Results 31 to 40 of about 58,986 (239)

Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa [PDF]

, 2015
This work was supported by Wellcome Trust (UK) (www.wellcome.ac.uk) awards to TB (WT069991), GM (WT098316), and JNJ (WT081794); Medical Research Council (MRC UK) (www.mrc.ac.uk) awards to MCF (K000373/1), RCM (G0601171), TSH (G1002327); European Research
Fisher, Matthew C, Matthew C Fisher, Matthew C. Fisher (129755), Angela Loyse (292490), Meintjes, Graeme, Fisher, Matthew C., Emma J. Robertson (760738), Sabiiti, Wilber, O'Hanlon, SJ, O'Hanlon, Simon J, Joseph N Jarvis, Tihana Bicanic (718812), Thomas S. Harrison (222993), Fisher, MC, Karen M Fuentes-Cabrejo, Fuentes-Cabrejo, KM, Fuentes-Cabrejo, Karen M, Angela Loyse, Fisher, M, Harrison, Thomas S, Harrison, TS, Robertson, EJ, Simon J. O’Hanlon (760740), Loyse, Angela, Meintjes, G, Simon J O'Hanlon, Robin C May, Jarvis, Joseph N, Emma J Robertson, Wilber Sabiiti (170648), Thomas S Harrison, Mathew A. Beale (663616), Wilber Sabiiti, Robertson, Emma J, Joseph N. Jarvis (435279), Robertson, Emma J., Jarvis, JN, May, Robin C, Mathew A Beale, Karen M. Fuentes-Cabrejo (760739), Graeme Meintjes (221054), Beale, Mathew A, Tihana Bicanic, Sabiiti, W, Bicanic, T, May, RC, Loyse, A, May, Robin C; id_orcid, Bicanic, Tihana, Graeme Meintjes, Beale, MA, Robin C. May (170650)   +51 more
core   +1 more source

Lenalidomide Improves Cognitive Function and Reduces Immune Reconstitution Inflammatory Syndrome in HIV-1-Related Cryptococcal Meningitis

Journal of Inflammation Research, 2022
Ran Tao,1 Xiaorong Peng,1 Xiang Liu,1 Junwei Su,1 Guanjing Lang,1 Ying Huang,1 Yafei Zhang,2 Biao Zhu1 1The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for ...
Tao R, Peng X, Liu X, Su J, Lang G, Huang Y, Zhang Y, Zhu B   +7 more
doaj  

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, EarlyView.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +2 more sources

Capsule-deficient cryptococcal meningitis: A diagnostic conundrum

Journal of Global Infectious Diseases, 2022
Cryptococcosis is a serious systemic mycosis. Its incidence has escalated in the past four decades. Cryptococcus neoformans causes localized or disseminated infection in immunocompromised and immunocompetent patients.
Trupti Shende, Gagandeep Singh, Immaculata Xess, Swati Khullar, Renu Kumari Yadav, Reshu Agarwal, M Vasantha Padma Srivastava   +6 more
doaj   +1 more source

Butterfly lesion on MRI: Cryptococcus meningoencephalitis with unusual imaging in a patient with AIDS

Clinical Case Reports, 2021
In immunocompromised patients, including patients with AIDS, with neurologic complaints, we propose including Cryptococcus meningoencephalitis in the differential diagnoses when the butterfly pattern is encountered on MRI.
Mary Henary, Jennifer Oster, Antonio Liu
doaj   +1 more source

Cryptococcus

Current Biology
Fungal pathogens pose a significant threat to human health that is greatly underrecognized, despite causing several million deaths every year. To put it simply, the fight against these fungi is complicated. At baseline, there is a severe lack of effective and accessible antifungals, especially in regions with limited resources.
Briner, Sydney L., Doering, Tamara L.
openaire   +2 more sources

Cryptococcus neoformans and Cryptococcus gattii, the Etiologic Agents of Cryptococcosis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished from other pathogenic yeasts such as Candida by the presence of a polysaccharide capsule, formation of melanin, and urease activity, which all function as virulence determinants ...
Kwon-Chung, Kyung J., Fraser, James A., Doering, Tamara L., Wang, Zhuo A., Janbon, Guilhem, Idnurm, Alexander, Bahn, Yong-Sun   +6 more
openaire   +5 more sources

Characteristics and Outcomes of Cryptococcosis among Patients with and without COVID-19

Journal of Fungi, 2022
The effect of COVID-19 on the risk and prognosis of cryptococcosis is unclear. We compared the characteristics and outcomes of cryptococcosis in patients with and without COVID-19.
Daniel B. Chastain, Vanessa M. Kung, Lilian Vargas Barahona, Brittany T. Jackson, Sahand Golpayegany, Carlos Franco-Paredes, George R. Thompson, Andrés F. Henao-Martínez   +7 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source