Results 11 to 20 of about 1,085 (178)

Lyophilized Synthetic Platelets: In Vitro Characterization and In Vivo Evaluation in Mouse Thrombocytopenia Model. [PDF]

Adv Sci (Weinh)
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Sekhon UDS, Disharoon D, Desai SS, Traylor B, Gahagan E, Quill E, Aldridge K, Luc NF, Rohiwal S, Raghunathan S, Ahn R, Syed S, Dornback A, Paruchuri BC, Ditto A, Shea SM, Spinella PC, Neal MD, Bruckman MA, Pawlowski CL, Sen Gupta A.   +20 more
europepmc   +2 more sources

Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine [PDF]

npj Vaccines, 2023
Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs).
Mingyuan Li, Lin Jia, Yanbo Xie, Wenlin Ma, Zhihong Yan, Fufeng Liu, Jie Deng, Ali Zhu, Xue Siwei, Wen Su, Xiaofeng Liu, Shiqin Li, Haomeng Wang, Peng Yu, Tao Zhu   +14 more
doaj   +3 more sources

Screening and Identification of Triglyceride-Lowering Lactic Acid Bacteria and Preparation of Probiotic Agents. [PDF]

Food Sci Nutr
This study isolated and identified six lactic acid bacteria strains from various fermented foods. Through 16S rRNA sequencing, they were classified as Limosilactobacillus fermentum (PYC02, MHT02, SS01, SC03) and Weissella cibaria (PLHB02, SZ02). Their stress tolerance and safety were evaluated.
Ran X, Hu Q, Wei S, Long H, Luo X, Dong B, Yao Q, Zhu D.   +7 more
europepmc   +2 more sources

Physical Characteristics of Liposomal Formulation Dispersed in HPMC Matrix and Freeze-Dried Using Maltodextrin and Mannitol as Lyoprotectant [PDF]

Pharmaceutical Sciences, 2017
Background: The present study aims to design formulation of liposomes that are well-preserved during freeze-drying. The combination of Hydroxy Propyl Methyl Cellulose (HPMC) as dispersion matrix and lyoprotectants; maltodextrin or mannitol, was employed ...
Raditya Weka Nugraheni 1, Dwi Setyawan 1, Helmy Yusuf 1 *
doaj   +4 more sources

Screening of Superior Lactic Acid Bacteria from Sourdough and Optimization of Freeze-Dried Bacterial Powder Preparation Technology for Steamed Buns [PDF]

Foods
To address the industrialization limitations of traditional sourdough and develop high-performance direct-vat-set (DVS) starters for steamed buns, this study screened superior lactic acid bacteria (LAB) and optimized the preparation technology of freeze ...
Huadi Sun, Lulu Pan, Shunzhi Zhang, Guiting Zhao, Ruixiang Zhao   +4 more
doaj   +2 more sources

Anti-Inflammatory Effects of Lactiplantibacillus plantarum Strain FS4722 Through MAPK and NF-κB Signaling Pathways and Its Lyophilization Optimization [PDF]

Foods
Probiotics hold considerable promise for treating and preventing inflammatory disease; however, their application is often limited by unclear anti-inflammatory mechanisms and reduced viability following lyophilization.
Bista Sunita, Yuxing Liu, Hanwei Zheng, Yue Su, Mingyue Liu, Linfeng Xu, Ikram Alouk, Zhiqing Liu, Wenyong Lou   +8 more
doaj   +2 more sources

Development and Characterization of a Stable Oil-in-Water Nanoemulsion Using Impingement Jet Mixing and Lyophilization Techniques [PDF]

Pharmaceutics
Nanoemulsion (NEM) is an effective adjuvant and delivery system for vaccines and nucleic acids, capable of inducing immune responses against diverse pathogens. Background/Objectives: Conventional NEM manufacture uses multi-step operations, typically high-
Anna Shao, Jingyan Zhang, Zhaowei Jin, Yao Li, Jialin Tang, Quanmin Chen, Hongbing Wu, Jeremy Guo   +7 more
doaj   +2 more sources

Development of a surface tension mediated technique for dry stabilization of mammalian cells. [PDF]

PLoS ONE, 2018
Dry state preservation at ambient temperatures (lyopreservation) is a biomimetic alternative to low temperature stabilization (cryopreservation) of biological materials.
Jason Solocinski, Quinn A Osgood, Eric Rosiek, Lukas Underwood, Oleg Zikanov, Nilay Chakraborty   +5 more
doaj   +2 more sources

A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART) [PDF]

Bioengineering, 2022
Recently, various innovative technologies have been developed for the enhanced delivery of biologics as attractive formulation targets including polymeric micro and nanoparticles.
Niloofar Heshmati Aghda, Yu Zhang, Jiawei Wang, Anqi Lu, Amit Raviraj Pillai, Mohammed Maniruzzaman   +5 more
doaj   +2 more sources

Response Surface Optimization of Lyoprotectant from Amino Acids and Salts for Bifidobacterium Bifidum During Vacuum Freeze-Drying

Acta Universitatis Cibiniensis. Series E: Food Technology, 2017
High quality probiotic powder can lay the foundation for the commercial production of functional dairy products. The freeze-drying method was used for the preservation of microorganisms, having a deleterious effect on the microorganisms viability.
Qi Kangru, Chen He, Wan Hongchang, Hu Man, Wu Yuxi   +4 more
doaj   +3 more sources