaj   +2 more sources