Results 91 to 100 of about 839,348 (339)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Optomechanical many-body cooling using frustration

, 2016
We show that the vibrations of an ion Coulomb crystal can be cooled to the zero-point motion through the optomechanical coupling with a high-finesse cavity.
Cormick, Cecilia, Fogarty, Thomás, Landa, Haggai, Morigi, Giovanna   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effects of normal and oblique incidence on zero-n gap in periodic lossy multilayer containing double-negative materials

, 2012
In this paper the transmission of electromagnetic waves through a one-dimensional lossy photonic crystal consisting of layers with negative and positive refractive indices is investigated.
Aghajamali, Alireza, Barati, Mahmood
core   +1 more source

Surface Photonic Crystal Engineering of a Multi-Mode VCSEL for a Bit-Loaded Broadband QAM-OFDM Data Link at 99 Gbit/s [PDF]

, 2023
Yuhong Lin, Chih‐Hsien Cheng, C.S. Tsai, Wei-Li Wu, Kent D. Choquette, Gong‐Ru Lin   +5 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Reversible conductivity modulation by tuning surface band bending in Sn-doped β-Ga2O3 single crystal

APL Materials
Developing methods for modulating the band structure of semiconductor material is crucial for the application. In this work, the electron concentration of heavy Sn doped β-Ga2O3 crystals showed an interesting partially reversible phenomenon after ...
Yiyuan Liu, Jiahao Yao, Huihui Li, Zhitai Jia, Jiandong Ye, Xutang Tao, Wenxiang Mu   +6 more
doaj   +1 more source

Crystal structure of 4-(4-(1H-imidazol-1-yl)phenyl)-2,6-diphenylpyridine, C26H19N3

Zeitschrift für Kristallographie - New Crystal Structures, 2005
C26H19N3, monoclinic, P121/c1 (no. 14), a = 12.885(1) Å, b = 15.007(2) Å, c = 10.863(2) Å, β = 109.460(8)°, V = 1980.4 Å3, Z = 4, Rgt(F) = 0.060, wRref(F2) = 0.184, T = 293 K.
Wu Y.-Z., Wang C.-X., Yu W.-T., Yang J.-X.   +3 more
doaj   +1 more source

Oxide nanotemplates for self-assembling "solid" building blocks

, 2005
It is widely accepted that self-assembling building blocks is one of the promising ways for engineering new materials. Recent years reveal substantial progress in fabricating colloidal particles, polymer blocks and supramolecular aggregates of organic ...
Balakrishnan, Barth, Barth, Berdunov, Berdunov, Berdunov, Black, Brune, Condon, Condon, Courty, Degen, Fellows, G. Mariotto, Galloway, Gustafson, I.V. Shvets, K. Balakrishnan, Ketteler, Lin, Mannig, N. Berdunov, Nilius, Noguera, Pan, Repain, Rienks, S. Murphy, Schoiswohl, Sedona, Segall, Shaikhutdinov, Skomski, Todorova, Zutic   +34 more
core   +1 more source

Elevating Photooxidation of Methane to Formaldehyde via TiO2 Crystal Phase Engineering [PDF]

, 2021
Yuheng Jiang, Wenshi Zhao, Siyang Li, Shikun Wang, Yingying Fan, Fei Wang, Xueying Qiu, Yanfei Zhu, Yin Zhang, Chang Long, Zhiyong Tang   +10 more
openalex   +1 more source