Results 41 to 50 of about 5,245 (194)

Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway

Frontiers in Neuroscience, 2019
Cryptotanshinone (CTN), a monomer compound extracted from the dried roots and rhizomes of Salvia miltiorrhiza Bge, has a variety of pharmacological effects.
Yang Zhou, Yang Zhou, Yang Zhou, Xiao Wang, Weihai Ying, Danhong Wu, Ping Zhong   +6 more
doaj   +1 more source

Identification of c-Met on Tumor Cells as a Novel Receptor for B7-H3 Entails Implications for Cancer Cell Stemness and Targeted Therapy. [PDF]

MedComm (2020)
B7‐H3 and c‐Met interaction is revealed to be crucial in maintaining cancer cell stemness primarily via c‐Met/STAT3 signaling pathway. B7‐H3 antibody blocking this newly identified interaction exhibits preclinical effects as a new and potent intervention for molecular targeted therapy.
Cao L, Xu Y, Hu Y, Huang X, Fu F, Zhan S, Huang L, Feng Y, Irene Y, Li H, Markku V, Jorma KO, Zhang G, Lu B, Wang J, Liu W, Zhang X.   +16 more
europepmc   +2 more sources

Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Frontiers in Pharmacology, 2022
Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis.
Xiaomeng Guo, Ruishuang Ma, Meng Wang, Benson Wui-Man Lau, Xiaopeng Chen, Yue Li   +5 more
doaj   +1 more source

Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish

Frontiers in Pharmacology, 2021
Thrombosis is a key pathological event in cardiovascular diseases, and is also the most important targeting process for their clinical management. New drug development in thrombosis treatment is still in great demand. According to the traditional Chinese
Jun Li, Hao Liu, Zhenzhong Yang, Qingqing Yu, Lu Zhao, Yi Wang, Yi Wang   +6 more
doaj   +1 more source

Non Communicable Diseases and Infections Refuse to go away Despite Current Knowledge and Scientific Advances. [PDF]

, 2014
No abstract ...
Tumwine, James K
core   +2 more sources

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs)

Pharmaceutical Biology, 2017
Contents: Danshen is a popular herb employed to treat cardiovascular and cerebrovascular diseases worldwide. Danshen–drug interaction has not been well studied.
Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang   +4 more
doaj   +1 more source

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit

Frontiers in Neurology, 2019
Cryptotanshinone (CTs), an active component isolated from the root of Salvia miltiorrhiza (SM), has been shown to exert potent neuroprotective property.
Hongye Zhao, Hongye Zhao, Tiezheng Zheng, Xiaohan Yang, Ming Fan, Lingling Zhu, Shuhong Liu, Liying Wu, Changkai Sun, Changkai Sun   +9 more
doaj   +1 more source

Cryptotanshinone increases the sensitivity of liver cancer to sorafenib by inhibiting the STAT3/Snail/epithelial mesenchymal transition pathway

Frigid Zone Medicine, 2022
Sorafenib resistance has been a major factor limiting its clinical use as a targeted drug in liver cancer. The present study aimed to investigate whether cryptotanshinone can enhance the sensitivity of liver cancer and reduce the resistance to sorafenib.
Li Zhiyu, Chen Kegong, Cui Chao, Wang Yinghui, Wu Dequan   +4 more
doaj   +1 more source

Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy

Molecules, 2020
Salvia mltiorrhiza Bunge (SMB) is native to China, whose dried root has been used as medicine. A few chromatographic- or spectrometric-based methods have already been used to analyze the lipid-soluble components in SMB.
Yuanyuan Li, Zhuoni Hou, Feng Su, Jipeng Chen, Xiaodan Zhang, Ling Xu, Dongfeng Yang, Zongsuo Liang   +7 more
doaj   +1 more source

Combining Metabolomics and Transcriptomics to Characterize Tanshinone Biosynthesis in Salvia Miltiorrhiza [PDF]

, 2014
Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access ...
Cui, Guanghong, Gao, Wei, Hillwig, Matthew L, Huang, Luqi, Jackson, Alana, Peters, Reuben J, Shen, Ye, Sun, Hai-Xi, Wang, Xiao, Wang, Xiu-Jie, Xiao, Hongbin, Zhang, Liangxiao, Zhao, Nan   +12 more
core   +3 more sources