Results 71 to 80 of about 32,335 (282)

miR-34c disrupts spermatogonial stem cell homeostasis in cryptorchid testes by targeting Nanos2

Reproductive Biology and Endocrinology, 2018
Background Cryptorchidism as a common genitourinary malformation with the serious complication of male infertility draws widespread attention. With several reported miRNAs playing critical roles in spermatogonial stem cells (SSCs), we aimed to explore ...
Zhenyu Huang, Dongdong Tang, Jingjing Gao, Xianming Dou, Peng Cheng, Dangwei Peng, Yao Zhang, Jun Mao, Li Zhang, Xiansheng Zhang   +9 more
doaj   +1 more source

Is the right testis more affected by cryptorchidism than the left testis? An ultrasonographic approach in dogs of different sizes and breeds.

Folia Morphologica, 2019
Considered the most common congenital testicular abnormality of companion animals and a predisposition factor to the development of testicular neoplasia, cryptorchidism is defined as the non-descent of one or both testes to their normal anatomical ...
V. G. S. Tannouz, M. Mamprim, M. Lopes, C. A. Santos-Sousa, P. Souza, M. Babinski, M. Abidu-Figueiredo   +6 more
semanticscholar   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

Transscrotal transverse incision for the treatment of middle and low cryptorchidism in children: experience from 796 cases

BMC Surgery, 2020
Background The purpose of this study was to summarize our clinical experience with transscrotal transverse incision in the treatment of low and middle cryptorchidism in children.
Yun-jin Wang, Liu Chen, Qi-liang Zhang, Yu Lin, Xu Cui, Jian-cai Chen, Chao-ming Zhou   +6 more
doaj   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

Testicular neoplasia in undescended testes of cryptorchid boys-does surgical strategy have an impact on the risk of invasive testicular neoplasia?

The Turkish Journal of Pediatrics, 2004
We investigated whether or not surgical strategy has an impact on the risk of invasive testicular neoplasia in cases of cryptorchidism. We made a database study of the incidence of testicular neoplasia at surgery for cryptorchidism in childhood ...
Dina Cortes, Jorgen Thorup, Bodil Laub Petersen   +2 more
doaj  

A Case–Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations

Environmental Health Perspectives, 2017
Background: Polybrominated diphenyl ethers (PBDEs) are flame retardants found in North American household products during the past four decades. These chemicals leach out in dust as products age, exposing individuals daily through inhalation and ...
C. Goodyer, S. Poon, K. Aleksa, Laura Hou, Veronica Atehortua, A. Carnevale, G. Koren, R. Jednak, S. Emil, D. Bagli, S. Dave, B. Hales, J. Chevrier   +12 more
semanticscholar   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Molecular Mechanisms of Syndromic Cryptorchidism: Data Synthesis of 50 Studies and Visualization of Gene-Disease Network

Frontiers in Endocrinology, 2018
Background: Cryptorchidism is one of the most frequent congenital birth defects in male children and is present in 2–4% of full-term male births. It has several possible health effects including reduced fertility, increased risk for testicular neoplasia,
Kristian Urh, Živa Kolenc, Maj Hrovat, Luka Svet, Peter Dovč, Tanja Kunej   +5 more
doaj   +1 more source

Role of ADAMTS16 metalloproteinase in pathogenesis of cryptorchidism

Archives of Medical Science, 2020
Introduction The etiology of cryptorchidism is still not fully elucidated, but several hypotheses have been proposed. One of the latest concerns is the involvement of metalloproteinase ADAMTS16 in testis descent.
Joanna Gerszon, Jacek Kabziński, Piotr Kucharski, Ireneusz Majsterek, Jerzy K. Niedzielski   +4 more
doaj   +1 more source