Results 81 to 90 of about 25,988 (233)

Bioinformatic identification of key genes and molecular pathways in the spermatogenic process of cryptorchidism

Genes and Diseases, 2019
This study aims to determine key genes and pathways that could play important roles in the spermatogenic process of patients with cryptorchidism. The gene expression profile data of GSE25518 was obtained from the Gene Expression Omnibus (GEO) database ...
Yu Zhou, Deying Zhang, Bo Liu, Dong Hu, Lianju Shen, Chunlan Long, Yihang Yu, Tao Lin, Xing Liu, Dawei He, Guanghui Wei   +10 more
doaj   +1 more source

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, EarlyView.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

Pattern and risk factors of cryptorchidism in Gorgan, northern Iran

مجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Cryptorchidism or undescending testis is a developmental defect and occurred in 2-4% of male newborns. This study was done to determine the pattern and risk factors of cryptorchidism in Gorgan, northern Iran.
Mirfazeli A, Kavianyn N, Vakili MA, Tajari HA, Golalipour MJ   +4 more
doaj  

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

Stable variable selection for right censored data: comparison of methods [PDF]

, 2011
The instability in the selection of models is a major concern with data sets containing a large number of covariates. This paper deals with variable selection methodology in the case of high-dimensional problems where the response variable can be right ...
Besse, Philippe, Leconte, Eve, Walschaerts, Marie   +2 more
core   +3 more sources

De novo variants disturbing the transactivation capacity of POU3F3 cause a characteristic neurodevelopmental disorder

, 2019
POU3F3, also referred to as Brain-1, is a well-known transcription factor involved in the development of the central nervous system, but it has not previously been associated with a neurodevelopmental disorder.
Au, C., Baker, S., Bergstrom, K., Bodek, S., Brunner, H., Cunniff, C., Dentici, M., Derizioti, P., Faivre, L., Firth, H., Fisher, S., Gilissen, C., Iglesias, A., Izumi, K., Kleefstra, T., Kroes, H., Lachmeijer, A., Leonard, J., Maas, S., Matsumoto, N., Miyake, N., Niceta, M., Okamoto, N., Pfundt, R., Philippe, C., Powis, Z., Shinde, D., Snijders Blok, L., Tang, S., Tartaglia, M., Tayoun, A., Tomkins, S., Van Gassen, K., Venselaar, H., Vitobello, A., Wiel, L., Wojcik, M., Õunap, K.   +37 more
core   +1 more source

Analgesic use in pregnancy and male reproductive development [PDF]

, 2017
PURPOSE OF REVIEW: Male reproductive disorders are common and increasing in incidence in many countries. Environmental factors (including pharmaceuticals) have been implicated in the development of these disorders.
Axelstad, Berkowitz, Bonde, Correy, Dean, Dean, Fowler, Gabrielsen, Gupta, Hernandez, Holm, Holm, Hsieh, Hughes, Jensen, Kristensen, Kristensen, Kristensen, Lind, Lind, Mazaud-Guittot, Mitchell, Naga Rani, Nef, Niedzielski, Nitsche, Philippat, Radmayr, Sepúlveda, Skakkebaek, Skakkebæk, Slone, Snijder, Springer, Thankamony, van den Driesche, Weigand, Welsh, Werler   +38 more
core   +1 more source

Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Aksh Tailor, Oishee Bandyopadhyay, Nahian Ahmed, Kapishan Shanmugathasan, Alice Cotton, ChingHao Chen, Tet Yap   +6 more
wiley   +1 more source

Caveolin 1 Regulates the Tight Junctions between Sertoli Cells and Promotes the Integrity of Blood–Testis Barrier in Yak via the FAK/ERK Signaling Pathway

Animals
Yaks, a valuable livestock species endemic to China’s Tibetan plateau, have a low reproductive rate. Cryptorchidism is believed to be one of the leading causes of infertility in male yaks. In this study, we compared the morphology of the normal testis of
Qiu Yan, Tianan Li, Yong Zhang, Xingxu Zhao, Qi Wang, Ligang Yuan   +5 more
doaj   +1 more source

Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation

Laboratory Animal Research, 2016
Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model preparation is important for the characterization
Won-Young Lee, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jiyun Ahn, Hyunjhung Jhun   +6 more
doaj   +1 more source