Results 71 to 80 of about 14,383 (270)

Dimerisation of European robin cryptochrome 4a

The Journal of Physical Chemistry B, 2023
AbstractHomo-dimer formation is important for the function of many proteins. Although dimeric forms of cryptochromes (Cry) have been found by crystallography and were recently observedin vitrofor European robin Cry4a, little is known about the dimerisation of avian cryptochromes and the role it could play in the mechanism of magnetic sensing in ...
Maja Hanić, Lewis M. Antill, Angela S. Gehrckens, Jessica Schmidt, Katharina Görtemaker, Rabea Bartölke, Tarick J. El-Baba, Jingjing Xu, Karl W. Koch, Henrik Mouritsen, Justin L. P. Benesch, P. J. Hore, Ilia A. Solov’yov   +12 more
openaire   +3 more sources

Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms of Drosophila melanogaster

Clocks & Sleep, 2021
Chronobiotics are a group of drugs, which are utilized to modify circadian rhythms targeting clock-associated molecular mechanisms. The circadian clock is known as a controller of numerous processes in connection with aging.
Ilya A. Solovev, Mikhail V. Shaposhnikov, Alexey A. Moskalev   +2 more
doaj   +1 more source

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Seasonal migration is dependent on an organism being able to sense and reorient to the Earth’s magnetic field. Cryptochromes (CRYs) have been implicated as light-driven sensors of the Earth’s magnetic field; however, contradictions between ...
B. Zoltowski, Y. Chelliah, A. Wickramaratne, Lauren E. Jarocha, Nischal Karki, Wei Xu, H. Mouritsen, P. Hore, R. Hibbs, C. Green, J. Takahashi   +10 more
semanticscholar   +1 more source

Suppression of Rice Cryptochrome 1b Decreases Both Melatonin and Expression of Brassinosteroid Biosynthetic Genes Resulting in Salt Tolerance

Molecules, 2021
We investigated the relationship between the blue-light photoreceptor cryptochrome (CRY) and melatonin biosynthesis by generating RNA interference (RNAi) transgenic rice plants that suppress the cryptochrome 1b gene (CRY1b). The resulting CRY1b RNAi rice
Ok-Jin Hwang, K. Back
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Cryptochromes Mediate Intrinsic Photomechanical Transduction in Avian Iris and Somatic Striated Muscle

Frontiers in Physiology, 2020
Irises isolated from the eyes of diverse species constrict when exposed to light. Depending on species this intrinsic photomechanical transduction response (PMTR) requires either melanopsin or cryptochrome (CRY) photopigment proteins, generated by their ...
Joseph F. Margiotta, Marthe J. Howard
doaj   +1 more source

Importance of Polarizable Embedding for Absorption Spectrum Calculations of Arabidopsis thaliana Cryptochrome 1

Journal of Physical Chemistry B
Cryptochromes are essential flavoproteins for circadian rhythms and avian magnetoreception. Flavin adenine dinucleotide (FAD), a chromophore within cryptochromes, absorbs blue light, initiating electron transfer processes that lead to a biological ...
Anders Frederiksen, L. Gerhards, Peter Reinholdt, Jacob Kongsted, I. Solov’yov   +4 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Cryptochrome Blue Light Receptors [PDF]

The Arabidopsis Book, 2010
Cryptochromes are photolyase-like blue light receptors originally discovered in Arabidopsis but later found in other plants, microbes, and animals. Arabidopsis has two cryptochromes, CRY1 and CRY2, which mediate primarily blue light inhibition of hypocotyl elongation and photoperiodic control of floral initiation, respectively.
Xuhong, Yu, Hongtao, Liu, John, Klejnot, Chentao, Lin   +3 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source