Results 51 to 60 of about 30,730 (271)

Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility

Frontiers in Endocrinology, 2018
Nonsyndromic cryptorchidism is a common multifactorial, condition with long-term risks of subfertility and testicular cancer. Revealing the causes of cryptorchidism will likely improve prediction and prevention of adverse outcomes.
Julia S. Barthold, Richard Ivell
doaj   +1 more source

RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism

Frontiers in Endocrinology, 2023
IntroductionThe fertility of cryptorchidism patients who didn’t perform corrective surgery will decrease with age. Herein, we elucidate the histological alterations and underlying molecular mechanism in patients with an increase in the disease duration ...
Weihao Sun, Xinhui Zhang, Lei Wang, Guanyu Ren, Shuguang Piao, Chenghua Yang, Chenghua Yang, Zhiyong Liu, Zhiyong Liu   +8 more
doaj   +1 more source

Male reproductive health and environmental xenoestrogens [PDF]

, 1996
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or ...
A Giwercman, Ansell PE, Avellan L, B Jégou, Baird DD, Baumrucker GO, Berkowitz GD, Berkowitz GS, Bibbo M, Bigler WJ, Bj N, Blom K, Bostofte E, Bradbury RB, Bromage NR, Brown LM, Buemann B, Campbell DM, Cassidy A, Chung CS, Clemens MJ, Conover MR, Copeland PA, Czeizel A, Depue RH, Driscoll SG, E Rajpert-De Meyts, Forman D, Fox GA, Freeman HC, Frst P, Fry DM, Gray LEJ, Gray LEJ, Greco TL, H Leffers, Hakulinen T, Halevi HS, Harris LE, Hautau ER, Henderson BE, Hirasing RA, Hohlbein R, Hsieh J-T, Ikeda Y, J A McLachlan, J C Larsen, J Müller, J Sumpter, J Toppari, Jennings ML, Jost A, Kallen B, Kallen B, Korach KS, Kupfer D, L J Guillette, Leatherland JF, Leatherland JF, McDonnell DP, McIntosh R, N E Skakkebaek, N Keiding, Newbold RR, O Meyer, P Christiansen, P Grandjean, P Jouannet, Panayotou PC, Pearce N, Peterson RE, Pohjanvirta R, R Sharpe, Rey RA, Schumacher GFB, Scully RE, Sell S, Soto AM, Sweet RA, T K Jensen, T Scheike, Thomas KB, Thomas KB, Thorup J, Tryphonas L, Turscott B, Vessey MP, Wallace HM, Ward B, Wilkinson TJ   +89 more
core   +2 more sources

Noonan Syndrome Spectrum Disorders Predispose to Systemic Lupus Erythematosus: Case Report and Critical Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT RASopathies are clinically overlapping neurodevelopmental syndromes resulting from germline mutations in genes involved in the rat sarcoma/mitogen‐activated protein kinases (RAS/MAPK) pathway. Historically, RASopathies have been described by clinical phenotypes, such as Noonan syndrome and Neurofibromatosis type I.
Anastasia‐Vasiliki Madenidou, Gillian I. Rice, James O'Sullivan, Ben Parker, Ian N. Bruce, Emma Burkitt‐Wright, Tracy A. Briggs   +6 more
wiley   +1 more source

The Nature of Disorders in Reproductive System in Unilateral Cryptorchidism [PDF]

Саратовский научно-медицинский журнал, 2009
The objective of the research: assessment of the condition of the reproductive system in patients with unilateral cryptorchidism. Children and teenage boys with unilateral cryptorchidism before surgical treatment, young adult men with surgically treated ...
E.S. Pimenova
doaj  

Weak association of anti-sperm antibodies and strong association of familial cryptorchidism/infertility with HLA-DRB1polymorphisms in prepubertal Ukrainian boys

Reproductive Biology and Endocrinology, 2011
Background Cryptorchidism is a frequent syndrome occurring in 1-2% of males within the first year of age. Autoimmune reactions, particularly directed to testicular elements and/or spermatozoa have been found to be often associated with cryptorchidism ...
Chopyak Valentyna, Nowakowska Beata, Kamieniczna Marzena, Havrylyuk Anna, Niepieklo-Miniewska Wanda, Nakonechnyy Andriy, Kurpisz Maciej, Kusnierczyk Piotr   +7 more
doaj   +1 more source

Neuropathic Pain and Enlarged Nerves in Adult Noonan Syndrome and Noonan Syndrome With Multiple Lentigines: Health‐Related Quality of Life and Neurologic Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome (NS) and the clinically related Noonan syndrome with multiple lentigines (NSML) belong to the group of RASopathies. Although pain is not mentioned as a characteristic feature, it has recently been reported as a clinically significant problem.
Jos M. T. Draaisma, Wesley Reintjes, Erika Leenders, Fieke Draaisma, Melanie Burgers, Lotte Kleimeier, Marco Tartaglia, Merel Klaassens, Ruud Becks, Steven Renes, Ellen Wingbermühle, Nicol C. Voermans, Nens van Alfen   +12 more
wiley   +1 more source

Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling

Cell Reports Medicine
Summary: Cryptorchidism, commonly known as undescended testis, affects 1%–9% of male newborns, posing infertility and testis tumor risks. Despite its prevalence, the detailed pathophysiology underlying male infertility within cryptorchidism remains ...
Xiaoyan Wang, Qiang Liu, Ziyan Zhuang, Jianxing Cheng, Wenxiu Zhang, Qiaoling Jiang, Yifei Guo, Ran Li, Xiaojian Lu, Lina Cui, Jiaming Weng, Yanlin Tang, Jingwei Yue, Songzhan Gao, Kai Hong, Jie Qiao, Hui Jiang, Jingtao Guo, Zhe Zhang   +18 more
doaj   +1 more source

Stable variable selection for right censored data: comparison of methods [PDF]

, 2011
The instability in the selection of models is a major concern with data sets containing a large number of covariates. This paper deals with variable selection methodology in the case of high-dimensional problems where the response variable can be right ...
Besse, Philippe, Leconte, Eve, Walschaerts, Marie   +2 more
core   +3 more sources

Electro‐clinical features of Mowat–Wilson syndrome: A retrospective study of 31 children in mainland China

Epileptic Disorders, EarlyView.
Abstract Objective To summarize the electro‐clinical and genetic characteristics of children with Mowat–Wilson syndrome (MWS). Methods This study is a hospital‐based case series analyzing clinical data from 31 pediatric patients with MWS and epilepsy treated at Peking University First Hospital between June 2020 and December 2024.
Yi Ju, Tao‐yun Ji
wiley   +1 more source