Results 71 to 80 of about 5,245 (194)

WuYeLuGen Granule Attenuates Bleomycin‐Induced Pulmonary Fibrosis in Rats by Inhibiting the TGF‐β1/Smad Signaling Pathway and Epithelial–Mesenchymal Transition

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Background Pulmonary fibrosis is a chronic disease characterized by progressive interstitial lung changes affecting alveolar epithelial cells and pulmonary vessels. Following COVID‐19, it has emerged as a significant sequela in severe cases, often with a poor prognosis.
Jia-Wei Zeng, Li Lin, Yan-Jun Duan, Lipi Buch   +3 more
wiley   +1 more source

Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury [PDF]

, 2006
Lipopolysaccharide (LPS) has been implicated as one of the major cause of Gram-negative bacteria-induced sepsis that are life-threatening syndromes occurring in intensive care unit patients. Many natural products derived from medicinal plants may contain
Chan, DKO, Fu, KHM, Lee, CL, Sit, WH, Wan, JMF   +4 more
core   +1 more source

Methylation Landscapes of Cartilage in Hip Osteoarthritis

Genetics Research , Volume 2026, Issue 1, 2026.
Objective To elucidate different methylation landscapes between cartilage of femoral neck fracture and preserved and damaged cartilages in hip osteoarthritis (OA). Methods Genome‐wide DNA methylation data were acquired from two data sets in GEO database (GSE63106 and GSE63695), which were based on Illumina HumanMethylation450 BeadChip arrays.
Ruiyang Jiang, Maochun Wang, Guihua Tan, Jie Lv, Xiaoyu Jin, Yuan Liu, Rui Wu, Dongquan Shi, Yingkun Xu   +8 more
wiley   +1 more source

Effect of Plant Density on Growth and Bioactive Compounds in Salvia miltiorrhiza

Agronomy
Danshen (Salvia miltiorrhiza) is an herbaceous plant widely used in the pharmaceutical industry. However, the majority of medicinal plants utilized in the US are imported, posing challenges such as fluctuations in bioactive compound concentrations and ...
Zhiheng Xing, Guihong Bi, Tongyin Li, Qianwen Zhang, Patricia R. Knight   +4 more
doaj   +1 more source

Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2 [PDF]

, 2016
Putative functions of the heterotrimeric G-protein subunit Gαi2-dependent signaling include ion channel regulation, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Chen, Hong, Fakhri, Hajar, Fehrenbacher, Birgit, Ghashghaeinia, Mehrdad, Honisch, Sabina, Lang, Elisabeth, Lang, Florian, Liu, Guilai, Liu, Guoxing, Lupescu, Adrian, Mack, Andreas F., Qadri, Syed M., Rexhepaj, Rexhep, Schaller, Martin, Singh, Yogesh, Umbach, Anja T., Zelenak, Christine   +18 more
core   +2 more sources

Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone

Biochemical and Biophysical Research Communications
Neovascular eye diseases, including proliferative diabetic retinopathy and retinopathy of prematurity, is a major cause of blindness. Laser ablation and intravitreal anti-VEGF injection have shown their limitations in treatment of retinal neovascularization. Identification of a new therapeutic strategies is in urgent need.
Yang, Yu, Xun, Qin, Xi, Chen, Huiling, Nie, Juxue, Li, Jin, Yao   +5 more
openaire   +2 more sources

Icariin Alleviates Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Modulating the Gut–Lung Axis and Serum Metabolism

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of uncertain etiology with few specific and effective therapeutic agents approved for its treatment. We examined the underlying processes and the impact of icariin (ICA) on a bleomycin‐induced pulmonary fibrosis model.
Ting Zhang, Weiyi Gong, Cheng Huang, Hongkai Wang, Baojun Liu, Dawei Cui   +5 more
wiley   +1 more source

Cryptotanshinone Inhibits Bladder Cancer Cell Malignant Progression in a Lipopolysaccharide-Induced Inflammatory Microenvironment through NLRP3 Inhibition

Mediators of Inflammation
Background. Bladder cancer (BC) is one of the most common malignancies of the urogenital system. This study assessed the nucleotide-binding oligomerization domain and leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) in BC as well as the ...
Chenye Tang, Xiao Guo, Yu Li, Yongxiang Yi, Zhiling Tang, Qihui Zhang, Bairu Luo, Kean Chen, Ke Liang, Gang Li   +9 more
doaj   +1 more source

Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis

Molecular Therapy: Nucleic Acids, 2018
Cryptotanshinone (CTS) has emerged as an anti-inflammatory agent in osteoarthritis (OA). However, the molecular mechanism underlying its potent therapeutic effect on OA remains largely unknown.
Quanbo Ji, Dengbin Qi, Xiaojie Xu, Yameng Xu, Stuart B. Goodman, Lei Kang, Qi Song, Zhongyi Fan, William J. Maloney, Yan Wang   +9 more
doaj   +1 more source

Aldose Reductase Inhibitory Activity of Chinese Crude Drug "Danshen" [PDF]

, 2000
漢薬“丹参”の基源植物である丹参（Salvia miltiorhiza）及び中国新彊において丹参（S.miltiorhiza）の代用品として用いられている新彊丹参（S.deserta）のアルドース還元酵素阻害活性成分を調べたところ，両者の活性成分は全く異なっていた。さらに，丹参（S.miltiorhiza）の代用品として用いられている10種を含む17種類のSalvia属植物について，水およびメタノールエキスのアルドース還元酵素阻害活性およびLC-MS分析を比較した結果も ...
手塚 康弘, 門田 重利
core   +1 more source