5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus [PDF]
Nature Communications, 2020 Patients infected with the fungal pathogen Cryptococcus are most effectively treated with a combination of 5-fluorocytosine (5FC) and amphotericin B. 5FC acts as a prodrug, which is converted into toxic 5-fluorouracil (5FU) upon uptake into fungal cells.
Billmyre, R. Blake +4 more
core +3 more sources
Cryptococcus extracellular vesicles properties and their use as vaccine platforms
Journal of Extracellular Vesicles, 2021 Whereas extracellular vesicle (EV) research has become commonplace in different biomedical fields, this field of research is still in its infancy in mycology.
Juliana Rizzo +16 more
doaj +2 more sources
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance [PDF]
mBio, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
William Hope +14 more
doaj +3 more sources
Vaccination with recombinant Cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and cryptococcal species [PDF]
mBio, 2017 Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated with crude ...
et al,, Lodge, Jennifer K
core +3 more sources
Oftalmoplejía internuclear bilateral como rara presentación inicial de meningitis criptocócica [PDF]
Revista de la Facultad de Ciencias Médicas de CórdobaIntroducción. La meningitis criptocócica (MC) se asocia frecuentemente a pacientes inmunocomprometidos, específicamente en infección por VIH, con una alta mortalidad.
Raymundo Solís-Gómez +4 more
doaj +2 more sources
Opportunistic Fungal Infections in Immunocompromised Patients of a Tertiary Care Centre, Amritsar, India [PDF]
National Journal of Laboratory Medicine, 2022 Introduction: The incidence of opportunistic fungal infections has increased considerably in recent years. The clinical manifestations of these infections are non specific, and laboratory methods generally cannot diagnose infection at an initial ...
PAVNEET KAUR +2 more
doaj +1 more source
Direct Inhibition of T-Cell Responses by the Cryptococcus Capsular Polysaccharide Glucuronoxylomannan [PDF]
, 2006 The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high-molecular-weight polysaccharide that is shed during cryptococcosis and can ...
Lam, Jennifer S +2 more
core +12 more sources
Cryptococcus neoformans, a global threat to human health
Infectious Diseases of Poverty, 2023 Background Emerging fungal pathogens pose important threats to global public health. The World Health Organization has responded to the rising threat of traditionally neglected fungal infections by developing a Fungal Priority Pathogens List (FPPL ...
Youbao Zhao +14 more
semanticscholar +1 more source
Indian Journal of Transplantation, 2022 Cryptococcosis is the most common invasive fungal infection to involve the central nervous system in the posttransplant period. Cryptococcal meningitis, which constitutes disseminated cryptococcosis, can present with nonspecific signs and symptoms ...
Sandhya Suresh +2 more
doaj +1 more source
Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection
Frontiers in Cellular and Infection Microbiology, 2022 Macrophages are key cellular components of innate immunity, acting as the first line of defense against pathogens to modulate homeostatic and inflammatory responses.
Yan Wang +5 more
semanticscholar +1 more source