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Design of a new lyoprotectant increasing freeze-dried Lactobacillus strain survival to long-term storage [PDF]
BMC Biotechnology, 2021 Background Stabilization of freeze-dried lactic acid bacteria during long-term storage is challenging for the food industry. Water activity of the lyophilizates is clearly related to the water availability and maintaining a low aw during storage allows ...
Aurore Bodzen +2 more
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Effectiveness of Lyoprotectants in Protein Stabilization During Lyophilization [PDF]
PharmaceuticsBackground: Proteins are commonly used in the healthcare industry to treat various health conditions, and most proteins are sensitive to physical and chemical changes. Lyophilization, also known as freeze-drying, involves sublimating water in the form of
Vinoothini Karunnanithy +6 more
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Stability study of azelaic acid proethosomes with lyoprotectant as stabilizer
Journal of Advanced Pharmaceutical Technology & Research, 2018 The ethosomal carrier system can increase the penetration of azelaic acid into the stratum corneum, but ethosomes have both physical (particle aggregation or fusion) and chemical instability (chemical interaction of active ingredients during storage ...
Hervianti Nurfitria Nugrahani +2 more
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Assessment and determination of lyoprotectant for survival of freeze-dried Lactobacillus rhamnosus
Acta Universitatis Cibiniensis. Series E: Food Technology, 2016 Currently research of lactic acid bacteria focus primarily on the functional probiotics, which are major beneficial biota in the gastrointestinal tract, have been industrial manufactured.
Miao Zongcheng, Zhao Yang, Huo Xiaoping
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Biomolecules, 2023 Astaxanthin is a carotenoid with excellent antioxidant activity. However, this small lipid-soluble molecule is insoluble in water and has low stability. Although this situation can be improved when astaxanthin is prepared as a nanosuspension, the aqueous
Yingyuan Zhao, Ruifang Li
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Lyoprotectant Constituents Suited for Lyophilization and Reconstitution of Stem-Cell-Derived Extracellular Vesicles [PDF]
Biomaterials ResearchStem-cell-derived extracellular vesicles (EVs) are emerging as an alternative approach to stem cell therapy. Successful lyophilization of EVs could enable convenient storage and distribution of EV medicinal products at room temperature for long periods, thus considerably increasing the accessibility of EV therapeutics to patients.
Chi Young Bang +2 more
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The Effects of Lyophilization on the Physico-Chemical Stability of Sirolimus Liposomes [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: The major limitation in the widespread use of liposome drug delivery system is its instability. Lyophilization is a promising approach to ensure the long-term stability of liposomes.
Parvin Zakeri-Milani +2 more
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Effect of Lyoprotectant on the Solubility and Structure of Silk Sericin
International Journal of Industrial Entomology, 2012 【To increase the solubility of lyophilized sericin, we added three types of lyoprotectant: sucrose, trehalose and dextran. The addition of lyoprotectant increased the solubility of lyophilized sericin especially when 1.0% of sucrose, 1.0% and 1.5% trehalose are added. The secondary structure of lyophilized sericin showed that the content of ${\beta}$
Moo-Kon Kim +5 more
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Journal of Dairy Science, 2022 : We evaluated the potential of whey protein hydrolysate as a lyoprotectant for maintaining the cell viability of Bifidobacterium animalis ssp. lactis Probio-M8 during freeze-drying and subsequent storage.
Haoqian Wang +7 more
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