Effectiveness of Lyoprotectants in Protein Stabilization During Lyophilization [PDF]
PharmaceuticsBackground: Proteins are commonly used in the healthcare industry to treat various health conditions, and most proteins are sensitive to physical and chemical changes. Lyophilization, also known as freeze-drying, involves sublimating water in the form of
Mh Busra Fauzi +2 more
exaly +7 more sources
Lyophilized Synthetic Platelets: In Vitro Characterization and In Vivo Evaluation in Mouse Thrombocytopenia Model [PDF]
Advanced SciencePlatelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks.
Ujjal Didar Singh Sekhon +20 more
doaj +3 more sources
Bioactive Hydrogel Supplemented with Stromal Cell-Derived Extracellular Vesicles Enhance Wound Healing [PDF]
PharmaceuticsBackground/Objectives: Skin regeneration is a rapidly advancing field with significant implications for regenerative medicine, particularly in treating wounds and burns.
Matteo Galbiati +12 more
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Design of a new lyoprotectant increasing freeze-dried Lactobacillus strain survival to long-term storage [PDF]
BMC Biotechnology, 2021 Background Stabilization of freeze-dried lactic acid bacteria during long-term storage is challenging for the food industry. Water activity of the lyophilizates is clearly related to the water availability and maintaining a low aw during storage allows ...
Aurore Bodzen +6 more
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Stabilization strategies and advancements in lyophilization to preserve integrity and efficacy of next-generation biologicals [PDF]
International Journal of Pharmaceutics: XThe success of mRNA-lipid nanoparticles (LNPs) vaccines during the COVID-19 pandemic has significantly increased global demand for stable, thermo-resistant biologicals.
Ravi Maharjan +9 more
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Development and Characterization of a Stable Oil-in-Water Nanoemulsion Using Impingement Jet Mixing and Lyophilization Techniques [PDF]
PharmaceuticsNanoemulsion (NEM) is an effective adjuvant and delivery system for vaccines and nucleic acids, capable of inducing immune responses against diverse pathogens. Background/Objectives: Conventional NEM manufacture uses multi-step operations, typically high-
Anna Shao +7 more
doaj +2 more sources
Fermentation of kefir with traditional freeze-dried starter cultures successfully recreates fresh culture fermented kefir [PDF]
Frontiers in MicrobiologyIntroductionInterest in fermented foods and their purported health benefits has led to increased scientific research investigating the development of starter cultures which maintain the characteristics of traditional products while allowing for ...
Maanasa Mudoor Sooresh +12 more
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Formulation, Characterization, and Antioxidant Properties of Chitosan Nanoparticles Containing Phenolic Compounds from Olive Pomace [PDF]
AntioxidantsOlive phenolic compounds like hydroxytyrosol (OH-Tyr), tyrosol (Tyr), and their precursors have different health-promoting properties, mainly based on their strong antioxidant capacity.
Ilaria Fierri +9 more
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Limosilactobacillus reuteri DSM 17938 Produce Bioactive Components during Formulation in Sucrose [PDF]
MicroorganismsImproved efficacy of probiotics can be achieved by using different strategies, including the optimization of production parameters. The impact of fermentation parameters on bacterial physiology is a frequently investigated topic, but what happens during ...
Ludwig Ermann Lundberg +6 more
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Pharmaceutics, 2021 The lyoprotective effects of mannitol and lactose have been evaluated in the production of sildenafil citrate liposomes. Liposomes were prepared by mixing the components under ultrasonic agitation, followed by a transmembrane pH gradient for remote drug ...
María José de Jesús Valle +5 more
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