Results 131 to 140 of about 32,701 (270)

Viability, Storage Stability, Release Kinetics, and Sensory Attributes of Lactiplantibacillus plantarum ATCC 8014 in Synergistic Cryoprotectant‐Mediated Puree Blend

Applied Research, Volume 5, Issue 5, October 2026.
Synergistic sodium alginate and glycerol protected Lactiplantibacillus plantarum in frozen pumpkin‐carrot purée, maintaining probiotic viability above functional levels for 120 days. The formulation enabled controlled intestinal release, enhanced storage stability, and improved sensory acceptance, supporting its potential as a plant‐based functional ...
Nur Ainaa Nasuha Mustaffa, Siti Fatimah Ibrahim, Noor Azlina Kamaruding, Mohd Al‐Fatihhi Mohd Szali, Shahrulzaman Shaharuddin   +4 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Probing the Structure and Thermoresponsive Behavior of Multicompartment Micelles by Combined Solution‐ and Solid‐State NMR Spectroscopy

Analysis &Sensing, Volume 6, Issue 5, September 2026.
Combined solution‐ and solid‐state NMR spectroscopy is used to probe chain rearrangements in thermoresponsive PNIPAM‐based micelles. We show how core composition affects micellar dynamics and chain mobility across the LCST transition of PNIPAM.
Justyna Żmuda, Ann‐Christin Pöppler
wiley   +1 more source

Hierarchically and Temporally Distinct Ca2+ Signaling Across Thalamic Nuclei During Nociceptive Stimulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Fiber photometry revealed Ca2+ dynamics across multiple thalamic nuclei during nociceptive stimulation. Notably, all recorded thalamic nuclei were activated by nociceptive stimulation. Moreover, medial thalamic nuclei exhibited markedly stronger Ca2+ responses than lateral nuclei, suggesting a medial‐lateral difference in thalamic responses.
Yao‐Hua Liu, Tian‐Yu Zhao, Jin Cheng, Li‐Ming Liu, Sha‐Sha Tao, Yu‐Jing Chen, Jia‐Qi Zhu, Fen‐Sheng Huang, Zhi‐Ping Cai, Fei Li, Yun‐Qing Li   +10 more
wiley   +1 more source

Single‐cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Yixin Ren, Qingyang Zhang, Fanqing Xu, Yao Li, Tianyi Liao, Mengyuan Zhao, Zhiqiang Yan, Xiaohui Zhu, Nan Wang, Peng Yuan, Gary D Smith, Jie Qiao, Jie Yan, Liying Yan, Qilong He   +14 more
wiley   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Biophysical evaluation of aminoclay as an effective protectant for protein stabilization during freeze-drying and storage

International Journal of Nanomedicine, 2016
Jae Geun Song, Sang Hoon Lee, Hyo-Kyung Han College of Pharmacy, Dongguk University, Goyang, South Korea Abstract: This study aimed to evaluate aminoclay (3-aminopropyl-functionalized magnesium phyllosilicate) as an effective protectant for the ...
Song JG, Lee SH, Han HK
doaj  

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Johann Mar Gudbergsson, Pedro Henrique Gobira, Rodrigo Grassi‐Oliveira, Anders Etzerodt   +3 more
wiley   +1 more source

Engineering Piezo1‐Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Cell‐derived extracellular vesicles (EVs) are promising nanocarriers for therapeutic delivery platforms owing to their biocompatibility and capacity to protect and efficiently transport bioactive molecules. However, EV‐based therapeutics remain constrained by inefficient cargo loading and low production yields, which limit scalable ...
Najla A. Saleh, Rozita Shafiq, Amanda P. Cicerone, Sadhana Kilangodi, Hayden Hartwig, George I. Mias, Guangqing Lu, Jun R. Huh, Weiping Li, Cheri X. Deng, Masamitsu Kanada   +10 more
wiley   +1 more source