Results 171 to 180 of about 48,476 (320)

Cryopreservation of the Kidney: A Feasibility Study Based on Cooling Rates

, 2003
This project models the cryopreservation of a kidney submerged in liquid nitrogen. Attempts to cryopreserve whole organs have been unsuccessful in the past due to the formation of ice crystals in the intracellular fluid, which cause damage to the cells.
Malvica, Erica, Salter, Ben, Shauhgnesy, Michael, Verma, Kush, Watkins, Tara   +4 more
core  

Design and characterization of calprotectin tetramerization variants for probing the role of oligomerization in receptor activation

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Calprotectin is a heterodimer of the S100A8 and S100A9 EF‐hand calcium binding proteins, which activates cell surface receptors that signal through the NF‐κB inflammatory signaling pathway. Like all S100 proteins, calcium‐induced conformational changes in calprotectin are required for binding to partner proteins.
Velia Garcia, Areetha D'Souza, Natalia Kozlyuk, Yasiru R. Perera, Steven M. Damo, Walter J. Chazin   +5 more
wiley   +1 more source

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Stephanie Penning, Lachlan Mitchell, Yaoqin Hong, Taylor Cunliffe, Pramod Subedi, Geqing Wang, Lilian Hor, Makrina Totsika, Jason J. Paxman, Begoña Heras   +9 more
wiley   +1 more source

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities

Pest Management Science, Volume 82, Issue 1, Page 151-168, January 2026.
Crystallographic fragment screening of A. thaliana FatA yielded 141 hits and along with orthogonal assays, this enables the target for rapid development of novel chemical matter to the currently available herbicides. Abstract BACKGROUND In order to alleviate the growing issue of herbicide resistance, diversification of the herbicide portfolio is ...
Ekaterina Kot, Matteo Paolo Ferla, Patricia Helen Hollinshead, Charles William Ernest Tomlinson, Daren Fearon, Jasmin Cara Aschenbrenner, Lizbé Koekemoer, Max Winokan, Michael Fairhead, Xiaomin Ni, Rod Chalk, Katherine Sara England, Laura Ortega Varga, Mark Greer Montgomery, Nicholas Phillip Mulholland, Frank von Delft   +15 more
wiley   +1 more source

Bis-prodrug cryopreserved lipid nanoparticles with enzymatically triggered release. [PDF]

Nanoscale Adv
Hogarth C, Arnold K, Elkateb H, Rannard S, McDonald TO.   +4 more
europepmc   +1 more source

DNA‐Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors

Small Science, Volume 6, Issue 1, January 2026.
Biodegradable poly(beta‐amino ester) nanoparticles can be employed to deliver immunostimulatory genes (4‐1BBL and IL‐12) to reprogram brain tumor cells into antigen‐presenting cells to stimulate an anti‐tumor response, resulting in tumor regression and long‐term survival in GBM and meningioma models.
Joanna Yang, Divyaansh Raj, Hasan Slika, Aanya Shahani, Leonardo Cheng, Manav Jain, Ethan Idnani, Kathryn M. Luly, FNU Ruchika, Caitlin Kraft, Charles Eberhart, Henry Brem, Betty Tyler, Jordan J. Green, Stephany Y. Tzeng   +14 more
wiley   +1 more source

Systematic optimization of <i>Caenorhabditis elegans</i> cryopreservation. [PDF]

Biochem Biophys Rep
Agrawal S, Babu KR.
europepmc   +1 more source

PENGARUH KONSENTRASI SUKROSA SEBAGAI CRYOPROTECTANT TERHADAP KARAKTERISTIK SIFAT KIMIA YOGHURT SINBIOTIK KERING BEKU

, 2020
Yunita Yunita, Agustina Intan Niken Tari, Afriyanti Afriyanti   +2 more
openalex   +2 more sources

Mapping Hydration and Nanoarchitecture in mRNA‐Loaded Lipid Nanoparticles Through Small‐Angle Neutron Scattering

Small Structures, Volume 7, Issue 1, January 2026.
Using small‐angle neutron scattering (SANS) with deuterated lipid substitution and contrast variation, this work examines the core–shell structure of KC2 lipid nanoparticles, their water content and exchange properties, structural changes during heating and acidification, and compositional distribution and phase complexity via invariant analysis. These
Haikun Liu, Mark Louis P. Vidallon, Sylvain Trépout, Marina Cagnes, Nageshwar Rao Yepuri, Tamim Darwish, Mitchell J. Moon, Pengkai Shi, Aidan P. G. Walsh, Rico F. Tabor, Karlheinz Peter, Liliana de Campo, Xiaowei Wang   +12 more
wiley   +1 more source

Unraveling Lyophilization and Redispersion Effects on Miktoarm Polymer-Based Nanoformulations. [PDF]

Int J Mol Sci
Yousefi Adlsadabad S, Théberge-Julien G, Gutierrez FFP, Medina RB, Mercado XM, Rhéaume É, Tardif JC, Kakkar A.   +7 more
europepmc   +1 more source