Results 11 to 20 of about 1,064 (143)

The Effects of Lyophilization on the Physico-Chemical Stability of Sirolimus Liposomes [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: The major limitation in the widespread use of liposome drug delivery system is its instability. Lyophilization is a promising approach to ensure the long-term stability of liposomes.
Parvin Zakeri-Milani, Hadi Valizadeh, Saeed Ghanbarzadeh   +2 more
doaj   +3 more sources

Assessment and determination of lyoprotectant for survival of freeze-dried Lactobacillus rhamnosus

Acta Universitatis Cibiniensis. Series E: Food Technology, 2016
Currently research of lactic acid bacteria focus primarily on the functional probiotics, which are major beneficial biota in the gastrointestinal tract, have been industrial manufactured.
Miao Zongcheng, Zhao Yang, Huo Xiaoping
doaj   +2 more sources

Preparation and Application of Directed Vat Set Indigenous Freeze-Drying Lentilactobacillus hilgardii Q19 Starter in Winemaking

Foods, 2023
In order to prepare a better direct vat set for malolactic fermentation (MLF) in high ethanol and low pH wines, the high-ethanol- and low-temperature-tolerant strain Lentilactobacillus hilgardii Q19, which was isolated from the eastern foothill of the ...
Ling Wang, Gang Huang, Wen Ma, Gang Jin
doaj   +2 more sources

Stability study of azelaic acid proethosomes with lyoprotectant as stabilizer

Journal of Advanced Pharmaceutical Technology & Research, 2018
The ethosomal carrier system can increase the penetration of azelaic acid into the stratum corneum, but ethosomes have both physical (particle aggregation or fusion) and chemical instability (chemical interaction of active ingredients during storage ...
Hervianti Nurfitria Nugrahani, Iskandarsyah, Harmita   +2 more
doaj   +2 more sources

Physical Characteristics of Liposomal Formulation Dispersed in HPMC Matrix and Freeze-Dried Using Maltodextrin and Mannitol as Lyoprotectant [PDF]

Pharmaceutical Sciences, 2017
Background: The present study aims to design formulation of liposomes that are well-preserved during freeze-drying. The combination of Hydroxy Propyl Methyl Cellulose (HPMC) as dispersion matrix and lyoprotectants; maltodextrin or mannitol, was employed ...
Raditya Weka Nugraheni 1, Dwi Setyawan 1, Helmy Yusuf 1 *
doaj   +4 more sources

Response Surface Optimization of Lyoprotectant from Amino Acids and Salts for Bifidobacterium Bifidum During Vacuum Freeze-Drying

Acta Universitatis Cibiniensis. Series E: Food Technology, 2017
High quality probiotic powder can lay the foundation for the commercial production of functional dairy products. The freeze-drying method was used for the preservation of microorganisms, having a deleterious effect on the microorganisms viability.
Qi Kangru, Chen He, Wan Hongchang, Hu Man, Wu Yuxi   +4 more
doaj   +3 more sources

Limosilactobacillus reuteri DSM 17938 Produce Bioactive Components during Formulation in Sucrose [PDF]

Microorganisms
Improved efficacy of probiotics can be achieved by using different strategies, including the optimization of production parameters. The impact of fermentation parameters on bacterial physiology is a frequently investigated topic, but what happens during ...
Ludwig Ermann Lundberg, Manuel Mata Forsberg, James Lemanczyk, Eva Sverremark-Ekström, Corine Sandström, Stefan Roos, Sebastian Håkansson   +6 more
doaj   +2 more sources

Development of Robust Freeze-Drying Process for Long-Term Stability of rVSV-SARS-CoV-2 Vaccine [PDF]

Viruses
The thermostability of vaccines, particularly enveloped viral vectored vaccines, remains a challenge to their delivery wherever needed. The freeze-drying of viral vectored vaccines is a promising approach but remains challenging due to the water removal ...
MD Faizul Hussain Khan, Maryam Youssef, Sean Nesdoly, Amine A. Kamen   +3 more
doaj   +2 more sources

Thermostabilization of indigenous multiplex polymerase chain reaction reagents for detection of enterotoxigenic Staphylococcus aureus

Journal of Microbiology, Immunology and Infection, 2018
Background/Purpose: Among DNA-based techniques, polymerase chain reaction (PCR) is the most widely accepted molecular tool for the detection of pathogens.
Sowmya Nagaraj, Shylaja Ramlal, Joseph Kingston, Harsh Vardhan Batra   +3 more
doaj   +2 more sources

Lyophilized Synthetic Platelets: In Vitro Characterization and In Vivo Evaluation in Mouse Thrombocytopenia Model. [PDF]

Adv Sci (Weinh)
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Sekhon UDS, Disharoon D, Desai SS, Traylor B, Gahagan E, Quill E, Aldridge K, Luc NF, Rohiwal S, Raghunathan S, Ahn R, Syed S, Dornback A, Paruchuri BC, Ditto A, Shea SM, Spinella PC, Neal MD, Bruckman MA, Pawlowski CL, Sen Gupta A.   +20 more
europepmc   +2 more sources