Melanin in the Retinal Epithelium and Magnetic Sensing: A Review of Current Studies
BiophysicaComing in a variety of forms, melanin is one of the most abundant, stable, diverse, and evolutionarily ancient pigments found in living things in nature. These pigments often serve protective functions, typically well-adapted to their specific roles. One
Lidia Zueva +3 more
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DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
eLife, 2015 The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic ...
Stephanie J Papp +7 more
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Localisation of the Putative Magnetoreceptive Protein Cryptochrome 1b in the Retinae of Migratory Birds and Homing Pigeons. [PDF]
PLoS ONE, 2016 Cryptochromes are ubiquitously expressed in various animal tissues including the retina. Some cryptochromes are involved in regulating circadian activity.
Petra Bolte +10 more
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By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, Volume 600, Issue 6, Page 864-893, March 2026.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
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Shedding Light on Animal Cryptochromes
PLoS Biology, 2008 Anyone who's neglected a houseplant for any length of time knows that plants can't survive without light. But it's more complicated than that; in addition to serving as an energy source, light is used by plants as a signal to sense and respond to the environment.
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Scientific ReportsVision and magnetoreception in navigating songbirds are strongly connected as recent findings link a light dependent radical-pair mechanism in cryptochrome proteins to signalling pathways in cone photoreceptor cells. A previous yeast-two-hybrid screening
Chad Yee +6 more
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Circadian light-input pathways in Drosophila
Communicative & Integrative Biology, 2016 Light is the most important environmental cue to entrain the circadian clock in most animals. In the fruit fly Drosophila melanogaster, the light entrainment mechanisms of the clock have been well-studied.
Taishi Yoshii +2 more
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Photoreceptor cross-talk in UV-B photomorphogenesis in tomato (Solanum lycopersicum) : screening through phytochrome and cryptochrome mutants : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology at Massey University, Palmerston North, New Zealand [PDF]
, 2017 Figures 1.1, 1.3, 1.4 and 1.5 removed due to copyright reasonsPlant photoreceptors detect changes in the light environment and induce differential gene expression, resulting in the appropriate physiological and morphological responses.
Pabellon, Ivie V S
core
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, Volume 600, Issue 6, Page 837-846, March 2026.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Avian cryptochrome 4 binds superoxide
Computational and Structural Biotechnology JournalFlavin-binding cryptochromes are blue-light sensitive photoreceptors that have been implicated with magnetoreception in some species. The photocycle involves an intra-protein photo-reduction of the flavin cofactor, generating a magnetosensitive radical pair, and its subsequent re-oxidation.
Jean Deviers +3 more
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